Scrub typhus &amp; Dengue Co-infection among patients attending a tertiary care hospital at Puducherry

Saleem, Muhammad A; Gopal, Raja; Shivekar, Sunil; Mangaiyarkarasi, T

doi:10.5958/2394-5478.2016.00035.2

Cited by 4 publications

(3 citation statements)

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“…In the present study, all the children with chikungunya only and chikungunya-scrub typhus coinfection had a fever. A previous study by Saleem et al, in patients with dengue and scrub typhus coinfection, also reported fever in all the cases [ 9 ]. Still, there is no previous published literature to compare chikungunya-scrub typhus coinfection clinical features to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 87%

Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal

Pathak

Chaudhary

Dhakal

et al. 2021

International Journal of Pediatrics

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Objectives. Chikungunya and scrub typhus infection are important causes of undifferentiated fever in tropical zones. The clinical manifestations in both conditions are nonspecific and often overlap. This study compares the clinical manifestations and the outcome of chikungunya with chikungunya-scrub typhus coinfection in children. Methods. A hospital-based observational study was conducted in children below 15 years of age over 16-month duration in 2017-2018. Chikungunya was diagnosed by IgM ELISA. All positive chikungunya cases were subjected to scrub typhus testing, dengue testing, leptospira testing, and malaria testing. Clinical manifestations and outcomes of all patients were recorded. Results. Out of the 382 admitted cases with fever, 11% ( n = 42 ) were diagnosed with chikungunya, and the majority ( n = 30 , 71.4%) were male. Among the 42 chikungunya cases, 17 (40.5%) tested positive for scrub typhus and one positive for falciparum malaria. Out of a total of 42 chikungunya cases, myalgia, nausea/vomiting, headache, abdominal pain, lymphadenopathy, hepatomegaly, splenomegaly, and edema were 81%, 73.8%, 66.7%, 64.3%, 59.5%, 52.4%, 40.5%, and 38.1%, respectively. Besides, altered sensorium (31%), jaundice (26.2%), dry cough (21.4%), shortness of breath (19%), and seizures (16.7%) were other clinical manifestations present in this group of children. Patients with chikungunya-scrub typhus coinfection reported headaches, pain in the abdomen, dry cough, shortness of breath, seizures, and splenomegaly, significantly more ( p value < 0.05) compared to those with chikungunya only. Thirteen (31%) children developed shock, five in the chikungunya group and eight in the chikungunya-scrub typhus coinfection group. Six children in the coinfection group received inotrope. Among the chikungunya-only cases, 22 recovered and one died, whereas in the chikungunya-scrub typhus coinfection group, fourteen recovered and three died. Conclusions. Both the chikungunya and scrub typhus coinfection groups shared many similar clinical manifestations. In children, coinfection with scrub typhus often leads to modification of the clinical profile, complications, and chikungunya outcome.

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Section: Discussionmentioning

confidence: 87%

Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal

Pathak

Chaudhary

Dhakal

et al. 2021

International Journal of Pediatrics

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“…Saleem et al reported 15 cases of scrub typhus coinfection with dengue in adults [3] while Rajendran reported one case of coinfection in the pediatric age group [9]. Previous infection with any one of the agents in the recent past can render a false positive IgM ELISA in the present episode [3].…”

Section: Discussionmentioning

confidence: 99%

“…Coinfection of scrub typhus and dengue in the Indian subcontinent, though rare, has been previously reported. In 2015, Venkategowda et al had published a case series of five such patients, while in 2016 Saleem et al reported 15 similar coinfections [2,3]. Recently, Sapkota et al published similar case in 2017 [4].…”

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confidence: 98%

Scrub Typhus and Dengue Coinfection in a 17-Month-Old Child

Roy¹,

Chakrabartty²

2017

IJCR

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Scrub typhus is reemerging as a worldwide threat. In the tropical countries, where other diseases with overlapping clinical features are abundant, the occurrence of scrub typhus poses to be a significant problem to the clinician. We describe the case of a 17-monthold child who was diagnosed to be having a coinfection of scrub typhus and dengue. Various similar complications such as capillary leakage, thrombocytopenia, and possibility of seizure found in both the diseases, make such a coinfection very risky. The child was managed with oral azithromycin and fluid support. He became afebrile after 60 h and was discharged after 8 days. This case report will alert the pediatricians to anticipate the rare possibility of coinfection with scrub typhus and dengue fever.

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A Case of Coinfection with (H1N1) 2009 Influenza and Scrub Typhus with CNS Involvement

Sahu

Chhotray

et al. 2019

Apollo Medicine

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Scrub typhus & Dengue Co-infection among patients attending a tertiary care hospital at Puducherry

Cited by 4 publications

References 0 publications

Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal

Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal

Scrub Typhus and Dengue Coinfection in a 17-Month-Old Child

A Case of Coinfection with (H1N1) 2009 Influenza and Scrub Typhus with CNS Involvement

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