Seasonal variation of serum 25(OH) vitamin D levels in maternal and umbilical cord blood in Japanese women

Sogawa, Eishi; Kaji, Tatsuru; Nakayama, Sosogu; Yoshida, Atsuko; Yonetani, Naoto; Maeda, Keisuke; Irahara, Minoru

doi:10.2152/jmi.66.128

Cited by 8 publications

(16 citation statements)

References 28 publications

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“…The assessment criteria for vitamin D deficiency/insufficiency proposed by the expert panel was as follows: 25(OH)D equal to or above 30 ng/mL was considered to be vitamin D sufficient; 25(OH)D less than 30 ng/mL but not less than 20 ng/mL was considered to be vitamin D insufficient; 25(OH)D less than 20 ng/mL was considered to be vitamin D deficient. Low maternal 25(OH)D has been reported among Japanese pregnant women [17][18][19][20][21][22][23], even though the assessment criteria for vitamin D deficiency/insufficiency among pregnant women has not been defined yet. The proposed assessment criteria have mentioned that different criteria may be needed for pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Takaoka¹,

Nishida²,

Sairenchi³

et al. 2020

PLoS ONE

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Objectives There have been no longitudinal surveys on the changes in 25-hydroxyvitamin D [25(OH)D] while considering hemodilution factors among pregnant Japanese women. Therefore, we examined 25(OH)D levels as well as red blood cell count (RBC), hemoglobin (Hb), and Hematocrit (Hct) at the three trimesters among pregnant Japanese women to determine the distribution of serum 25(OH)D levels and the influence of hemodilution.

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Section: Introductionmentioning

confidence: 99%

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Takaoka¹,

Nishida²,

Sairenchi³

et al. 2020

PLoS ONE

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“…27,28 The most similar results were reported recently by Wierzejska et al, 26 who reported cord values 40% higher than maternal values. However, reverse significant correlations (i.e., lower cord blood values than maternal values) have also been reported, 5,9,11,30 as well as maternal 25(OH)D levels equal to cord levels. 29 We further evaluated the potential effect of cord blood 25(OH)D deficiency on neonatal outcomes.…”

Section: Discussionmentioning

confidence: 97%

“…Vitamin D cord blood status is directly dependent on maternal levels of 25(OH)D. 9 – 12 Several maternal risk factors contribute to low maternal–fetal 25(OH)D concentrations. 13 Vitamin D insufficiency in the mother results in neonatal insufficiency, which may negatively affect the anthropometric parameters in the neonate, skeletal health, the immune system, and neurological development, and might increase the risk of asthma and type 1 diabetes in later life.…”

Section: Introductionmentioning

confidence: 99%

Association between umbilical cord vitamin D levels and adverse neonatal outcomes

et al. 2020

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Objective We investigated the associations between cord blood concentration of 25-hydroxyvitamin D [25(OH)D], neonatal outcomes, and the risk of hospitalization during the first year of life. Methods A total of 402 newborn infants and their mothers were prospectively enrolled and divided in four groups according to season of the year. We determined 25(OH)D serum concentrations from maternal–neonatal pairs at delivery by electrochemiluminescence immunoassay. Cut-offs at 25, 50, and 75 nmol/L defined vitamin D status, corresponding to deficiency, insufficiency, and sufficiency, respectively. Crude odds ratio (cOR) and 95% confidence intervals (CI) were estimated using logistic regression. Results Vitamin D severe deficiency (i.e., <25 nmol/L) was present in 18% of newborns. Cord blood severe deficiency was associated with an increased risk of preterm birth (cOR 3.6, 95% CI: 1.1–12.2), neonatal respiratory distress syndrome (cOR 5.9, 95% CI: 1.1–33.2), and increased risk of hospitalization during the first year of life because of acute respiratory infection (cOR 3.9, 95% CI: 1.4–10.6) or acute gastroenterocolitis (cOR 5.2, 95% CI: 1.4–19.1). Conclusion Cord blood vitamin D deficiency is associated with increased risk of preterm birth, neonatal respiratory distress syndrome, and hospitalization during the first year of life.

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“…Though the measurement of vitamin D is predominantly performed on blood samples obtained by venipuncture in clinical practice (for diagnostic/therapeutic purposes), for research purposes, vitamin D is measured in other biological matrices, such as urine [ 41 ], tissues [ 52 , 53 ], tissue culture cells, umbilical cord blood [ 54 , 55 , 56 ], finger-prick blood [ 57 ], amniotic fluid [ 58 , 59 ], breastmilk [ 38 ], and synovial fluid [ 19 ]. Table 1 lists vitamin D metabolites that have been detected in different biological matrices in a wide concentration range from a few picograms to dozens of nanograms per milliliter of liquid sample.…”

Section: Vitamin D Determinationmentioning

confidence: 99%

Vitamin D: Current Challenges between the Laboratory and Clinical Practice

Máčová

Bičı́ková

2021

Nutrients

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Vitamin D is a micronutrient with pleiotropic effects in humans. Due to sedentary lifestyles and increasing time spent indoors, a growing body of research is revealing that vitamin D deficiency is a global problem. Despite the routine measurement of vitamin D in clinical laboratories and many years of efforts, methods of vitamin D analysis have yet to be standardized and are burdened with significant difficulties. This review summarizes several key analytical and clinical challenges that accompany the current methods for measuring vitamin D. According to an external quality assessment, methods and laboratories still produce a high degree of variability. Structurally similar metabolites are a source of significant interference. Furthermore, there is still no consensus on the normal values of vitamin D in a healthy population. These and other problems discussed herein can be a source of inconsistency in the results of research studies.

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Seasonal variation of serum 25(OH) vitamin D levels in maternal and umbilical cord blood in Japanese women

Cited by 8 publications

References 28 publications

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Association between umbilical cord vitamin D levels and adverse neonatal outcomes

Vitamin D: Current Challenges between the Laboratory and Clinical Practice

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