scyllo-Inositol, Preclinical, and Clinical Data for Alzheimer’s Disease

Ma, Keran; Thomason, Lynsie A.M.; McLaurin, JoAnne

doi:10.1016/b978-0-12-394816-8.00006-4

Cited by 67 publications

(51 citation statements)

References 110 publications

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“…Changes in the synthesis, breakdown or density of cell membranes have been associated with increases in the 1 H-MRS GPC and Cho signals (Maddock and Buonocore 2012). It is not surprising that cerebral alteration in the levels of such metabolites has been suggested to be involved in the development of neurodegenerative (Bitsch et al 1999;Dedeoglu et al 2004;Chang et al 2013;Lopes et al 2013;Ma et al 2012;Perry et al 1975;Yang et al 2011) and psychiatric (Chang et al 2013;Chen et al 2009;Forton et al 2008;Hemanth Kumar et al 2012) disorders.…”

Section: Discussionmentioning

confidence: 94%

Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2

Righi

Schenetti

Mucci

et al. 2015

J Neuroimmune Pharmacol

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Interferon (IFN)-α2 is an extensively therapeutically used pro-inflammatory cytokine. Though its efficacy in controlling viral replication and tumor cells proliferation, administration of IFN-α2 is often associated with the development of central side effects. Magnetic resonance spectroscopy studies have demonstrated that IFN-α2 administration affects brain metabolism, however the exact nature of this effect is not completely known. We hypothesized that IFN-α2 can affect metabolic activity of human neuron-like SH-SY5Y cells which possess many characteristics of neurons and represent one of the most used models for studying mechanisms involved in neurotoxicity or neuroprotection. To test our hypothesis we have characterized the metabolic signature of live SH-SY5Y, and their conditioned media, after 24 and 72 h of exposure to vehicle or IFN-α2 (100 ng/ml) by using High Resolution-Magic Angle Spinning (HR-MAS) Nuclear Magnetic Resonance (NMR) spectroscopy. Our results revealed that 1) the use of HR-MAS NMR is ideally suitable for the characterization of the metabolic profile of live cells and their conditioned media without extraction procedures; and 2) a 72 h exposure to IFN-α2 increases the level of metabolites involved in maintaining energetic (including creatine and lactate) and osmotic (such as myo-inositol, scyllo-inositol, taurine and glycerophosphorylcholine) balances in neuron-like cells and of metabolic waste products (namely lactate, ethanol and acetate), glycine and glutamine in their growth media. These results may contribute to gain more knowledge about the IFN-α2 induced effect on the brain and support the interpretation of magnetic resonance spectroscopy studies performed in humans.

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Section: Discussionmentioning

confidence: 94%

Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2

Righi

Schenetti

Mucci

et al. 2015

J Neuroimmune Pharmacol

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“…Scyllitol is an osmolyte known to be present in the blood of teleosts and other deep-sea animals and which may function as a cryoprotectant (Yancey et al, 2002(Yancey et al, , 2004. It has also received significant interest for its role in brain chemistry across species from fish to mammals, and in particular for its potential as a therapeutic for Alzheimer's disease, likely related to its stabilization of and interaction with proteins (Fenili et al, 2010;Ma et al, 2012). The relevance of these increased sugar alcohol levels, particularly as related to prolonged starvation, warrants further study, as this may reflect an unknown metabolic or biochemical response to starvation that has not previously been characterized.…”

Section: Polyol Accumulation Might Be Indicative Of a Currently Unknomentioning

confidence: 94%

“…However, there is fairly little known about polyol levels in fish. The accumulated polyol scyllitol was first discovered in sharks and skates in 1858 by Staedler and Frerichs (Fenili et al, 2010;Ma et al, 2012). It is known that skates have the highest levels of scyllitol in their kidneys and livers.…”

Section: Polyol Accumulation Might Be Indicative Of a Currently Unknomentioning

confidence: 98%

Differential metabolite levels in response to spawning-induced inappetence in Atlantic salmon Salmo salar

Cipriano¹,

Smith

Vermeersch

et al. 2015

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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“…[50] The role of scyllo-inositol in Alzheimer's disease has been the subject of a recent comprehensive review so this aspect of scyllo-inositol science is not reviewed in detail herein. [51] scyllo-Inositol is able to stabilize soluble oligomers of Aβ, the structure of which has been recently described, [52] and prevent the formation of insoluble amyloid fibres.…”

Section: Scyllo-inositol and Neurological Disordersmentioning

confidence: 99%

The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo‐Inositol Chemistry)

2015

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Cell signalling via inositol phosphates, eg the second messenger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comprises a huge field of biology. Of nine 1,2,3,4,5,6-cyclohexanehexol isomers, myo-inositol is pre-eminent, with "other" inositols (cis-, epi-, allo-, muco-, neo-, L-chiro-, D-chiro-and scyllo-) and derivatives rarer or thought not to exist in nature. However, recently, neoand D-chiro-inositol hexakisphosphates were revealed in both terrestrial and aquatic ecosystems, highlighting the paucity of knowledge of the origins and potential biological functions of such stereoisomers, a prevalent group of environmental organic phosphates, and their parent inositols. Some "other" inositols are medically relevant, e.g. scyllo-inositol (neurodegenerative diseases), and D-chiro-inositol (diabetes). It is timely to consider exploration of roles and applications of "other" isomers and their derivatives, likely by exploiting techniques now well developed for the myo-series.

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scyllo-Inositol, Preclinical, and Clinical Data for Alzheimer’s Disease

Cited by 67 publications

References 110 publications

Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2

Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2

Differential metabolite levels in response to spawning-induced inappetence in Atlantic salmon Salmo salar

The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo‐Inositol Chemistry)

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