Seasonal Variation in Sin Nombre Virus Infections in Deer Mice: Preliminary Results

Dearing, M. Denise; Previtali, M. Andrea; Jones, Jeremy D.; Ely, Patrick W.; Wood, Britta A.

doi:10.7589/0090-3558-45.2.430

Cited by 14 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, climate change may have the greatest impact on pathogens with seasonal fluctuations because the correlation of season and infection patterns suggests that short‐term (monthly) changes in weather influence pathogen dynamics. That many hantaviruses seem to have a seasonal cycle, with prevalence often being greater in the spring than in the fall, makes it a good candidate for susceptibility to climate change 50–52 …”

Section: Effects Of Climatementioning

confidence: 99%

Ecology of hantavirus in a changing world

Dearing¹,

Dizney²

2010

Annals of the New York Academy of Sciences

Self Cite

View full text Add to dashboard Cite

Hantavirus is a genus of virus represented by 45 different species and is hosted by small mammals, predominantly rats and mice. Roughly, half of all hantaviruses cause diseases in humans that vary in morbidity from mild to severe. The natural and anthropogenic changes occurring in the environment appear to be impacting the ecology of hantaviruses and their natural hosts as well as the incidence of hantaviral diseases in humans. Although such studies are limited at this time, there is evidence that natural climate cycles such as El Niño as well as anthropogenic climate change enhance hantavirus prevalence when host population dynamics are driven by food availability. Climate appears to have less of an effect on hantavirus when host populations are controlled by predators. Human alteration to the landscape also appears to enhance hantavirus prevalence when the disturbance regime enriches the environment for the host, for example, agriculture. More long-term studies on multiple species of hantavirus are needed to accurately predict the outcome of changing environmental conditions on prevalence in hosts as well as disease incidence in humans.

show abstract

Section: Effects Of Climatementioning

confidence: 99%

Ecology of hantavirus in a changing world

Dearing¹,

Dizney²

2010

Annals of the New York Academy of Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…One way to explore and quantify these effects is through manipulative field experiments using a well studied host-pathogen system. The deermouse-SNV host-pathogen system has been a subject of intensive longitudinal studies that have improved understanding of the relationships between SNV transmission dynamics with seasonal factors and with host population density [10], [31], [32], [33]. Nevertheless, longitudinal studies can be difficult to interpret because of a multitude of confounding factors that characterize uncontrolled, open populations.…”

Section: Introductionmentioning

confidence: 99%

Population Density and Seasonality Effects on Sin Nombre Virus Transmission in North American Deermice (Peromyscus maniculatus) in Outdoor Enclosures

et al. 2012

View full text Add to dashboard Cite

Surveys of wildlife host-pathogen systems often document clear seasonal variation in transmission; conclusions concerning the relationship between host population density and transmission vary. In the field, effects of seasonality and population density on natural disease cycles are challenging to measure independently, but laboratory experiments may poorly reflect what happens in nature. Outdoor manipulative experiments are an alternative that controls for some variables in a relatively natural environment. Using outdoor enclosures, we tested effects of North American deermouse ( Peromyscus maniculatus ) population density and season on transmission dynamics of Sin Nombre hantavirus. In early summer, mid-summer, late summer, and fall 2007–2008, predetermined numbers of infected and uninfected adult wild deermice were released into enclosures and trapped weekly or bi-weekly. We documented 18 transmission events and observed significant seasonal effects on transmission, wounding frequency, and host breeding condition. Apparent differences in transmission incidence or wounding frequency between high- and low-density treatments were not statistically significant. However, high host density was associated with a lower proportion of males with scrotal testes. Seasonality may have a stronger influence on disease transmission dynamics than host population density, and density effects cannot be considered independent of seasonality.

show abstract

“…The presence of MatAbs among young individuals has been acknowledged in several hantavirus studies (e.g. Mills et al 1997Mills et al , 1999Borucki et al 2000;Escutenaire et al 2000;Calisher et al 2007;Dearing et al 2009). However, their role in infection dynamics has largely been neglected in studies on hantaviruses and on natural populations generally, despite recent acknowledgement of the potential of MatAbs to influence disease dynamics in wildlife populations through altering the amount of susceptible individuals (Gasparini et al 2001;Staszewski et al 2007;Bouliner & Staszewski 2008), and their recent inclusion in theoretical studies (Fouchet et al 2006(Fouchet et al , 2007(Fouchet et al , 2008.…”

Section: Introductionmentioning

confidence: 99%

Hantavirus infections in fluctuating host populations: the role of maternal antibodies

Kallio

Begon

Henttonen³

et al. 2010

Proc. R. Soc. B.

View full text Add to dashboard Cite

Infected females may transfer maternal antibodies (MatAbs) to their offspring, which may then be transiently protected against infections the mother has encountered. However, the role of maternal protection in infectious disease dynamics in wildlife has largely been neglected. Here, we investigate the effects of Puumala hantavirus (PUUV)-specific MatAbs on PUUV dynamics, using 7 years' data from a cyclic bank vole population in Finland. For the first time to our knowledge, we partition seropositivity data from a natural population into separate dynamic patterns for MatAbs and infection. The likelihood of young of the year carrying PUUV-specific MatAbs during the breeding season correlated positively with infection prevalence in the overwintered parent population in the preceding spring. The probability of PUUV infection varied between seasons (highest in spring, lowest in late summer) and depended on population structure, but was also, in late autumn, notably, negatively related to summer MatAb prevalence, as well as to infection prevalence earlier in the breeding season. Hence, our results suggest that high infection prevalence in the early breeding season leads to a high proportion of transiently immune young individuals, which causes delays in transmission. This suggests, in turn, that MatAb protection has the potential to affect infection dynamics in natural populations.

show abstract

Seasonal Variation in Sin Nombre Virus Infections in Deer Mice: Preliminary Results

Cited by 14 publications

References 27 publications

Ecology of hantavirus in a changing world

Ecology of hantavirus in a changing world

Population Density and Seasonality Effects on Sin Nombre Virus Transmission in North American Deermice (Peromyscus maniculatus) in Outdoor Enclosures

Hantavirus infections in fluctuating host populations: the role of maternal antibodies

Contact Info

Product

Resources

About