Major yolk protein from sea cucumber (Stichopus japonicus) attenuates acute colitis via regulation of microbial dysbiosis and inflammatory responses

Feng, Jianhui; Zhang, Lina; Tang, Xue; Wei, Hu; Zhou, Peng

doi:10.1016/j.foodres.2021.110841

Cited by 11 publications

(6 citation statements)

References 45 publications

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“…In this study, surprisingly authors observed S. japonicus major yolk protein has the potential to improve the health of colitis in dextran sulfate sodium-induced induced colitis mice. According to the results, major yolk protein prevents tissue damage, diminished occult diarrhea and bleeding, promotes anti-inflammatory cytokines, and increase the contents of total short-chain fatty acids (Feng et al, 2022). Based on the above in vivo and in vitro studies it is clear that regular consumption of sea cumbers have the potential to improve the immune system to fight against inflammatory diseases.…”

Section: Anti-inflammatory Activities Reported From Sea Cucumbersmentioning

confidence: 99%

“…Taken together these results suggest that sea cucumbers have strong antiinflammatory properties that can be used as a functional food for the prevention of inflammation-associated disorders. In another study, Feng et al (2022) attempted to evaluate the acute colitis inhibitory properties of major yolk protein from sea cucumber (S. japonicus) using dextran sulfate sodium-induced colitis mice model (C57BL/6J male mice). In this study, surprisingly authors observed S. japonicus major yolk protein has the potential to improve the health of colitis in dextran sulfate sodium-induced induced colitis mice.…”

Section: Anti-inflammatory Activities Reported From Sea Cucumbersmentioning

confidence: 99%

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Bioactive secondary metabolites in sea cucumbers and their potential to use in the functional food industry

Sanjeewa¹,

Herath²

2023

Fish Aquat Sci

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The bioactive secondary metabolites produced by sea cucumbers are very diverse with differences in composition, linkages, molecular weight, and various functional properties. Due to their physicochemical properties, these bioactive molecules in sea cucumbers have found applications in various market segments such as functional foods and cosmetics. Sea cucumber side dishes are a prominent food item in traditional cuisine in East Asian countries such as South Korea, China, and Japan. In addition, many studies have reported that the consumption of sea cucumbers can reduce the risk of cardiovascular disease, the pathogenesis of cancer cells, chronic inflammatory diseases, etc. In particular, many studies have recently reported the potential of sea cucumbers to develop functional products to reduce inflammation, oxidative stress, diabetes, and cancer. Additionally, these bioactive properties associated with sea cucumbers make them ideal compounds for use as functional ingredients in functional food products. However, no report has yet reviewed the properties of sea cucumbers related to functional foods. Therefore, in this review, the primary focus is given to collecting published scientific data (from 2019 to 2023) on the bioactive properties of sea cucumbers relevant to the functional food industry.

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Section: Anti-inflammatory Activities Reported From Sea Cucumbersmentioning

confidence: 99%

Section: Anti-inflammatory Activities Reported From Sea Cucumbersmentioning

confidence: 99%

Bioactive secondary metabolites in sea cucumbers and their potential to use in the functional food industry

Sanjeewa¹,

Herath²

2023

Fish Aquat Sci

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show abstract

“…Typically, specific microbial populations in the gut produce SCFAs during digestion. Consequently, alterations in SCFA levels are often associated with changes in gut microbiota composition [53] . Building upon these findings, we employed 16S rRNA gene sequencing to investigate the impact of SPP on the gut microbiota of UC mice.…”

Section: Spp Can Increase the Content Of Scfas In The Intestines Of U...mentioning

confidence: 99%

Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

Zhou,

Wang,

Duan

et al. 2024

Food Science and Human Wellness

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The anti-inflammatory properties of silkworm pupa peptide (SPP) have been recognized for their potential benefits in colitis treatment. However, the underlying mechanism of SPP in colitis animal models remains unclear. The objective of our work was to investigate the improving effect and the mechanism of action of SPP on a mouse model of dextrose sodium sulfate (DSS)-induced colitis. The findings suggested that SPP effectively eased ulcerative colitis (UC) symptoms in mice by decreasing disease activity index, ameliorating histopathological injury, and decreasing serum and colonic markers of inflammation. In addition, our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1 (ZO-1), claudin-1, claudin-3, occludin, and adherens junction protein E-cadherin1. Further, SPP supplementation enhanced the concentration of short-chain fatty acids and positively altered the makeup of the gut bacteria in the mice's gut. These findings underscore SPP's ability to slow the progression of colitis and point to its possible use as a functional component in dietary supplements for the prevention of early-stage colitis.

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“…The sulfated polysaccharide from sea cucumber (SCSP) is considered one of the most critical bioactive components of sea cucumber, and it is mainly composed of fucosan sulfate and fucolysated chondroitin sulfate [ 1 ]. In recent years, it has been reported that SCSP has biological activities, such as anti-inflammatory [ 2 ], anticancer [ 3 ], hypoglycemic [ 4 , 5 ], anticoagulant [ 6 , 7 ], and antioxidant properties [ 8 ]. Among them, the in vitro, antioxidant activity of SCSP has been well documented, and previous studies [ 9 , 10 , 11 ] have shown that SCSP has a strong ability to clear DPPH, hydroxyl, and superoxide radicals.…”

Section: Introductionmentioning

confidence: 99%

Sea Cucumber Polysaccharide from Stichopus japonicu and Its Photocatalytic Degradation Product Alleviate Acute Alcoholic Liver Injury in Mice

Song,

Yan

et al. 2024

Foods

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To prevent alcoholic liver disease, the addition of bioactive substances to the alcoholic drink Baijiu has been considered a feasible option. In the present study, the hepatoprotective effects of a sea cucumber sulfated polysaccharide (SCSP) isolated from Stichopus japonicu were investigated. Moreover, in order to enhance its solubility in an alcohol solution, it was depolymerized using a photocatalytic reaction, and the photocatalytic degradation products (dSCSPs) with an average molecular weight of less than 2 kDa were studied and compared with SCSP. They were characterized by a series of chemical and spectroscopy methods and the oligosaccharide fragments in the dSCSP were further identified by HPLC-MSn analysis. Then, the in vivo experiment showed that the addition of SCSP or dSCSP to Baijiu could alleviate alcoholic liver injury in mice. Further analysis also revealed their protective effect in reducing oxidative stress damage and their regulation of the metabolism of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in the liver. Of note, dSCSP was more effective at reducing the level of malondialdehyde in the liver. These findings indicate that the addition of sea cucumber polysaccharide or its low-molecular-weight derivative in Baijiu has the potential to alleviate alcoholic liver injury.

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Major yolk protein from sea cucumber (Stichopus japonicus) attenuates acute colitis via regulation of microbial dysbiosis and inflammatory responses

Cited by 11 publications

References 45 publications

Bioactive secondary metabolites in sea cucumbers and their potential to use in the functional food industry

Bioactive secondary metabolites in sea cucumbers and their potential to use in the functional food industry

Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

Sea Cucumber Polysaccharide from Stichopus japonicu and Its Photocatalytic Degradation Product Alleviate Acute Alcoholic Liver Injury in Mice

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