Sea Cucumber Stichopus japonicus Hydrolysate Alleviates Late-onset-hypogonadism in Aged SD Rats

Lim, Jong‐Min; Kim, Young Suk; Cho, Hyung-Rae; Lee, Kwang Ho; Yoon, Il Joo; Kim, Sung Kew; Kim, Myoung Seok; Choi, Jae‐Suk

doi:10.1007/s13530-019-0418-0

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…However, it could not reduce the intracellular ROS in the model, which implied that the active compounds in the saponin-rich extract might cause the direct modulation of ageing pathways, rather than a scavenging effect upon the free radicals that accumulate in animals (Kitisin et al, 2019). Lim et al (2019) found that the hydrolysate of sea cucumber Stichopus japonicus could significantly increase the serum testosterone level in the male rat model and could be considered very useful as an andropause-relief agent (Lim et al, 2019). A recent study further reported that protein hydrolysates of Stichopus japonicas could be a bioactive antiageing agent.…”

Section: Ageing and Memory Impairmentsmentioning

confidence: 94%

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

et al. 2022

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Sea cucumbers are amongst the highest value seafoods available commercially, especially in the south-east Asian region, primarily due to their nutritional and health benefits as applied in Traditional Chinese Medicine. While the majority of studies for nutritional products derived from sea cucumber compounds have been conducted in vitro, the number of in vivo and evidence-based human clinical studies are limited. This review has critically assessed the advances in in vivo and clinical studies of sea cucumber-derived bioactives (both extracts and compounds) via a comprehensive literature research on papers published in the last ten years from 2012-2021. Sea cucumber-derived compounds were reported to have the following activities: anticancer, antihyperlipidemic, antihyperglycemic, anti-inflammatory, anticoagulant/antithrombotic, antioxidant, and antihypertension, immunomodulatory, wound healing and as treatments for Alzheimer’s and Parkinson’s diseases. These active compounds include triterpene glycosides (saponins), fucosylated chondroitin sulfate (FCS), cerebrosides, glycosaminoglycan, fucoidan, phospholipids, polysaccharides, peptides, long-chain bases, Frondanol A5, acid mucopolysaccharide, and phosphatidylcholines. Gaps, challenges and future directions have been identified and discussed separately to progress different areas of research and to further scientific validation, development and application of sea cucumbers for human health and nutritional products.

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Section: Ageing and Memory Impairmentsmentioning

confidence: 94%

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

et al. 2022

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“…The saponin content was measured by pulverising the prepared red ginseng using a grinder (HMF-3250S; Hanil Electric Co., Ltd., Seoul, Korea), followed by hot water extraction for 4 h using an autoclave (DA-AC-80; Donga Science, Siheung-si, Korea) at 100 ± 5°C, filtration using a 110 nm filter (No. 2; Advantec Toyo Kaisha, Ltd., Tokyo, Japan), vacuum concentration using a vacuum evaporator (RE-2000E; Dooyoug HI-TECH, Seoul, Korea), and lyophilised powder preparation using a freeze dryer (Lyovapor L200; BÜCHI Labortechnik AG, Flawil, Switzerland) and a vibrating body (GY-200; Guan Yeu Machinery Factory, Chang-Hua Hsien, Taiwan) with a 60-mesh according to the methods provided by the Health Functional Food Code (KFDA 2012) and Lim et al (2019). In this study, the ginsenoside standards used were ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1, Rg2, Rg3 (20R), and Rg3 (20S) (Ambo Institute, Daejeon-si, Korea).…”

Section: Methodsmentioning

confidence: 99%

Alteration in ginsenoside and cordycepin content by solid-state fermentation of red ginseng with Cordyceps militaris

Kim¹,

Lim²,

Ku³

et al. 2021

Czech J. Food Sci.

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We aimed to increase the ginsenosides present in fermented red ginseng and enhance cordycepin production by Cordyceps militaris using solid-state fermentation. After 50 days of fermentation, red ginseng solid-state fermented with C. militaris demonstrated considerably higher contents of Rb3 (9.16%), Rd (513.93%), Rg2 (63.12%), Rg3 (20R; 112.53%), and Rg3 (20S; 101.17%) than untreated red ginseng. As the fermentation time increased, the production of cordycepin gradually increased, yielding approximately 34.8 mg kg<sup>–1</sup> of cordycepin after 50 days of fermentation. In conclusion, red ginseng fermented by C. militaris could be used as natural herbal medicine or dietary supplement with several health-beneficial effects.

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“…Natural products to relieve male menopause, such as sea cucumber hydrolysate, in moderate doses can increase serum testosterone levels in elderly rats and can be used as an adjuvant treatment to improve male menopausal symptoms. [185] The pharmacological activity and pathway of A. japonicus are shown in Table 4.…”

Section: Alleviate Symptoms Of Male Andropausementioning

confidence: 99%

Chemical substances and their activities in sea cucumber Apostichopus japonicus: A review

Lu,

Wang,

et al. 2023

Archiv der Pharmazie

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Apostichopus japonicus, also known as Stichopus japonicus, with medicinal and food homologous figures, is a globally recognized precious ingredient with extremely high nutritional value. There is no relevant review available through literature search, so this article selects the research articles through the keywords “sea cucumber” and “Apostichopus japonicus (Stichopus japonicus)” in six professional databases, such as Wiley, PubMed, ScienceDirect, ACS, Springer, and Web of Science, from 2000 to the present, summarizing the extraction, isolation, and purification methods for the four major categories (polysaccharides, proteins and peptides, saponins, and other components) of the A. japonicus chemical substances and 10 effective biological activities of A. japonicus. Included are anticoagulation, anticancer/antitumor activities, hematopoiesis, regulation of gut microbiota, and immune regulatory activities that correspond to traditional efficacy. Literature support is provided for the development of medicines and functional foods and related aspects that play a leading role in future directions.

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Sea Cucumber Stichopus japonicus Hydrolysate Alleviates Late-onset-hypogonadism in Aged SD Rats

Cited by 3 publications

References 19 publications

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

In Vivo and Clinical Studies of Sea Cucumber-Derived Bioactives for Human Health and Nutrition From 2012-2021

Alteration in ginsenoside and cordycepin content by solid-state fermentation of red ginseng with Cordyceps militaris

Chemical substances and their activities in sea cucumber Apostichopus japonicus: A review

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