Seasonal variability in fertilization and embryo quality rates in women undergoing IVF

Rojansky, Nathan; Benshushan, Abraham; Meirsdorf, Samuel; Lewin, Aby; Laufer, Neri; Safran, Anat

doi:10.1016/s0015-0282(00)00669-5

Cited by 79 publications

(49 citation statements)

References 23 publications

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“…In northern countries, where a strong seasonal contrast in luminosity exists, the conception rate is decreased during the dark winter months, whereas a peak in conception rate during summer leading to a maximum in birth rate in spring has been observed (60). Moreover, ovulation rates and endometrial receptivity seem to be reduced during long dark winters in northern countries (61). There are several possible explanations for these findings including altered hypothalamic-pituitary axis, brain neurotransmitters such as serotonin, dopamine, and endogenous opioids (60).…”

Section: Vitamin D and Fertility In Humansmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Lerchbaum

Obermayer-Pietsch

2012

European Journal of Endocrinology

336

252

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Background: Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, vitamin D also modulates reproductive processes in women and men. Aim: The aim of this review was to assess the studies that evaluated the relationship between vitamin D and fertility in women and men as well as in animals. Methods: We performed a systematic literature search in Pubmed for relevant English language publications published until October 2011. Results and discussion: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. Vdr knockout mice have significant gonadal insufficiency, decreased sperm count and motility, and histological abnormalities of testis, ovary and uterus. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis. In men, vitamin D is positively associated with semen quality and androgen status. Moreover, vitamin D treatment might increase testosterone levels. Testiculopathic men show low CYP21R expression, low 25(OH)D levels, and osteoporosis despite normal testosterone levels.

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Section: Vitamin D and Fertility In Humansmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Lerchbaum

Obermayer-Pietsch

2012

European Journal of Endocrinology

336

252

View full text Add to dashboard Cite

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“…In northern countries, where there is a strong seasonal contrast in light exposure and UVB-induced vitamin D production in skin, conception rates are decreased during winter months, with rates rising during summer and an increased birth rate in spring (Rojansky et al 1992). Interestingly, ovulation rates and endometrial receptivity also appear to be reduced during long dark winters in northern countries (Rojansky et al 2000), which may be explained in part by seasonal variations in vitamin D levels. With this in mind, several observational studies have investigated the potential impact of vitamin D on in vitro fertilization (IVF), albeit with largely conflicting outcomes.…”

Section: Vitamin D and Trophoblast Function: Clinical Implicationsmentioning

confidence: 99%

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

Ganguly

Tamblyn

Finn-Sell

et al. 2018

Journal of Endocrinology

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Pregnancy is associated with significant changes in vitamin D metabolism, notably increased maternal serum levels of active vitamin D, 1,25-dihydroxyvitamin (1,25(OH) 2 D). This appears to be due primarily to increased renal activity of the enzyme 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) that catalyzes synthesis of 1,25(OH) 2 D, but CYP27B1 expression is also prominent in both the maternal decidua and fetal trophoblast components of the placenta. The precise function of placental synthesis of 1,25(OH) 2 D remains unclear, but is likely to involve localized tissue-specific responses with both decidua and trophoblast also expressing the vitamin D receptor (VDR) for 1,25(OH) 2 D. We have previously described immunomodulatory responses to 1,25(OH) 2 D by diverse populations of VDR-expressing cells within the decidua. The aim of the current review is to detail the role of vitamin D in pregnancy from a trophoblast perspective, with particular emphasis on the potential role of 1,25(OH) 2 D as a regulator of trophoblast invasion in early pregnancy. Vitamin D deficiency is common in pregnant women, and a wide range of studies have linked low vitamin D status to adverse events in pregnancy. To date, most of these studies have focused on adverse events later in pregnancy, but the current review will explore the potential impact of vitamin D on early pregnancy, and how this may influence implantation and miscarriage.

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“…Yie et al (21,22) reported higher concentrations of melatonin and progesterone during the dark season of the year and of oestradiol during the light season from pre-ovulatory follicular fluids. Rojansky et al (4), first correlates the absolute number of light hours with fertilization rate and the result was highest in spring and lowest in autumn. The absolute number of light hours was not included as a weather parameter in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Scientists and epidemiologists have previously reported various IVF/ICSI outcomes in correlation with or without seasonal and weather influences in geological areas distant from the equator such as Canada, Austria, Israel, and United Kingdom (1)(2)(3)(4)(5). Correlations of weather influence on the IVF/ICSI outcome have never been published from a tropical country.…”

Section: Introductionmentioning

confidence: 99%

The influences of weather on patients with different ovarian responses in the treatment of assisted reproductive technology

Chang

Lan

Chen

et al. 2005

J Assist Reprod Genet

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Purpose : The purpose of this study was to evaluate the influences of tropical weather on patients with different ovarian responses in the treatment of assisted reproductive technology. Methods: Six-hundred fourty-seven women underwent their first treatment cycles were retrospectively analyzed. Patients received embryo transfer either 3 days or 5 days after oocyte retrieval, depending on the number and quality of embryos on day-2.Results : Significant correlations were demonstrated in the top quality embryo rates of day-3 and day-5 embryo transfers with temperature, humidity, and atmosphere pressure. The cumulative light hours negatively correlated with the implantation and pregnancy rates of day-3 embryo transfer (−.282 and −.282, respectively), while they positively correlated with those of day-5 embryo transfer (.225 and .224, respectively). Conclusions : These results clearly suggest that weather may exert influences on the outcome of assisted reproductive technology. Patients with different ovarian responses or blastocyst culture and transfer may modify weather influences.

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Seasonal variability in fertilization and embryo quality rates in women undergoing IVF

Cited by 79 publications

References 23 publications

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Vitamin D, the placenta and early pregnancy: effects on trophoblast function

The influences of weather on patients with different ovarian responses in the treatment of assisted reproductive technology

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