Sea cucumber ( Isostichopus badionotus ) body-wall preparations exert anti-inflammatory activity in vivo

Olivera‐Castillo, Leticia; Grant, George; Kantún-Moreno, Nuvia; Acevedo-Fernández, Juan José; Puc-Sosa, Marili; Montero, Jorge; Olvera‐Novoa, Miguel A.; Negrete-León, Elizabeth; Santa‐Olalla, Jesús; Ceballos-Zapata, Julio; Bercansil, Mia C.M.; Merca, Florinia E.; Lindsay-Edwards, John; Puerto-Castillo, Cesar; Gil-Zamorano, Judit; Fernández-Herrera, María A.; Pérez-Tapia, Mayra; Dávalos, Alberto; Rodríguez-Canul, Rossanna

doi:10.1016/j.phanu.2018.03.002

Cited by 14 publications

(9 citation statements)

References 29 publications

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“…FCS from I. badionotus ameliorates hyperlipidaemia and metabolic syndromes in mice [ 22 , 23 ]. Given our original finding that I. badionotus meal was both hypolipidemic and anti-inflammatory in animal models [ 6 , 7 ], the present observations that I. badionotus FCS suppressed skin and intestinal inflammation is not inconsistent with the findings of Li et al [ 22 , 23 ], and indicates that I. badionotus FCS has a broad spectrum of health-promoting actions in vivo.…”

Section: Discussionsupporting

confidence: 75%

“…I. badionotus body wall has potent anti-inflammatory actions in vivo [ 6 , 7 ]. Here we show that these properties are due, at least in part, to FCS, one of its major extractable components.…”

Section: Discussionmentioning

confidence: 99%

“…Adult Isostichopus badionotus (Selenka, 1867) were collected from the seafloor off the coast of Sisal, Yucatan, Mexico (SAGARPA permit No. DGOPA/1009/210809/08761) and processed as before to obtain desalted, lyophilized sea cucumber meal [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Histology scores for ear samples were generated by two independent pathologists and averaged for analysis. Briefly, samples were evaluated for the presence of neutrophil infiltration and edema, and each factor deemed to be either null, slight, moderate or intense [6,7]. Numerical values were assigned to each intensity: null (0); slight (1); moderate (2); and intense (3).…”

Section: Histological Analysis Of Ear Samplesmentioning

confidence: 99%

“…Two studies have established that I. badionotus from the Yucatan Peninsula has potential health-promoting effects. Diets containing the I. badionotus body wall were hypo-cholesterolaemic for rats [ 6 ]. In addition, they substantially altered gene expression in the rat intestine by down-regulating pro-inflammatory genes and up-regulating genes essential for gut barrier integrity and repair [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo

et al. 2020

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Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical genes, including NF-ĸB, TNFα, iNOS, and COX-2, and attenuated inflammation and tissue damage caused by TPA in a mouse ear inflammation model. It also mitigated colonic colitis caused in mice by dextran sodium sulfate. FCS from I. badionotus of the Yucatan Peninsula thus had strong anti-inflammatory properties in vivo.

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