Search for Efficient Chitosan-Based Fungicides to Protect the 15th‒16th Centuries Tempera Painting in Exhibits from the State Tretyakov Gallery

3′-Amino modifications enhance the antifungal properties of N4-alkyl-5-methylcytidines for potential biocides

“…These strains were dominant among the entire microbiome that could be found in STG and they were documented by metagenomic profile characterization. 21 Recently, most of these strains were tested for susceptibility to chitosan 12 and a number of N 4 -alkyl derivatives of 5-methyl-2 0deoxycytidines. 11 Studying the antifungal effects of modifications at different positions of N 4 -alkylcytidines will hopefully shed light on the optimal structure modifications, and 3 0 -amino variations provide a perfect starting point for this purpose.…”

“…4 and 5). 11,12 The 3 0 -dimethylamino derivative with the same decyl substituent at the N 4 position (12a) had a pronounced resemblance to 10a and 14a in inhibitory activity; however, it could not completely inhibit A. creber STG-57, which overcame the treatment and began to grow on day 54 after inoculation (Fig. 4 and 5).…”

“…9,10 In this regard, the challenging task is to develop a new generation of biocides that do not damage the materials of the works of art themselves and at the same time retain their effectiveness against many genera of fungi. 11–13…”

“…9,10 In this regard, the challenging task is to develop a new generation of biocides that do not damage the materials of the works of art themselves and at the same time retain their effectiveness against many genera of fungi. [11][12][13] There are a number of nucleoside derivatives that are being intensively studied as novel antifungal compounds. [14][15][16] The nucleoside class is still new in the field of antibacterial and antifungal protection.…”

High-Yielding Lovastatin Producer Aspergillus terreus Shows Increased Resistance to Inhibitors of Polyamine Biosynthesis

“…The inoculated Petri dishes were incubated for 18 days at 26 • C; measurements were performed every 3 days after inoculation. The inhibitory effects of the compounds were evaluated by ratio of colony growth on CDA medium supplemented with APA, DFMO, Spd, APA + Spd or DFMO + Spd to the growth in the control (CDA medium without any additions), as described previously [21,24]. The formula: growth inhibition % = [(Dc − Dt)/Dc] × 100, where Dc indicates the colony diameter in control set, and Dt indicates the colony diameter in treatment set was used to determine the percent of fungal growth inhibition.…”