Sculpturing the Architecture of Mineralized Tissues: Tissue Engineering of Bone from Soluble Signals to Smart Biomimetic Matrices

Ripamonti, Ugo; Ramoshebi, Lentsha Nathaniel; Patton, Janet C.; Teare, June; Matsaba, Thato; Renton, Louise

doi:10.1002/3527602410.ch16

Cited by 7 publications

(83 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In marked contrast to the rodent bioassay, the TGF-β isoforms so far tested in our laboratories have shown a marked site and tissuespecific endochondral osteoinductivity in the pri-mate Papio ursinus. Remarkably this occurs in primates only [2,10,12,[20][21][22][23] (Fig. 1C).…”

Section: Species Site and Tissue Specificitymentioning

confidence: 99%

“…1A). The remarkable process of tissue morphogenesis and bone induction in postnatal life is a recapitulation of embryonic development whereby both embryonic development and tissue regeneration are regulated by a select few, highly conserved families of morphogens namely the BMPs/OPs family of the TGF-β superfamily [2,5,6,12,15,16] (Fig. 1A).…”

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

“…morphogenesis [2,6]. Thus these pleiotropic morphogens have potent and diverse effects on cell proliferation, differentiation, motility and matrix synthesis leading ultimately to cartilage and bone differentiation and regeneration [1,2,6,12,14].…”

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

“…Thus osteogenesis can occur via the combined action of several BMPs/OPs resident within the natural milieu of the extracellular matrix of bone [7,[10][11][12] (Fig. 1B).…”

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

“…1C). In this animal model, the induction of bone by TGF-β isoforms is characterised by a marked site and tissue specificity [2,10,12,[20][21][22][23].…”

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

See 4 more Smart Citations

Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues

Ripamonti

2004

J Cellular Molecular Medi

158

View full text Add to dashboard Cite

Bone morphogenetic and osteogenic proteins (BMPs/OPs), members of the transforming growth factor-β (TGF-β) superfamily, are soluble mediators of tissue morphogenesis and induce de novo endochondral bone formation in heterotopic extraskeletal sites as a recapitulation of embryonic development. In the primate Papio ursinus, the induction of bone formation has been extended to the TGF-β isoforms per se. In the primate and in the primate only, the TGF-β isoforms are initiators of endochondral bone formation by induction and act in a species-, site-and tissuespecific mode with robust endochondral bone induction in heterotopic sites but with limited new bone formation in orthotopic bone defects. The limited inductive capacity orthotopically of TGF-β isoforms is associated with expression of the inhibitory Smads, Smad6 and Smad7. In primates, bone formation can also be induced using biomimetic crystalline hydroxyapatite matrices with a specific surface geometry and without the exogenous application of osteogenic proteins of the TGF-β superfamily, even when the biomimetic matrices are implanted heterotopically in the rectus abdominis muscle. The sequence of events that directs new bone formation upon the implantation of highly crystalline biomimetic matrices initiates with vascular invasion, mesenchymal cell migration, attachment and differentiation of osteoblast-like cells attached to the substratum, expression and synthesis of osteogenic proteins of the TGF-β superfamily resulting in the induction of bone as a secondary response. The above findings in the primate indicate enormous potential for the bioengineering industry. Of particular interest is that biomimetic matrices with intrinsic osteoinductivity would be an affordable option in the local context.

show abstract

Section: Species Site and Tissue Specificitymentioning

confidence: 99%

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

“…Thus osteogenesis can occur via the combined action of several BMPs/OPs resident within the natural milieu of the extracellular matrix of bone [7,[10][11][12] (Fig. 1B).…”

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

“…1C). In this animal model, the induction of bone by TGF-β isoforms is characterised by a marked site and tissue specificity [2,10,12,[20][21][22][23].…”

Section: Bone Induction By Tgf-β β Family Membersmentioning

confidence: 99%

See 3 more Smart Citations

Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues

Ripamonti

2004

J Cellular Molecular Medi

158

View full text Add to dashboard Cite

show abstract

Soluble osteogenic molecular signals and the induction of bone formation

2006

View full text Add to dashboard Cite

Recapitulating Development: A Template for Periodontal Tissue Engineering

Ripamonti

2007

Tissue Engineering

View full text Add to dashboard Cite

The induction of bone formation by the soluble osteogenic molecular signals of the transforming growth factor-beta (TGF-beta) superfamily is a critical issue to periodontologists, molecular biologists, and tissue engineers alike, because preclinical studies in primates and clinical trials have demonstrated the bone induction capacity of bone morphogenetic and osteogenic proteins (BMPs/OPs) in clinical context. BMPs/OPs, pleiotropic members of the TGF-beta superfamily, induce de novo endochondral bone formation as a recapitulation of embryonic development and act as soluble signals for tissue morphogenesis sculpting the multicellular mineralized structures of the periodontal tissues with functionally oriented periodontal ligament fibers inserting into newly formed cementum. This paper reviews the induction of the complex tissue morphologies of the periodontal tissues in the nonhuman primate Papio ursinus with furcation defects treated with doses of naturally derived and recombinantly produced human BMPs/OPs. Periodontal tissue regeneration develops as a mosaic structure in which the OPs of the TGF-beta superfamily singly, synergistically, and synchronously initiate and maintain tissue induction and morphogenesis.

show abstract

Sculpturing the Architecture of Mineralized Tissues: Tissue Engineering of Bone from Soluble Signals to Smart Biomimetic Matrices

Cited by 7 publications

References 0 publications

Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues

Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues

Soluble osteogenic molecular signals and the induction of bone formation

Recapitulating Development: A Template for Periodontal Tissue Engineering

Contact Info

Product

Resources

About