Can serum white birch (<i>Betula verrucosa</i>) pollen antigen (Bet v 1) immunoglobulin E measurement distinguish between sensitization and allergy?

Ciprandi, Giorgio; Comite, Paola; Ferrero, Francesca; Minale, Paola; Voltolini, Susanna; Bignardi, Donatella; Fontana, Vincenzo; Bruzzone, Marco; Troise, C; Mussap, Michele

doi:10.1002/alr.21612

Cited by 6 publications

(8 citation statements)

References 27 publications

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“…Possible explanations may consist in a particular botanic milieu where Betulaceae predominates. This is in agreement with the high prevalence of birch allergy with a Bet v 1 polarized pattern (18). This Bet v 1 preponderance influences the low prevalence of oral allergy syndrome in this region (19).…”

Section: Discussionsupporting

confidence: 87%

Phleum pratense molecular pattern across Italy

Ciprandi

Scala²,

Ariano³

2017

Eur Ann Allergy Clin Immunol

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Section: Discussionsupporting

confidence: 87%

Phleum pratense molecular pattern across Italy

Ciprandi

Scala²,

Ariano³

2017

Eur Ann Allergy Clin Immunol

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“…As all Bet v 6 sensitizations remain clinically silent, this finding contradicts recently published data that the level of specific IgE is the most important predictor for allergic symptoms [13]. As incidental finding, our data confirm the recent study reporting that patients with clinical relevant sensitization show higher specific IgE levels for the major allergen Bet v 1 than patients with silent sensitization [14]. …”

Section: Discussionsupporting

confidence: 65%

The Clinical Impact of Bet v 6 in Birch Pollen-Sensitized Patients

Gellrich

Eder²,

Nicoló³

et al. 2017

Int Arch Allergy Immunol

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Background: Bet v 6, a minor birch pollen allergen, is commercially available for allergen-specific IgE antibody testing. However, there is hardly any literature on the clinical impact of Bet v 6. The aim of the present study was to analyze if testing specific IgE against Bet v 6 can add valuable benefit to the standard diagnostics of birch pollen-sensitized patients, especially in patients with unknown sensitization-eliciting allergens. Methods: Birch pollen-sensitized patients with missing IgE reactivity against Bet v 1, 2, and 4 were tested for specific IgE antibodies against Bet v 6. For comparison, an equal number of randomly selected patients with birch pollen sensitization, regardless of their individual sensitization patterns, were tested for specific anti-Bet v 6. Results: Of 57 cases with missing reactivity against the standard birch pollen allergens, 2 patients were positive for Bet v 6. In the representative sample, 3 patients showed specific IgE against Bet v 6 - resulting in a total prevalence of 5%. None of the Bet v 6-positive patients showed allergic symptoms after exposure to birch pollen or an oral allergy syndrome. An increased prevalence of asthma and a higher degree of sensitization were the only distinctive clinical features in Bet v 6-positive patients. Conclusions: Among birch pollen-sensitized patients, the prevalence of specific IgE against Bet v 6 is low. Further, sensitization to Bet v 6, which shows characteristics of a panallergen, remains clinically silent. Therefore, determination of anti-Bet v 6 is not considered useful in the clinical routine.

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“…Furthermore, all patients underwent NPT to distinguish between sensitization and allergy, even if the clinical history was suggestive of either the presence or the absence of allergic symptoms under exposure to HDM. Many other studies have the limitation that the clinical relevance of sensitization is not always proven by provocation tests, but only partially assumed based on data from the clinical history [10,15,23]. Rhinitis can by caused by many different factors.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, health professionals try to reduce the need for challenge tests in food allergy. In recent years, the question of whether in vivo challenges might be replaced by less risky in vitro tests is increasingly debated with regard to airborne allergens [10].…”

Section: Introductionmentioning

confidence: 99%

“…An increasing number of publications address the question of whether sIgE measurements might help to distinguish between clinically silent sensitization and symptomatic allergy. Whereas earlier studies primarily used allergen extracts [13,14], recent studies are mainly performed with recombinant allergen components [10,15]. Two recent publications even indicated that measurement of specific IgE to Der p 1 might consign HDM challenge tests to history [15,16].…”

Section: Introductionmentioning

confidence: 99%

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