Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature

Izutsu, Takashi; Kumamoto, Hiroyuki; Kimizuka, Satoshi; Ooya, Kiyoshi

doi:10.1054/ijom.2002.0370

Cited by 29 publications

(8 citation statements)

References 11 publications

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“…Sebaceous lymphadenoma (SLA) of the salivary gland is a rare histologic variant of lymphadenoma with sebaceous differentiation or sebaceous adenoma with a dense lymphocytic background . SLA typically occurs in adults over 50 years of age (ranging from 13 to 89) with no predilection toward either sex .…”

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Fine‐needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland

Haar

DeFrias

Lin

2013

Diagnostic Cytopathology

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Sebaceous lymphadenoma (SLA) is a histologic variant of lymphadenoma or sebaceous adenoma of the salivary gland. The fine-needle aspiration (FNA) cytology of SLA has not been well-described. In this report, we reported a case that involved an 81-year-old male with a long-standing left parotid mass and was diagnosed on FNA cytology. The FNA smears showed clusters of three types of epithelial cells in a background of abundant lymphoid cells, macrophages and abundant proteinaceous materials. The predominant epithelial cells were large polygonal cells with abundant cytoplasm filled with multiple, uniform, small, and clear vacuoles, ill-defined cytoplasmic borders, and small centrally located round nuclei with finely granular chromatin, conspicuous nucleoli and indented nuclear membranes apparently imprinted by cytoplasmic vacuoles. These cells were surrounded by polygonal or flat cells with less or more dense cytoplasm, indistinct cell borders and round or oval small nuclei with smooth nuclear membranes, which correspond to germinative or basaloid cells. Some cells had granular cytoplasm. Large three dimensional clusters of nonkeratinized squamous cells have oval nuclei containing evenly distributed chromatin, and scant to moderate dense cytoplasm that were arranged in a "stream of fish" pattern. Rare granulomas and cystic contents (degenerated cells, inflammatory cells, macrophages, and abundant granular debris/proteinaceous material) were also seen. The diagnosis of SLA was confirmed by the surgical resection.

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confidence: 99%

Fine‐needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland

Haar

DeFrias

Lin

2013

Diagnostic Cytopathology

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“…Seventy percent are found on the head, with the most common site being the nose and cheek area, while 30% are found on the trunk, neck, and legs [3]. Occasionally, sebaceous adenomas may occur intraorally [3][4][5]. In the past, it has been suggested that there is a greater incidence in males [3]; however, recent literature indicates sebaceous adenomas affect both sexes equally [1].…”

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confidence: 99%

Revisiting Sebaceous Adenoma: Case Report and Discussion

Nishita¹,

Adams²,

Matthew³

et al. 2019

Dermatol Arch

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Sebaceous adenomas are rare adnexal tumors that are associated with Muir-Torre syndrome. Although sebaceous adenomas are considered benign entities, this is controversial. It has been suggested that sebaceous adenomas are actually low-grade sebaceous carcinomas. In this report, we defend the view that sebaceous adenomas are in fact lowgrade sebaceous carcinomas by presenting a lesion with a clinical presentation typical for sebaceous carcinoma with histopathology characteristic of sebaceous adenoma.

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“…Primary sebaceous tumors of salivary gland origin are also rare. 7 In humans, these tumors are broadly classified into 4 groups: sebaceous adenoma, sebaceous lymphadenoma, sebaceous lymphadenocarcinoma, and sebaceous carcinoma/adenocarcinoma. 9 To date, the reports of salivary gland sebaceous adenoma come from the human literature, wherein sebaceous adenomas account for 0.1% of all salivary tumors.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma ex Pleomorphic Adenoma with Sebaceous Differentiation in the Mandibular Salivary Gland of a Dog

Smrkovski¹,

LeBlanc²,

Smith³

et al. 2006

Vet Pathol

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Abstract. A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog. The animal presented with a large nonpainful swelling in the left submandibular region. A computed tomography scan detected an irregularly enhancing soft tissue mass that was closely associated with the left external ear canal and extended to the left wing of the atlas. On surgical exploration, the mass was intimately associated with the left mandibular salivary gland. Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology. The tumor was comprised of basaloid and low columnar epithelial cells, many glandular units formed by well-differentiated sebocytes, and multifocal regions of necrosis, mineralization, and hemorrhage. Salivary gland tumors with sebaceous differentiation are very rare in animals, with one previously reported case in a cat.Key words: Carcinoma; dogs; salivary gland; tumor.An 8-year-old female spayed Basset Hound was presented to the University of Tennessee Veterinary Teaching Hospital because of a mass located in the left submandibular area. The mass was first noticed by the owners 2-3 months prior to presentation and was gradually increasing in size. The dog was otherwise healthy and exhibited no clinical signs associated with the mass. At presentation, the mass was subcutaneous, fixed, and firm on palpation. Fine needle aspirate of the mass revealed many streaming erythrocytes and nucleated cells, suggesting a mucinous background. The heterogeneous cell population consisted of a few large aggregates of well-differentiated salivary secretory epithelial cells and several large clusters of uniform, basophilic cells exhibiting a high nuclear-to-cytoplasmic ratio. The aspirate was considered to be of salivary gland origin; differentials for the mass included basal cell tumor or a well-differentiated ductular tumor.A computed tomography (CT) scan showed a focal, well-circumscribed, heterogenous-density mass measuring approximately 44 (dorsoventral dimension) 3 35 (mediolateral dimension) 3 48 (rostrocaudal dimension) mm arising within the left mandibular salivary gland (Fig. 1). The mass was expansive within the gland, effacing the adjacent gland parenchyma. Postcontrast images revealed nonuniform enhancement of the mass with normal strong uniform enhancement of the adjacent compressed glandular tissue. There was mild enlargement of one of the adjacent submandibular lymph nodes. Imaging diagnosis was of a discrete mass arising within the left mandibular salivary gland with mild associated lymphadenomegaly. Primary consideration was given to a neoplastic process.Surgical excision of the mass and an enlarged left submandibular lymph node was performed. Grossly, the mass was intimately associated with the left mandibular salivary gland. The salivary gland itself, however, was compressed by the mass to the periphery and did not appear to be involved.Four sections of the mass with adjacent salivary gland and two sections of th...

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Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature

Cited by 29 publications

References 11 publications

Fine‐needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland

Fine‐needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland

Revisiting Sebaceous Adenoma: Case Report and Discussion

Carcinoma ex Pleomorphic Adenoma with Sebaceous Differentiation in the Mandibular Salivary Gland of a Dog

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