Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.

Kano, Kenichi; Yoshida, Hisashi; Yata, Junichi; Suda, Toshio

doi:10.1507/endocrj1954.27.215

Cited by 20 publications

(7 citation statements)

References 7 publications

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“…Presented in Figure 4 are the means by months, which revealed a significant rise in the summer ( p < 0.001). A direct correlation existed between 25(OH)D3 and 24,25(OH),D3 ( r = 0.773; p < 0.001), which has been reported by others (6,14,28,29).…”

Section: Resultssupporting

confidence: 79%

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Vitamin D Metabolite Levels in Normal Children

Taylor

Norman

1984

Pediatr Res

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SummaryVitamin D metabolite levels were measured in 174 normal children throughout the year. 25-hydroxyvitamin D3 (25(OH)D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) levels showed a seasonal variation; both levels were higher in summer than in winter ( p < 0.001 for both). There was a fall in the 1,25-dihydroxyvitamin D (1,25(OH)2D) level in August and September ( p < 0.001), which coincided with a rise in mean 25(OH)D3 and 24,25(OH)2D3 levels. An inverse correlation was seen between 1,25(OH)2D and 24,25(OH),D3 levels ( r = -0.233; p < 0.01). 25(OH)D3 levels increased with age only for winter values (<3 years, 11.70 f 3.98 ng/ml; 3-1 1 years, 18.38 f 1.65 ng/ml; >I1 years, 23.60 f 4.60 ng/ml) while 1,25(OH),D and 24,25(OH)& levels did not show an age-related difference. Intake of multivitamins had an interesting effect on 25(OH)D, and 24,25(OH)2D3 levels in the winter but not in the summer; the endogenous metabolite levels were lower in the vitamin supplemented children [25(OH)D3: 23.05 f 7.35 versus 15.77 f 5.51 ng/ml, p < 0.001; 24,25(OH)2D3: 2.30 .+ 1.11 versus 1.66 f 0.88 ng/ml, p < 0.051. Children studied in the winter who were not receiving supplemental vitamins were older than those who did receive the vitamins (7.26 f 2.64 versus 5.42 f 3.17 years; p < 0.01). Sixteen of the children had both winter and summer measurements. Their 25(OH)D3 and 24,25(OH)2D3 levels showed the same seasonal variation as the overall group data, while their 1,25(OH)2D levels showed no consistent pattern. Our data suggest that establishing normal pediatric values for 25(OH)D3, 1,25(OH)2D, and 24,25(OH),D3 requires consideration of season, age, and supplemental vitamin D intake, and that such information be available to investigators in order to make meaningful interpretations of vitamin D metabolite levels in disease states. Major advances in our understanding of vitamin D metabolism over the past 15 years (7, 18) have led to increased interest in the study of vitamin D metabolite levels in a variety of disease states, with or without concomitant vitamin D therapy (3, 10, 1 1, 19, 20, 2 1, 23, 25, 28). As with any new laboratory assay, normal values first had to be established, with consideration given to the influence of age and sex on these values. With regard to the major vitamin D metabolites, 25(OH)D3, 1,25(OH)?D,

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Section: Resultssupporting

confidence: 79%

“…Finally, none of the previous studies have measured all three major vitamin D metabolites in the same group of children in both summer and winter. We were interested to learn if seasonal variation [e.g., for 25(OH)D3 and possibly for 24,25(OH)?D3] previously reported for group data (2,5,13,14,22,29) was also present in individual patients.…”

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confidence: 99%

Vitamin D Metabolite Levels in Normal Children

Taylor

Norman

1984

Pediatr Res

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“…The 1,25‐dihydroxyvitamin D was slightly elevated (86.0 ± 61.5 pg/mL). In five out of seven tested patients, the levels of 25‐hydroxyvitamin D were decreased and, especially, two patients (patients 6 and 7) had very low levels even though patients’ age and season at diagnosis were considered 7 . Patient 5 had a slightly low level of 25‐hydroxyvitamin D for the season at diagnosis (September) 7 .…”

Section: Resultsmentioning

confidence: 94%

“…In five out of seven tested patients, the levels of 25‐hydroxyvitamin D were decreased and, especially, two patients (patients 6 and 7) had very low levels even though patients’ age and season at diagnosis were considered 7 . Patient 5 had a slightly low level of 25‐hydroxyvitamin D for the season at diagnosis (September) 7 . Although the 25‐hydroxyvitamin D level in patient 8 was within the normal range, elevated level of parathyroid hormone suggested the latent deficiency of vitamin D. Maternal vitamin D levels were not evaluated.…”

Section: Resultsmentioning

confidence: 95%

Vitamin D deficiency rickets caused by improper lifestyle in Japanese children

Miyako

Kinjo

Kohno

2005

Pediatrics International

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“…The patient's serum 25-OH-D concentration was decreased, as often seen in the elderly [14]. Since the sample was taken in June, when serum 25-OH-D tends to be high [15], the patient probably had a mild vitamin D deficiency. However, the serum 1,25-(OH)2-D level in the present case was extremely increased to 226 pg/ml, the highest value among 40 patients with primary hyperparathyroidism in whom the vitamin D metabolites were analyzed in our clinic.…”

Section: Case Reportmentioning

confidence: 88%

A Patient with Primary Hyperparathyroidism Associated with Osteomalacia: Markedly Increased Serum Levels of Intact PTH and 1,25-Dihydroxyvitamin D with Normo- and Hypercalcemia.

et al. 1993

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Abstract. A 65-year-old female patient was admitted with complaining chiefly of lower back pains and arthralgia in the bilateral knee joints of 10-years duration. The serum calcium concentration was normal or only slightly increased, whereas the serum intact PTH and 1,25-dihydroxyvitamin D concentrations were substantially increased. Serum phosphate and 25-hydroxyvitamin D concentrations were decreased. Renal function was normal. Serum alkaline phosphatase activity, the osteocalcin concentration and urinary hydroxyproline excretion were markedly increased. Bone X-ray examination showed severe osteopenia and bone biopsy revealed hyperosteoidosis without tetracycline deposition, consistent with osteomalacia. A parathyroid adenoma was demonstrated by echography and CT-scan. Surgical exploration of the neck revealed a chief cell adenoma behind the right upper pole of the thyroid gland. After parathyroidectomy, all the abnormal biochemical data gradually normalized and the patient has been doing well without any symptoms for the last 13 months. These clinical data suggest that osteomalacia of the patient was probably induced by hypophosphatemia of prolonged duration. When hypercalcemia is not evident in a patient with primary hyperparathyroidism, in whom serum alkaline phosphatase and intact PTH levels are inappropriately increased, osteomalacia should be taken into consideration. [2,3]. In a few reported cases, the serum calcium values were even subnormal (8 mg/dl), apparently due to hypoproteinemia caused by the associated gluten enteropathy [3,4]. We report a case of primary hyperparathyroidism with osteomalacia, in whom hypercalcemia was very mild, despite markedly increased serum concentrations of intact PTH and 1,25-(OH)2-D.

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Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans.

Abstract: Abstract

Cited by 20 publications

References 7 publications

Vitamin D Metabolite Levels in Normal Children

Vitamin D Metabolite Levels in Normal Children

Vitamin D deficiency rickets caused by improper lifestyle in Japanese children

A Patient with Primary Hyperparathyroidism Associated with Osteomalacia: Markedly Increased Serum Levels of Intact PTH and 1,25-Dihydroxyvitamin D with Normo- and Hypercalcemia.

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