Sebaceous carcinoma of the parotid gland: a case report and review of the literature

Marnouche, El Amin; Maghous, Abdelhak; Kadiri, Selma El; Berhili, Soufiane; Touil, Asmae; Kettani, Fouad; Majjaoui, Sanaa El; Elkacemi, Hanane; Kebdani, Tayeb; Benjaafar, Noureddine

doi:10.1186/s13256-016-0946-z

Cited by 13 publications

(5 citation statements)

References 23 publications

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“…The salivary gland sebaceous adenocarcinoma 5‐year overall survival rate is approximately 60%, lower than the 75.2% considered for SC of the skin and orbit . Treatment of the sebaceous adenocarcinomas of the salivary glands, as well as of other sites, is basically surgical . In this study, most patients were treated only with surgery or surgery in association with other therapies, such as chemotherapy or chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 84%

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Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

Soares

Morais

Carlos³

et al. 2018

Histopathology

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Section: Discussionmentioning

confidence: 84%

“…Extra‐ocular SCs are uncommon, and most cases occur in the head and neck area . However, it is exceptionally rare in salivary glands, with only 50 cases reported to date . These tumours are recognised as sebaceous adenocarcinoma when occurring in salivary glands and tend to be aggressive, with recurrences and high metastatic potential .…”

Section: Discussionmentioning

confidence: 99%

Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

Soares

Morais

Carlos³

et al. 2018

Histopathology

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“…Large tumor cells showed sebaceous differentiation, with cellular pleomorphism, high mitotic activity and necrosis. P63, EMA, MLH1, MSH2 CK5/6, CEA, S100, CD10, Vimentin, melan A, CD45 2016 Marnouche 31 1 case Malignant proliferation composed of cells organized in nests and bays, with moderate to marked cytonuclear atypia, and a mixture of well-differentiated sebocytes and atypical basaloid cells N/A N/A 2018 Soares 6 10 cases Cells with foamy cytoplasm and presence of holocrine secretion P63, AE1AE3, CK5, CK7, CK14, EMA, adipophilin, MLH1, MSH2 AR, Factor XIIIa, S100, vimentin, perforin, SMA, calponin, CEA, ER, PR, PAS 2020 Holzgreve 12 1 case N/A N/A N/A 2021 Syder 32 1 case Heterotopic salivary gland tissue embedded within the subcutaneous tissue P63, CK5/6, AR, SOX-10, P16, PAX8, BerEP4 2022 Pratt 10 1 case Nests of basaloid cells at the periphery and areas of distinct sebaceous differentiation, separated by bands of extensive hyalinization.No necrosis, lymphovascular or perineural invasion EMA, CD15, lactoferrin, GCDFP-2, AR N/A 2022 Our case 1 case The malignant cells is characterized by pleomorphic nuclei with prominent nucleoli and foamy cytoplasm. Moderate numbers of mitoses were present.…”

Section: Discussionmentioning

confidence: 99%

Sebaceous Carcinoma of the Submandibular Gland a Case Report and Review of the Literature

Wang¹,

Luo²,

Shi³

et al. 2023

CMAR

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Objective Sebaceous carcinoma (SC) of the submandibular gland is extremely rare. Owing to the low morbidity and nonspecific clinical manifestations, diagnosis is commonly delayed, which increases metastasis and mortality. To date, there have been five reported cases of SC of the submandibular gland. Here, we present a new case and review the relevant literature. Methods and Results A 36-year-old woman presented with an enlarged left submandibular gland. Clinical features included a non-tender solitary nodular mass with normal overlying skin. There were no special findings on computed tomography or ultrasound examination except for a swollen mass in the left submandibular gland. The patient underwent surgical resection. Pathological examination confirmed the diagnosis of SC with nerve infiltration. Immunohistochemical examination of this case showed positive staining for P63, P40, CK7, CK8/18, MLH1, MSH2, MSH6, and PMS2. The specimen was negative for androgen receptor, CEA, S-100, CK5/6, SOX-10, SOX-11, SMA, and GCDFP-15. The KI-67 labeling index was determined to be 15%. PAS and anti-epithelial membrane antigen were positive in partial area. The patient is still undergoing follow-up, and no metastasis or recurrence has been observed for 2 months. Conclusion This case highlighted the fact that despite its rarity, SC should be considered as a differential diagnosis for masses located in the head and face. Early and accurate diagnosis, followed by wide surgical excision, has a favorable prognosis. Therefore, clinicians should be familiar with the clinical and pathological features of this disease.

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“…The origin of extracutaneous SC in different location is not exactly the same. SC of parotid gland is originate from the pluripotential cells distributed in the blind-ending intercalated and striated ducts, which can differentiate into sebaceous that secondary to obstruction or in ammation, or congenital presence of sebaceous differentiation [14]. SC in oral cavity is thought to arise from salivary gland elements or ectopic sebaceous glands, that is fordyce's spots, which are usually found in buccal mucosa, soft palate, upper lip, or gingiva, etc [15].…”

Section: Discussionmentioning

confidence: 99%

Primary Sebaceous Carcinoma of Esophagus: The First Case Report and Literature Review

Zhou

Cheng

Zhao

et al. 2022

Preprint

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Background：Sebaceous carcinoma (SC) is an uncommon neoplasm that usually occur in the skin of head and neck region with a predilection of periocular sites. This tumor is thought to arise from sebaceous glands in the skin and thus may arise anywhere on the body where these glands exist. However, the noncutaneous SC in where the sebaceous glands are anatomically absent have also been reported sporadically, and the pre-existing ectopic sebaceous glands are speculated to be the basis of its origination. Though ectopic sebaceous glands are not uncommon in esophagus, primary SC in esophagus has not been reported thus far. Aims: To report for the first time one primary esophageal SC in a 66-year-old man, investigated its clinicopathological features, diagnostic points and differential diagnosis from other malignancy. Methods：Clinical and radiological data were collected; the tumor morphology and immunohistochemical pattern were analyzed. Related literatures were reviewed. Results：The tumor cells diffusely expressed P40, CK5/6, AR and P53, and EMA staining highlighted the sebocytes with a foam-like pattern in cytoplasm. With the auxiliary immunohistochemical staining, we finally made an unequivocal diagnosis of SC. Conclusions：SC is a rare entity in esophagus which have not been reported before and may bring up diagnostic puzzles to pathologists. The tumor morphology is complex and with a similar immunohistochemical expression profiles just like SC reported in other sites. This unique tumor occur in esophagus extends the spectrum of extraocular, extracutaneous SC from existing case reports.

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Sebaceous carcinoma of the parotid gland: a case report and review of the literature

Cited by 13 publications

References 23 publications

Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

Sebaceous Carcinoma of the Submandibular Gland a Case Report and Review of the Literature

Primary Sebaceous Carcinoma of Esophagus: The First Case Report and Literature Review

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