Seasonal variation in cardiovascular disease risk factors in a subarctic population: the Tromsø Study 1979–2008

Hopstock, Laila Arnesdatter; Barnett, Adrian; Bønaa, Kaare Harald; Mannsverk, Jan; Njølstad, Inger; Wilsgaard, Tom

doi:10.1136/jech-2012-201547

Cited by 44 publications

(44 citation statements)

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“…Seasonal variation has been reported in various diseases and conditions. Winter is associated with an increased risk of cardiovascular events, morbidity, and mortality due to the environmental temperature (8,9). Exposure to lower temperatures has been linked to induction of cardiac electrical instability, ventricular arrhythmias, myocardial infarction, acute ischemia, peripheral vasoconstriction, sudden cardiac death, and deep venous thrombosis (8,9).…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac glucose metabolism depends on numerous factors including substrate availability, cardiac workload, myocardial perfusion, and medication (7). Increased sympathetic activity drives increased metabolic demand for glucose (8,9), and although the connection has yet to be reported in the literature, this investigation hypothesized that the increased sympathetic activity associated with cooler ambient temperatures results in comparatively increased cardiac 18 F-FDG uptake over a warmer ambient temperature. …”

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confidence: 91%

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Ambient Temperature and Cardiac Accumulation of 18F-FDG

O’Loughlin

Currie

Trifonovic

et al. 2014

Journal of Nuclear Medicine Technology

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Warming patients by changing the ambient environment (rather than core temperature) has been reported to reduce brown adipose tissue activity, thereby reducing artifacts in 18 F-FDG PET. Nonetheless, a reduction in cardiac uptake of 18 F-FDG has been incidentally noted during ambient warming. This study examined the impact of seasonal variations in ambient temperatures on cardiac uptake of 18 F-FDG. Methods: Consecutive 18 F-FDG PET patients were recruited into summer and winter cohorts. The protocol was highly standardized; however, data were excluded when scanning took place other than 60 min after injection. Mean and maximum counts per pixel in the cardiac region and cardiac standardized uptake value were determined and correlated with the daily minimum, maximum, and mean temperature (day of scan), mean temperature on the scan day and preceding 2 d (3-d window), and mean temperature 1, 2, 3, and 4 wk before scanning. Results: No statistically significant differences were noted between cohorts (summer and winter) for age, sex, weight, height, or dose. As expected, the summer cohort was associated with statistically higher minimum, maximum, and mean temperatures, longer days, and greater sunlight hours (all P , 0.001). The mean and maximum heart counts were statistically higher in winter than summer (P 5 0.031 and P 5 0.024, respectively). The cardiac standardized uptake value was statistically higher for winter than summer (P 5 0.026). The key factors in cardiac accumulation of 18 F-FDG were the minimum temperature on the day of the scan and the 3-d mean temperature. Conclusion: Cardiac accumulation of 18 F-FDG is influenced by the ambient temperature, in particular the minimum temperature on the day of the scan and the 3-d average temperature before the scan. Further investigation is warranted to examine the impact of this observation on clinical protocols and cardiac 18 F-FDG PET study results. PET with the glucose analog tracer 18 F-FDG evaluates cellular metabolism and is commonly used for the detection and staging of disease in oncology patients (1-3). 18 F-FDG PET is also widely used to assess myocardial viability (4,5). 18 F-FDG PET in oncology has been reported to confront issues with artifactual accumulation of 18 F-FDG in brown adipose tissue (BAT) (6). Warming patients by changing the ambient environment (rather than core temperature) has been reported to successfully reduce BAT activity; however, one recent report noted that warming patients also reduced cardiac uptake of 18 F-FDG (Fig. 1) (6). Although this observation may relate to seasonal variations in cardiac event rates, there may also be important implications for cardiac 18 F-FDG PET diagnostic integrity. Cardiac glucose metabolism depends on numerous factors including substrate availability, cardiac workload, myocardial perfusion, and medication (7). Increased sympathetic activity drives increased metabolic demand for glucose (8,9), and although the connection has yet to be reported in the literature, this investigation hypothesized that t...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 91%

Ambient Temperature and Cardiac Accumulation of 18F-FDG

O’Loughlin

Currie

Trifonovic

et al. 2014

Journal of Nuclear Medicine Technology

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“…In that study, it is confirmed that blood pressure decreases in summer and increases in winter. It is thought to be a physiological phenomenon in which the blood pressure is elevated due to artery contraction when the temperature is low like in winter (Hopstock, 2013). Moreover, from the observation of blood pressure for every season in Japan, it is clear that blood pressure is generally low in summer and high in winter (Takahashi, 1955).…”

Section: Seasonal Fluctuation Of Heart Ratementioning

confidence: 99%

Evaluation of Heart Rate in Daily Life Based on 10 Million Samples Database

Komazawa¹,

Kenichi²,

Lopez³

et al. 2017

GJHS

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This research uses a very-large amount of heart rate data (approximately 10 millions entries) collected on one million persons to investigate heart rate trends in daily life. Trends were examined regarding both human characteristics (gender, age, BMI), and environmental properties (hour of the day, day of the week, season). Concerning the relation between heart rate and gender, women's heart rate trend was significantly lower compared to men's. As for the relation between heart rate and age, on one hand, women's heart rate tends to become lower with aging. On the other hand, men's heart rate tends to keep increasing until the 50's. Also, men's heart rate is lower than women's in the 10's and 20's, the trend becomes opposite from the 30's. In the relation between heart rate and BMI (Body Mass Index), heart rate is significantly higher for users with higher BMI. Regarding diurnal fluctuation of heart rate, it has been confirmed to take its lowest between 3 A.M. and 6 A.M., then increasing regularly until the peak between noon and 3 P.M., after which it decreases during the evening through the night. As for in-week fluctuation, the trend of higher heart rate during the week and lower heart rate during week-ends and holidays has been comfirmed. Specialy, heart rate remarkably increases from Sunday to Monday. Finally, concerning seasonal fluctuation trend, heart rate is decreasing from summer to autumn, and is at his highest level in winter. The results of this research tend to correspond with previous studies that have been carried out on smaller samples and fewer subjects, demonstrating the credibilitay and validity of the data measured by our system. Moreover, on a public health point of view, we can say that it is important to take into account various human properties and spatio-temporal characteristics when having a comparative analysis of people's health distribution. We think the knowledge obtained in this research can be applied practically to the whole society as an indication for health care and various diseases prevention.

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“…жите-лей приарктических территорий [18], выявлены неболь-шие, но статистически значимые сезонные пики зимой уровня АД, ЧСС, ХС, глюкозы и массы тела. Так, прирост уровня ХС составил 0,26 ммоль/л, САД -2 мм рт.ст., а ДАД -1 мм рт.ст.…”

Section: результаты и обсуждениеunclassified