Scutellaria brevibracteata Stapf and active principles with anti-inflammatory effects through regulation of NF-κB/COX-2/iNOS pathways

Dogan, Zeynep; Telli, Gökçen; Tel, Banu Cahide; Saraçoğlu, İclal

doi:10.1016/j.fitote.2022.105159

Cited by 7 publications

(10 citation statements)

References 42 publications

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“…The authors detected metabolites belong to iridoid derivatives: loganic acid, 6′-O- E -caffeoyl mussenosidic acid, 6′-O- E - p -coumaroyl gardoside, albidoside, and globularin (scutellarioside I). They also found flavonoids, such as luteolin, luteolin 7-O-β-glucuronide, apigenin, 3-O-methyl kaempferol, trihydroxy-dimethoxyflavone, and oroxylin A [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…The phytochemical composition of the plant described only a few articles [ 2 , 16 , 20 , 21 , 22 ], of which, three of them referred to essential oil and volatile compounds [ 2 , 16 , 22 ]. According to previous professional pharmacological studies, Scutellaria brevibracteata Stapf methanolic and aqueous extracts of aerial parts exhibit antioxidant and anti-inflammatory properties [ 20 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Cultures of Scutellaria brevibracteata subsp. subvelutina as a Source of Bioactive Phenolic Metabolites

et al. 2023

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Some of the more than 350 Scutellaria species, such as S. baicalensis and S. lateriflora, have been used in traditional medicine and today play an important role in official phytotherapy. Other species have been less investigated, and their therapeutic potential is unknown. This is one of the few studies on Scutellaria brevibracteata subsp. subvelutina, and the first research of this species’ in vitro cultures. The aim of this study was to establish an in vitro culture and analyse its phytochemical profile and biological activity. In the methanolic extracts from biomass cultured on six solid Murashige and Skoog (MS) medium variants supplemented with different combinations of 6-benzylaminopurine (BAP) and 1-naphthaleneacetic acid (NAA) in the range 0.5–3 mg/L analysed by HPLC, the presence of specific flavonoids (baicalein, baicalin, wogonin, wogonoside, scutellarin, chrysin), phenylpropanoid glycosides (verbascoside, isoverbascoside), and phenolic acids (p-hydroxybenzoic, caffeic, ferulic, m-coumaric acids) was confirmed. The dominant metabolites were wogonoside and verbascoside with the highest content of 346 and 457 mg/100 g DW, respectively. Thus, the extract with the highest content of bioactive metabolites was selected for further research and subjected to evaluation of antioxidant and antimicrobial potential. The extract exhibited good free radical scavenging activity (IC50 = 0.92 ± 0.01 mg/mL) and moderate reducing power and chelating activity. The brine shrimp lethality bioassay proved its lack of biotoxicity. Antimicrobial activity was tested against sixteen strains of Gram-positive and Gram-negative bacteria and fungi. The strongest growth inhibitory activity was observed against Trichophyton tonsurans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro Cultures of Scutellaria brevibracteata subsp. subvelutina as a Source of Bioactive Phenolic Metabolites

et al. 2023

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“…They employed Diclofenac sodium as a control, which inhibited inflammation induced by carrageenan by 74% in the experimental mice. Dogan et al [122] described the therapeutic role of S. brevibracteata in the treatment of inflammation. They sought to decipher the underlying molecular pathways behind stomach inflammatory processes using network pharmacology and molecular docking analysis.…”

Section: Anti-inflammatory Potentialmentioning

confidence: 99%

“…Dogan et al [ 122 ] described the therapeutic role of S. brevibracteata in the treatment of inflammation. They sought to decipher the underlying molecular pathways behind stomach inflammatory processes using network pharmacology and molecular docking analysis.…”

Section: Biological Activities Of Genus Scutellariamentioning

confidence: 99%

Phytochemical Profiling and Bio-Potentiality of Genus Scutellaria: Biomedical Approach

et al. 2022

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Scutellaria (Lamiaceae) comprises over 360 species. Based on its morphological structure of calyx, also known as Skullcap, it is herbaceous by habit and cosmopolitan by habitat. The species of Scutellaria are widely used in local communities as a natural remedy. The genus contributed over three hundred bioactive compounds mainly represented by flavonoids and phenols, chemical ingredients which serve as potential candidates for the therapy of various biological activities. Thus, the current review is an attempt to highlight the biological significance and its correlation to various isolated bioactive ingredients including flavonoids, terpenoids, phenols, alkaloids, and steroids. However, flavonoids were the dominant group observed. The findings of the Scutellaria reveal that due to its affluent basis of numerous chemical ingredients it has a diverse range of pharmacological potentials, such as antimicrobial, antioxidant, antifeedant, enzyme inhibition, anti-inflammatory, and analgesic significance. Currently, various bioactive ingredients have been investigated for various biological activities from the genus Scutellaria in vitro and in vivo. Furthermore, these data help us to highlight its biomedical application and to isolate the responsible compounds to produce innovative medications as an alternative to synthetic drugs.

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“…Recently the use of ayurvedic drugs has gained popularity in clinical research. For instance, a study has shown that Ruellia prostrata (RP) and Ruellia bignoniiflora(RB) herbal medicine and its constituents could have anti-inflammatory and anti-analgesic properties [15] [15], [16]. However, the identification and elucidation of Rueilla active constituent compositive compounds and their molecular mechanism of action in treating of rheumatoid arthritis remain unknown [2], [17], [18].…”

Section: Introductionmentioning

confidence: 99%

An Efficient Weighted Network Centrality Approach for Exploring Mechanisms of Action of the RP-RB Herbal Formula for Treating Rheumatoid Arthritis

Ochieng

Dombi

Hussain

2022

Preprint

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Aim : This study presents an efficient weighted network centrality measureapproach and its application in network pharmacology for exploring mechanismsof action of the Ruellia prostrata (RP) and Ruellia bignoniiflora (RB) herbalformula for treating rheumatoid arthritis. Method: A tripartite network of RP-RB compositive compound-knowntherapeutic targets-putative target genes was first built. The interconnectivityscore was used to prioritizes network candidate network components based ontheir overall connectivity with shared neighborhood network components. A newinterconnectivity based weighted centrality score calculated from traditionalnetwork centrality measure was used identify and explore relationships of themajor network components. The functionality of our proposed method wasdemonstrated by an application in network pharmacology. Result : Network pharmacology results revealed that out of 196 compounds 22were actively interacting with known rheumatoid arthritis therapeutic targets andputative target genes. A multi-level network simulation identifies 33 majorcandidate targets including 8 compositive compounds, 10 therapeutic targets and15 putative target genes. The gene ontology and KEGG pathway enrichmenttarget validation demonstrated that candidate putative target genes were frequently involved in TNF, CCR5, IL-17 and G-protein coupled receptorssignaling pathways which are critical in the progression of rheumatoid arthritis.The molecular docking simulation and molecular descriptor analysis indicatedthat Glyceryl diacetate-2-Oleate, Hexadecanoic acid, 2,3-bis(acetyloxy)propylester, Glycidyl oleate, and Oleoyl chloride had a high binding affinity on theirmajor targets with their molecular descriptor properties indicating their potentialdrug likeliness for the treatment of rheumatoid arthritis. Conclusion : The findings of this study provides promising results that couldlead to design and discovery alternative drug compounds for management andtreatment of rheumatoid arthritis. Although our approach is purely based on insilico method, clinical experiments are still needed to test and validate thehypotheses of our computational methods.

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Scutellaria brevibracteata Stapf and active principles with anti-inflammatory effects through regulation of NF-κB/COX-2/iNOS pathways

Cited by 7 publications

References 42 publications

In Vitro Cultures of Scutellaria brevibracteata subsp. subvelutina as a Source of Bioactive Phenolic Metabolites

In Vitro Cultures of Scutellaria brevibracteata subsp. subvelutina as a Source of Bioactive Phenolic Metabolites

Phytochemical Profiling and Bio-Potentiality of Genus Scutellaria: Biomedical Approach

An Efficient Weighted Network Centrality Approach for Exploring Mechanisms of Action of the RP-RB Herbal Formula for Treating Rheumatoid Arthritis

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