Abstract. A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog. The animal presented with a large nonpainful swelling in the left submandibular region. A computed tomography scan detected an irregularly enhancing soft tissue mass that was closely associated with the left external ear canal and extended to the left wing of the atlas. On surgical exploration, the mass was intimately associated with the left mandibular salivary gland. Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology. The tumor was comprised of basaloid and low columnar epithelial cells, many glandular units formed by well-differentiated sebocytes, and multifocal regions of necrosis, mineralization, and hemorrhage. Salivary gland tumors with sebaceous differentiation are very rare in animals, with one previously reported case in a cat.Key words: Carcinoma; dogs; salivary gland; tumor.An 8-year-old female spayed Basset Hound was presented to the University of Tennessee Veterinary Teaching Hospital because of a mass located in the left submandibular area. The mass was first noticed by the owners 2-3 months prior to presentation and was gradually increasing in size. The dog was otherwise healthy and exhibited no clinical signs associated with the mass. At presentation, the mass was subcutaneous, fixed, and firm on palpation. Fine needle aspirate of the mass revealed many streaming erythrocytes and nucleated cells, suggesting a mucinous background. The heterogeneous cell population consisted of a few large aggregates of well-differentiated salivary secretory epithelial cells and several large clusters of uniform, basophilic cells exhibiting a high nuclear-to-cytoplasmic ratio. The aspirate was considered to be of salivary gland origin; differentials for the mass included basal cell tumor or a well-differentiated ductular tumor.A computed tomography (CT) scan showed a focal, well-circumscribed, heterogenous-density mass measuring approximately 44 (dorsoventral dimension) 3 35 (mediolateral dimension) 3 48 (rostrocaudal dimension) mm arising within the left mandibular salivary gland (Fig. 1). The mass was expansive within the gland, effacing the adjacent gland parenchyma. Postcontrast images revealed nonuniform enhancement of the mass with normal strong uniform enhancement of the adjacent compressed glandular tissue. There was mild enlargement of one of the adjacent submandibular lymph nodes. Imaging diagnosis was of a discrete mass arising within the left mandibular salivary gland with mild associated lymphadenomegaly. Primary consideration was given to a neoplastic process.Surgical excision of the mass and an enlarged left submandibular lymph node was performed. Grossly, the mass was intimately associated with the left mandibular salivary gland. The salivary gland itself, however, was compressed by the mass to the periphery and did not appear to be involved.Four sections of the mass with adjacent salivary gland and two sections of th...
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