Seasonal Variations in Serum 25-Hydroxycholecalciferol in Healthy People

McLaughlin, Marilyn; Fairney, Angela; Lester, Eva P.; Raggatt, P R; Brown, David J.; Wills, M. R.

doi:10.1016/s0140-6736(74)92717-2

Cited by 169 publications

(59 citation statements)

References 8 publications

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“…The present study clearly indicates that there is a significant seasonal variation in the serum24,25-(OH)2-D levels as well as in the 25-OH-D levels. The latter has been reported by Haddad et al(1974), McLauglin et al(1974) and Stryd et al(1979).…”

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confidence: 58%

Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.

et al. 1980

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confidence: 58%

Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.

et al. 1980

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“…It may be related to eating patterns throughout the day as the dietary questionnaires revealed that some of the children ate vitamin D in the form of fortified cereals for breakfast. Although seasonal variations in serum 25-OHD concentration are well established (McLaughlin et al 1974), diurnal variations of serum 25-OHD have not been observed (Juttmann et al 1981). The differences between seasonal and diurnal rhythms of serum 25-OHD may be explained by Fraser's (1981) The variation in salivary 25-OHD observed in the children studied may be related to the circadian rhythm that is now accepted as a basic element of human physiology (Moore-Ede et al 1983).…”

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confidence: 99%

Studies on the measurement of 25-hydroxy vitamin D in human saliva

Fairney

Saphier

1987

Br J Nutr

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1. A competitive protein-binding assay for 25-hydroxy vitamin D (25-OHD) in saliva has been established by adaptation of that previously described for 25-OHD in serum (Fairney et al. 1979).2. Random values of salivary 25-OHD in patients attending hospital for venesection showed a wide range of results (105-1000 pg/ml, n 55). These values corresponded to 1.2% of the total serum values with which they showed a significant relation (r 0.45, P < 0.001).3. There was no relation between salivary 25-OHD and measured serum free 25-OHD in eighteen pairs of saliva and serum studied. METHODS Collection of samplesUnstimulated samples of whole saliva (approximately 2 ml) were collected directly into glass bottles from normal volunteer subjects or patients attending for phlebotomy. Serum was collected simultaneously and all samples were stored in glass bottles at -20" until thawed before assay. Permission to collect these samples was obtained from the Local Ethical Commit tee.The saliva samples contained varying amounts of particulate matter to which 25-OHD3 bound on storage. To obtain a homogenous mixture for assay, the thawed samples were sonicated at amplitude 6 for 30 s before use, using a MSE Soniprep 150 (MSE Scientific Instruments, Crawley, Sussex).

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“…In countries around the equator, UV light and, therefore, the production of vitamin D, is constant throughout the year (Glerup et al, 2000). However, seasonal variation in UV intensity, as occurs both far North and South of the equator, results in marked variation in vitamin D status throughout the year, with highest concentrations found in late summer and markedly lower concentrations observed in late winter (McLaughlin et al, 1974;McKenna, 1992). This seasonal pattern is apparent in all European countries, but is particularly evident in northern European countries, including the UK and Ireland, which are located at 50-601N (Ovesen et al, 2003;Zittermann, 2003).…”

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confidence: 99%

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

et al. 2006

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Objective: To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover. Design: Double-blinded randomised controlled intervention study. Setting: University of Ulster, Coleraine, Northern Ireland. Subjects: In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18-27 years, were recruited from the university, with 27 completing the intervention. Interventions: Subjects were randomly assigned, to receive either 15 mg (600 IU) vitamin D 3 and 1500 mg calcium/day (vitamin D group), or 1500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention.

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Seasonal Variations in Serum 25-Hydroxycholecalciferol in Healthy People

Cited by 169 publications

References 8 publications

Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.

Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.

Studies on the measurement of 25-hydroxy vitamin D in human saliva

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

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