“…A total of 16 RCTs ( 21 – 23 , 28 – 30 , 33 , 36 , 48 , 49 , 54 , 56 , 58 – 60 , 64 ) observed the effect of follow-up, the follow-up period was from 1 week ( 29 ) to 40 weeks ( 48 ). Among included studies, 1 study was four-arm trial ( 33 ), 3 RCTs were three-arm ( 22 , 60 , 64 ), the rest studies were two-arm. With regard to comparison, 16 studies applied medication [ antidepressant ( 28 , 34 , 36 , 53 , 55 , 56 ), muscle relaxant ( 27 , 30 , 31 , 35 , 52 , 62 ), analgesics ( 32 , 51 ), antidepressant plus analgesics ( 63 , 64 )], 12 studies used sham acupuncture ( 21 – 23 , 29 , 48 – 50 , 57 – 59 , 61 , 64 ), 2 applied exercise ( 33 , 60 ), 1 utilized relaxation training ( 60 ), 1 applied usual care ( 33 ), 1 was waiting list ( 22 ), 1 was acupuncture plus exercise ( 33 ), and 1 adopted sham acupuncture plus medication ( 54 ).…”