Abstract:Summary: Experiments were carried out in seven conscious macaque monkeys undergoing a water diuresis to determine the effects of raising carotid blood sodium concentration on renal sodium excretion and free water clearance. On separate days each animal received an intracarotid infusion of hypertonic sodium chloride (90 Eq NaCl/kg. body wt./min) for 5 to 10 rain, the same hypertonic infusion intravenously, and an intracarotid infusion of isotonic NaCI. None of the infusions produced a change in sodium excretion… Show more
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