Sealing Choroidal Perforations With Cyanoacrylate Adhesives

Seelenfreund, Morton H.; Refojo, Miguel F.; Schepens, Charles L.

doi:10.1001/archopht.1970.00990030619018

Cited by 24 publications

(11 citation statements)

References 8 publications

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“…A number of complications have been reported such as cataract formation, corneal infiltration, granulomatous keratitis, glaucoma, and retinal toxicity. [6][7][8][9][10][11][12][13][14] Cyanoacrylate glues are used "off-label" but have proven to be an effective therapeutic option in certain ophthalmic settings such as sealing small corneal perforations (1 mm) and preemptive treatment of progressive corneal thinning disorders. 5,7,[15][16][17][18][19] An effective polymer adhesive for repairing corneal wounds must meet a number of design requirements.…”

Section: Introductionmentioning

confidence: 99%

Designing hydrogel adhesives for corneal wound repair

2007

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Today, corneal wounds are repaired using nylon sutures. Yet there are a number of complications associated with suturing the cornea, and thus there is interest in an adhesive to replace or supplement sutures in the repair of corneal wounds. We are designing and evaluating corneal adhesives prepared from dendrimers -single molecular weight, highly branched polymers. We have explored two strategies to form these ocular adhesives. The first involves a photocrosslinking reaction and the second uses a peptide ligation reactions to couple the individual dendrimers together to from the adhesive. These adhesives were successfully used to repair corneal perforations, close the flap produced in a LASIK procedure, and secure a corneal transplant.

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Section: Introductionmentioning

confidence: 99%

Designing hydrogel adhesives for corneal wound repair

2007

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“…[5][6][7][8][9][10][11] However, the limitations of this system include difficult application techniques, limited effectiveness, discomfort, toxicity, and lack of biodegradation. 9,[12][13][14][15][16][17][18][19] Complications with cyanoacrylates have also been reported and include cataract formation, corneal infiltration, granulomatous keratitis, glaucoma, and even retinal toxicity. [15][16][17][18] Fibrin-based sealants have also been evaluated for repair of ocular wounds.…”

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confidence: 99%

“…9,[12][13][14][15][16][17][18][19] Complications with cyanoacrylates have also been reported and include cataract formation, corneal infiltration, granulomatous keratitis, glaucoma, and even retinal toxicity. [15][16][17][18] Fibrin-based sealants have also been evaluated for repair of ocular wounds. Fibrin sealants were originally developed for vascular applications but have been used off label for ophthalmic applications.…”

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confidence: 99%

Photo Cross-linkable Biodendrimers as Ophthalmic Adhesives for Central Lacerations and Penetrating Keratoplasties

Degoricija

Johnson

Wathier

et al. 2007

Invest. Ophthalmol. Vis. Sci.

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“…Since then, numerous reports on cyanoacrylate tissue adhesives have been published. [1][2][3][4][5][6][7]9,[19][20][21][22][23][24][25][26] However, the cyanoacrylate glue polymerizes rapidly, and it does not spread well over tissue. In addition, if there is residual water on the retina, the glue polymerizes as a fl oating membrane over the retina.…”

Section: Discussionmentioning

confidence: 99%