Search for a natriuretic mechanism sensitive to sodium in the brain of the monkey.

Kumar, M. Sunil; Swaminathan, Sundararaman

doi:10.1113/jphysiol.1977.sp012060

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…Implantation of cannula in the brain. Stereotaxic surgery for cannulating the third ventricle has been described in detail earlier (Kumar & Swaminathan, 1977). The following modifications were introduced in this work.…”

Section: Introductionmentioning

confidence: 99%

“…Urografin (Schering AG, Berlin/Bergkamen) (P1. 1) and in all monkeys by injecting bromophenol blue to stain the ventricular ependyma (Kumar & Swaminathan, 1977) under anaesthesia before post mortem examination.…”

Section: Introductionmentioning

confidence: 99%

“…METHODS 1. Female rhesus monkeys weighing between 3 and 4 kg were maintained as described earlier (Kumar & Swaminathan, 1977).…”

Section: Introductionmentioning

confidence: 99%

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Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.

Swaminathan¹

1980

The Journal of Physiology

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SUMMARY1. ADH secretion was studied in trained, preoperated conscious monkeys undergoing water diuresis after administration of isosmolar hypertonic solutions of different substances into any one of the following sites: (i) anterior third ventricle, (ii) the hypothalamus, just anterior to the third ventricle and (iii) common carotid artery.2. Free water clearance was continuously monitored and the ADH released was measured by bio-assay on the same animals after administering graded doses of standard arginine vasopressin in a comparable manner.3. Intraventricular infusions of hypertonic solutions of NaCl or Na acetate released significant amounts of ADH while sucrose or mannitol of comparable osmolality were ineffective. Graded increases in the concentration of NaCl infused into the c.s.f. resulted in secretion of ADH proportional to log Na concentration.4. Infusion of the same hypertonic solutions into the anterior hypothalamus released ADH, though Na salts were more effective than the sugars.5. Hypertonic solutions of NaCl, Na acetate, sucrose or mannitol were effective in releasing ADH when injected via the carotid artery, but hypertonic solutions of NaCl were significantly more effective than the other solutions.6. These findings may be explained by the hypothesis that the 'osmoreceptors' of Verney are Na sensitive receptors composed of dendrites innervating the specialized ependyma of the anterior part of the third ventricle.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.

Swaminathan¹

1980

The Journal of Physiology

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“…Kumar and Swaminathan (11). did not observe a natriuresis in the conscious monkey undergoing a water diuresis when one Molar sodium chloride was infused into the third ventricle at the rate of 0.01 ml/min for 30 min.…”

Section: Introductionmentioning

confidence: 96%

Lack of evidence for a cerebral sodium modulating mechanism in the monkey

Gilmore

1987

Basic Res Cardiol

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Summary: Experiments were carried out in seven conscious macaque monkeys undergoing a water diuresis to determine the effects of raising carotid blood sodium concentration on renal sodium excretion and free water clearance. On separate days each animal received an intracarotid infusion of hypertonic sodium chloride (90 Eq NaCl/kg. body wt./min) for 5 to 10 rain, the same hypertonic infusion intravenously, and an intracarotid infusion of isotonic NaCI. None of the infusions produced a change in sodium excretion. However, the intracarotid hypertonic infusion produced a sustained decrease in free water excretion while the other infusion did not. Creatinine clearance was not affected by any of the infusions. The results of these experimcnts support the view that while the brain of the primate contains an osmotic sensing mechanism it does not contain a mechanism which modulates sodium excretion.

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Intracerebroventricular angiotensin II increases arterial blood pressure in rhesus monkeys by stimulation of pituitary hormones and the sympathetic nervous system

et al. 1982

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Intracerebroventricular injections of angiotensin II in anesthetized rhesus monkeys increase systemic blood pressure and heart rate. These effects are accompanied by an increase in plasma ADH, cortisol, adrenaline and noradrenaline. Angiotensin II may participate in central mechanisms of blood pressure regulation by its stimulatory effect on the sympathetic nervous system, on ADH and on ACTH release in primates.

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Search for a natriuretic mechanism sensitive to sodium in the brain of the monkey.

Cited by 3 publications

References 24 publications

Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.

Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.

Lack of evidence for a cerebral sodium modulating mechanism in the monkey

Intracerebroventricular angiotensin II increases arterial blood pressure in rhesus monkeys by stimulation of pituitary hormones and the sympathetic nervous system

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