Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis

Pollo, Luiz A.E.; Martin, Erlon F.; Machado, Vanessa Rocha; Cantillon, Daire; Wildner, Letícia Muraro; Bazzo, Maria Luiza; Waddell, Simon J.; Biavatti, Maique W.; Sandjo, Louis P.

doi:10.3389/fmicb.2020.622629

Cited by 12 publications

(10 citation statements)

References 42 publications

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“…The tryptophan residues present at the C-terminus of the organized oligopeptides are responsible for reducing the Ag ions [96]. According to the Langmuir Blodgett approach, AgNPs may be synthesized using vitamin E as a reducing agent [97][98][99]. Oleic acid has also been used for the synthesis of biodegradable and green AgNPs [100].…”

Section: Biological or Green Methods For The Synthesis Of Agnpsmentioning

confidence: 99%

A Review on Silver Nanoparticles: Classification, Various Methods of Synthesis, and Their Potential Roles in Biomedical Applications and Water Treatment

Zahoor

Nazir

Iftikhar

et al. 2021

Water

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Recent developments in nanoscience have appreciably modified how diseases are prevented, diagnosed, and treated. Metal nanoparticles, specifically silver nanoparticles (AgNPs), are widely used in bioscience. From time to time, various synthetic methods for the synthesis of AgNPs are reported, i.e., physical, chemical, and photochemical ones. However, among these, most are expensive and not eco-friendly. The physicochemical parameters such as temperature, use of a dispersing agent, surfactant, and others greatly influence the quality and quantity of the synthesized NPs and ultimately affect the material’s properties. Scientists worldwide are trying to synthesize NPs and are devising methods that are easy to apply, eco-friendly, and economical. Among such strategies is the biogenic method, where plants are used as the source of reducing and capping agents. In this review, we intend to debate different strategies of AgNP synthesis. Although, different preparation strategies are in use to synthesize AgNPs such as electron irradiation, optical device ablation, chemical reduction, organic procedures, and photochemical methods. However, biogenic processes are preferably used, as they are environment-friendly and economical. The review covers a comprehensive discussion on the biological activities of AgNPs, such as antimicrobial, anticancer anti-inflammatory, and anti-angiogenic potentials of AgNPs. The use of AgNPs in water treatment and disinfection has also been discussed in detail.

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Section: Biological or Green Methods For The Synthesis Of Agnpsmentioning

confidence: 99%

A Review on Silver Nanoparticles: Classification, Various Methods of Synthesis, and Their Potential Roles in Biomedical Applications and Water Treatment

Zahoor

Nazir

Iftikhar

et al. 2021

Water

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“…IBC can bind well to the surface protein SrtA of S. mutans, thus showing an inhibitory effect on S. mutans (Salmanli, Tatar Yilmaz, & Tuzuner, 2021; Son, Kim, Oh, & Bae, 2020). IBC also has certain antibacterial activity against Mycobacterium tuberculosis (Chiang et al, 2010; Pollo et al, 2020). IBC can bind to PDHE1 of magnaporthe grisea to inhibit carbohydrate metabolism and eventually lead to the gradual destruction and death of mycelium cells (Li et al, 2021).…”

Section: Pharmacological Effects Of Ibcmentioning

confidence: 99%

Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms

Xing

Meng

Wang

2022

Phytotherapy Research

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Isobavachalcone (IBC), also known as isobapsoralcone, is a natural flavonoid widely derived from many medicinal plants, including Fabaceae, Moraceae, and so forth. IBC has been paid more and more attention by researchers in recent years due to its pharmacological activity in many diseases. This review aims to describe in detail the plant sources, pharmacokinetics, toxicity, pharmacological activities, and molecular mechanisms of IBC on various diseases. We found that IBC can be obtained not only by extraction but also by chemical synthesis. Pharmacokinetic studies have shown that IBC has low bioavailability, but can penetrate the blood–brain barrier and is widely distributed in the brain. Its pharmacological activities mainly include anticancer, antibacterial, anti‐inflammatory, antiviral, neuroprotective, bone protection, and other activities. In particular, IBC shows strong anti‐tumor and anti‐inflammatory therapeutic potential due to its anti‐cancer and anti‐inflammatory activities. However, due to its hepatotoxicity, there may be more drug interactions. Therefore, more and more in‐depth studies are needed for its clinical application. Mechanically, IBC can induce the production of reactive oxygen species (ROS), inhibit AKT, ERK, and Wnt pathways, and promote apoptosis of cancer cells through mitochondrial or endoplasmic reticulum pathways. IBC can inhibit the NF‐κB pathway and the production of multiple inflammatory mediators by activating NRF2/HO‐1 pathway, thus producing anti‐inflammatory effects. Moreover, we discussed the limitations of current research on IBC and put forward some new perspectives and challenges, which provide a strong basis for clinical application and new drug development of IBC in the future.

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“…Irregular ATBD consumption can lead to a pause of Mtb in its defense process against ATBD and contribute to the high drug resistance. Thus, Brazilin is an anti-tuberculosis through an indirect antimicrobial mechanism because the brazilin compound is not working on the physiological structure of Mtb [35].…”

Section: The Ability Of Brazilin Compounds As Iron Chelatesmentioning

confidence: 99%

Antituberculosis Activity and Iron Chelation Ability of Brazilin Isolated from Caesalpinia Sappan L.

Safitri¹,

Chaidir²,

Kuntana³

et al. 2022

International Journal on Advanced Science, Engineering and Information Technology

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The present study was conducted to evaluate the anti-tubercular activity of Brazilin and to know the role of iron chelation on the anti-tuberculosis activity of Brazilin. Anti-tuberculosis activity in vitro was tested through MIC values and a reduction in the number of Mtb bacterial cells. The MIC and MBC tests utilized extent technique comprising four treatment groups; the positive control (Lowenstein-Jensen medium inoculated with Mtb), the negative control (LJ medium), the anti-tuberculosis drugs (rifampicin, isoniazid, ethambutol, and streptomycin), and Brazilin at concentration 1, 2, 4, 8, 16, 32, 64, 128, 256, 512, and 1024 ppm that were watched for about eight weeks. The iron chelation capability was assessed using atomic absorption spectrophotometer. The results indicated that the MIC from Brazilin is 128 ppm and MBC of 256 ppm. Brazilin at 128 ppm showed iron chelation of 32.96% capacity and can reduce up to 72% Mtb cells in 10 -3 inoculum dilution. Iron levels at Brazilin 128 ppm (MIC) are higher than iron levels at concentrations of 256 ppm (MBC), indicating that Brazilin binds to iron. The binding of iron by Brazilin results in the unavailability of iron for Mtb, and causes suppression of Mtb growth, further resulting in Mtb cell death. These results exhibit that Brazilin can be used as an iron-chelating agent that might be advantageous in treating and controlling mycobacteria infection.

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Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis

Cited by 12 publications

References 42 publications

A Review on Silver Nanoparticles: Classification, Various Methods of Synthesis, and Their Potential Roles in Biomedical Applications and Water Treatment

A Review on Silver Nanoparticles: Classification, Various Methods of Synthesis, and Their Potential Roles in Biomedical Applications and Water Treatment

Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms

Antituberculosis Activity and Iron Chelation Ability of Brazilin Isolated from Caesalpinia Sappan L.

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