Seasonal dynamics of the level of calcidiol in children with cystic fibrosis living in the south of Russia

Abstract

The study included 78 children: 38 patients with cystic fibrosis (CF) (median age 8.2 [4.9-13.8] years) and 40 healthy children (median age 7.66 [2.0-12.1] years), living in the Stavropol region during 2018-2019. Vitamin D sufficiency was assessed by the content of calcidiol -25(OH)D in blood plasma. Seasonal fluctuations in the level of calcidiol during the year in children with CF were more pronounced than in children from the control group -12.2 [7.6-20.2] ng/ml in winter, 29.8 [21.3-37 .9] ng/ml in spring, 33.2 [26.5-39.1] ng/ml in summer and 22.6 [11.4-30.5] ng/ml in autumn, in healthy children the level is 25(OH)D during 2018 was 34.8 [24.8-53.1] ng/ml in winter, 31. 1 [24.6-44.6] ng/ml in spring, 30.4 [23.3-35.3] ng/ml in summer and 41.9 [32.1-55.2] ng/ml in autumn. Serum calcidiol levels were significantly lower in CF children compared to the control children group in winter (p=0.007) and autumn (p=0.04). During the study, the number of children with vitamin D deficiency and severe vitamin D deficiency significantly decreased. At the beginning of the study, severe vitamin D deficiency was detected in 40 % of patients with CF; after adjusting the dose of vitamin received in spring (p<0.005) and summer (p<0.005), it was not found in any of the children. On the contrary, the frequency of normal vitamin D sufficiency increased significantly by 36.7 % in spring (p<0.05), by 50 % in summer (p<0.01), and by 16.7 % in autumn (p>0.05), compared with the first determination of 25(OH)D in winter. Thus, the frequency of vitamin D deficiency in CF patients is statistically significantly higher than in healthy children. The problem of vitamin D deficiency in children with CF is quite relevant due to the low awareness of CF patients and their parents about the critical role of cholecalciferol in this disease.

Relationship between vitamin D sufficiency and interferon-γ levels in children with chronic lung diseases

“…Особенности географического расположения России обусловливают широкое распространение дефицита витамина D у населения, однако у пациентов с МВ высокая частота гиповитаминоза D также определяется дополнительными факторами риска [5,6]. В первую очередь вторичный дефицит жирорастворимых витаминов, в том числе витамина D, при МВ является характерным проявлением мальабсорбции.…”