Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Takaoka, Nobuko; Nishida, Keiko; Sairenchi, Toshimi; Umesawa, Mitsumasa; Noguchi, Rie; Someya, Katsumi; Kobashi, Gén

doi:10.1371/journal.pone.0239954

Cited by 13 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some previous studies have reported that pregnant women with VD deficiency had a significantly higher risk of anemia, but in their studies, only one or two measurements of 25(OH)D were conducted [22][23][24][25][26]. However, in our study, we measured 25(OH)D at three trimesters, respectively; meanwhile, we also found that 25(OH)D in T1, T2, and T3 were positively correlated with Hb, respectively.…”

Section: Discussioncontrasting

confidence: 56%

Association of Vitamin D in Different Trimester with Hemoglobin during Pregnancy

Peng

Cheng

et al. 2022

Nutrients

View full text Add to dashboard Cite

The association between vitamin D and hemoglobin has been suggested. Vitamin D can affect erythropoiesis by the induction of erythroid progenitor cell proliferation and enhance iron absorption by regulating the iron-hepcidin-ferroportin axis in monocytes. However, this relationship in pregnant women is scarce. The purpose of this study was to investigate the association between plasma vitamin D levels with hemoglobin concentration in pregnant women considering each trimester and iron supplementation. The data were obtained from Zhoushan Pregnant Women Cohort, collected from 2011 to 2018. Plasma 25(OH)D was measured in each trimester using liquid chromatography–tandem mass spectrometry. Generalized estimating equations and multiple linear regressions were performed. Finally, 2962 pregnant women and 4419 observations in the first trimester were included in this study. Plasma 25(OH)D in first trimester (T1) (β = 0.06, p = 0.0177), second trimester (T2) (β = 0.15, p < 0.0001), and third trimester (T3) (β = 0.12, p = 0.0006) were positively associated with Hb. Association between plasma 25(OH)D levels in T1 and Hb concentration was positively associated with gestational age (β = 0.005, p = 0.0421). Pregnant women with VD deficiency in T1 (OR = 1.42, 95% CI: 1.07–1.88) or T2 (OR = 1.94, 95% CI: 1.30–2.89) presented an increased risk of anemia, compared with women without VD deficiency. Moreover, the significant relationship between VD and Hb was only observed among women with iron supplementation during pregnancy. Plasma 25(OH)D levels in each trimester were positively associated with Hb concentration. Iron supplementation might be an important factor affecting the relationship between VD and Hb.

show abstract

Section: Discussioncontrasting

confidence: 56%

Association of Vitamin D in Different Trimester with Hemoglobin during Pregnancy

Peng

Cheng

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…This hemodilution contributes to a drop in hemoglobin levels, red blood cell count, and hematocrit (packed cell volume) levels throughout pregnancy. Other nutritional biomarkers are affected; however, hemoglobin levels, red cell count, and hematocrit levels are the main markers of hemodilution in pregnancy [ 8 , 9 ]. Our patient had similar drops in platelet count during her four consecutive pregnancies.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Gestational Thrombocytopenia Affecting Four Consecutive Pregnancies: A Case Report

Omoloye¹,

Yu²,

Sagi³

et al. 2023

Cureus

View full text Add to dashboard Cite

Gestational thrombocytopenia is the commonest cause of thrombocytopenia in pregnancy, accounting for 70-80% of cases. It is a benign condition that recovers completely in the postpartum period. Although the cause is not fully understood, it is thought that pregnancy-related hemodilution and increased platelet consumption play a significant contributory role. Several life-threatening causes of thrombocytopenia in pregnancy make up the remaining 20-30% of cases. There are reports of recurrence of GT in women, but not many case reports document more than three consecutive episodes. We present a case of a young woman who had gestational thrombocytopenia during the third trimester of her four consecutive pregnancies, followed by complete recovery after each pregnancy. We ruled out other sinister and life-threatening causes of thrombocytopenia in pregnancy. During her four consecutive pregnancies, her platelet count fell below normal at the beginning of the third trimester, with a nadir towards the end. The other hematological indices, generally used as markers of hemodilution, remained in the normal pregnancy-specific reference range during each of her four pregnancies. This case argues against pregnancy-related hemodilution being a major factor in gestational thrombocytopenia. A systematic approach is paramount when differentiating the several causes of thrombocytopenia in pregnancy.

show abstract

“…This study confirmed the results of two studies conducted in Japan which suggested that the prevalence of vitamin D deficiency was high. [10][11][12][13][14][15][16][17] To the best of our knowledge, this study is the first large sample size study which investigated vitamin D levels during pregnancy throughout 1 year in Japan, specifically looking into the effectiveness of the antenatal health guidance intervention for vitamin D insufficiency level to the pregnant women.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Vitamin D deficiency in pregnant women is a global problem, and a Japanese survey also reported that the proportion of vitamin D deficiency is high in Japanese pregnant females. [10][11][12][13][14][15][16][17] Some countries recommend the use of vitamin D supplements, 18,19 but it is not recommended in Japan, and no guidelines for the screening and supplementation of vitamin D during pregnancy are there. Moreover, sufficient evidences indicating the benefits and harms of using vitamin D supplementation during pregnancy for improving maternal and infant health outcomes are limited.…”

Section: Introductionmentioning

confidence: 99%

“…Maternal vitamin D deficiency has been linked with multiple adverse maternal and neonatal outcomes, such as hypertensive disorder of pregnancy, 3,4 gestational diabetes, 5,6 preterm birth, 7 and small gestational age of the infants 8,9 . Vitamin D deficiency in pregnant women is a global problem, and a Japanese survey also reported that the proportion of vitamin D deficiency is high in Japanese pregnant females 10–17 . Some countries recommend the use of vitamin D supplements, 18,19 but it is not recommended in Japan, and no guidelines for the screening and supplementation of vitamin D during pregnancy are there.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ineffectiveness of antenatal guidance intervention for vitamin D insufficiency and deficiency in pregnant women in Kyoto, Japan

Yamade¹,

Inoue²,

Hamada³

et al. 2021

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim: The aim of this study was to investigate the vitamin D status among healthy pregnant women in Japan, and to evaluate the effectiveness of the antenatal health guidance intervention for the pregnant women who were informed about their low vitamin D levels. Methods: We measured the level of 25-hydroxyvitamin D (25[OH]D) using chemiluminescent immunoassay among the singleton pregnant women who received at antenatal routine check-up (8-24 weeks of gestation) with written consent during September 2017-September 2018. The measurement values were informed by the concerned physician and health guidance intervention was given to the pregnant women with inadequate Vitamin D status (25[OH]D < 30 ng/mL). At around 36 weeks of gestation, the measurement of 25(OH)D and a questionnaire regarding behavioral changes after the guidance was conducted. Results: The average value of 25(OH)D of 1192 pregnant women before the guidance was 14.89 AE 4.85 ng/mL, and the prevalence of sufficient vitamin D status (25(OH)D ≥ 30 ng/mL) was 0.67% (8/1192). Nine hundred eighty-two pregnant women who had inadequate vitamin D status were followed, thereafter-guidance prevalence of sufficiency was 1.02% (10/982); insufficiency, 14.66% (144/982); and deficiency, 84.32% (828/982), respectively. Although the prevalence of deficiency was decreased after guidance intervention significantly, the prevalence was still high and the effect on behavioral changes was a little. Conclusion:The prevalence of vitamin D sufficient status among pregnant women in Japan was extremely low, which is a serious condition. It was also revealed the effectiveness of the antenatal health guidance intervention for pregnant women was not enough.

show abstract

Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey

Cited by 13 publications

References 29 publications

Association of Vitamin D in Different Trimester with Hemoglobin during Pregnancy

Association of Vitamin D in Different Trimester with Hemoglobin during Pregnancy

Recurrent Gestational Thrombocytopenia Affecting Four Consecutive Pregnancies: A Case Report

Ineffectiveness of antenatal guidance intervention for vitamin D insufficiency and deficiency in pregnant women in Kyoto, Japan

Contact Info

Product

Resources

About