Seasonal variation in specific IgE antibodies of grass-pollen hypersensitive patients depends on the steady state IgE concentration and is not related to clinical symptoms

Seasonal Increase in Human IgE and lgG4 Antisaliva Antibodies to Aedes Mosquito Bites

“…These range from immediate wheal-and-flare reactions to delayed bite papules, and it seems that most people exposed to mos quito bites start to react early in childhood [1], When mos quitoes feed, they inject saliva into the skin, and experimen tal evidence in rabbits and man suggests that bite reactions are due to specific sensitization to mosquito saliva [2][3][4], Recent immunoblot studies have demonstrated a frequent occurrence of IgE and IgG4 antibodies to Aedes communis saliva proteins in Finnish children and adults [1,5], Similar results have been obtained in Canada when examining IgE and IgG antibodies to Aedes vexans salivary glands [6,7], Aedes mosquitoes can appear in huge numbers in Scandina vian countries and North America and the bite reactions tend to be more severe at the onset of the mosquito season [4,7], However, it is not known whether mosquito antibod ies show a seasonal fluctuation similar to that reported e.g. in pollen allergy [8,9], In the present study we collected pre-and postseason se rum samples from people living in Lapland and examined the occurrence of IgE and IgG subclass antibodies to the main saliva antigens of A. communis.…”

“…The comparison of the pre-and postseason sera by densitometric analysis disclosed significant increases in the intensities o f the IgE, IgG4 and IgGl antibody bands to the main antigens in A. communis saliva. This obviously indi cates that a seasonal exposure to Aedes mosquito bites caus es an increase in the IgE and IgG4 antibody production sim ilar to that observed during the pollen season in patients with allergic rhinitis or asthma [8,9], Unfortunately, no fol low-up samples were available from our subjects in the win-ter after the mosquito season. It can be expected, however, that as in pollen allergy [8,9] the antisaliva antibody levels would decrease during the winter months and then increase again in the following mosquito season.…”

Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients

“…Some investigators found a positive association between sIgE levels and clinical symptoms [29,30], although symptoms were also dependent on other factors, such as the ease of histamine release by basophils. Other studies did not find strong associations or reported inconsistent findings [31,32]. This inconsistency may be explained by differences in allergens, age or other characteristics of the patient populations studied.…”

Can serum white birch (Betula verrucosa) pollen antigen (Bet v 1) immunoglobulin E measurement distinguish between sensitization and allergy?

“…Therefore, the airborne pollen presence could influence allergen-specific IgE production, as was reported for both pollens and mites. [27][28][29][30][31] On the other hand, a main limitation of this study is that it was cross-sectional. This aspect opens interesting future lines of research, including speculation about what will happen with sensitized patients in the future: will some transform into allergic?…”