Seasonal changes in actin and Cdk5 expression in different brain regions of the Yakut ground squirrel (Spermophilus undulatus)

Онуфриев, М. В.; Семенова, Т. А.; Volkova, E. P.; Sergun’kina, M. A.; Yakovlev, A. A.; Zakharova, N. M.; Gulyaeva, N. V.

doi:10.1134/s1819712416020070

Cited by 2 publications

(1 citation statement)

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“…Adipose function was upregulated during euthermia in both grizzly and Chinese alligator 2 2 (Fig 4J). As has been found in the Yakut ground squirrel brain 36 , actin fiber assembly was upregulated in both grizzly and Chinese alligator torpid adipose samples (Fig 4J). Like the results in liver and adipose, terms relating to tissue function were enriched in euthermic muscle in Chinese alligator 1 and bearded dragon (Fig 4L).…”

Section: Resultssupporting

confidence: 80%

Identification of conserved gene expression programs activated in multiple modes of torpor across vertebrate clades

Weir,

Vega,

Busa

et al. 2023

Preprint

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Torpor encompasses adaptations to diverse extreme environmental stressors such as hibernation, aestivation, brumation, and daily torpor. Here we introduce StrokeofGenus, an analytic pipeline that identifies distinct transcriptomic states and conservation of gene expression patterns across studies, tissues, and species. We use StrokeofGenus to study multiple and diverse forms of torpor from publicly available RNA-seq datasets that span eight species and two classes. We identify three transcriptionally distinct states during the cycle of heterothermia: euthermia, torpor, and interbout arousal. We also identify torpor-specific gene expression patterns that are conserved both across tissues and between species with over three hundred million years of evolutionary divergence. We further demonstrate the general conservation of gene expression patterns in multiple forms of torpor, implying a common evolutionary origin for this process. Although here we apply StrokeofGenus to analysis of torpor, it can be used to interrogate any other complex physiological processes defined by transient transcriptomic states.HIGHLIGHTSStrokeofGenus integrates orthologue annotation, non-negative matrix factorization, and transfer learning for cross-species analysis.StrokeofGenus identifies conserved topor-related gene expression patterns across divergent species and cell types.Heterothermia has three distinct transcriptomic states.Torpor-specific gene expression patterns are conserved between species and forms of torpor.

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Section: Resultssupporting

confidence: 80%