Scrub typhus, acute respiratory distress, and hemophagocytic lymphohistiocytosis

Correnti, Patrizia; Iaria, Chiara

doi:10.1016/j.ijid.2013.03.006

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…There were only few case reports describing patients co-existed with ARDS and HLH at the same time in literatures. An author illustrated patients with ARDS and HLH that resulted from infection by scrub typhus [8]. Another author presented a patient with SLE who suddenly died of associated ARDS with accidental findings suggestive of hemophagocytic syndrome documented by autopsy [9].…”

Section: Discussionmentioning

confidence: 99%

Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome

Shiu

Lee

et al. 2019

Case Reports in Infectious Diseases

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Acute respiratory distress syndrome (ARDS) and hemophagocytic lymphohistiocytosis (HLH) are accompanied with poor outcome and high mortality when miliary tuberculosis is a causative pathogen for both of them. A patient complicated with ARDS and HLH is unusual in critical care, and few case reports are present in PudMed. Besides, the relationship between HLH and ARDS is still unknown and has not been reviewed in the literature. In this report, we present the case of a 74-year-old Taiwanese woman suffering from pulmonary tuberculosis and miliary tuberculosis, and she developed ARDS and HLH on the 3rd day after admission. We arranged serial laboratory examination, various serum markers, bone marrow aspiration, and bronchoscopy with alveolar lavage for survey; we prescribed empirical antibiotics and antituberculosis medication soon after alveolar lavage showing positive acid-fast stain. She was extubated on hospital day 31 and discharged on hospital day 73. In conclusion, early diagnosis and intervention for underlying disease and intensive bundle care for multiorgan failure are crucial for both ARDS and HLH.

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Section: Discussionmentioning

confidence: 99%

Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome

Shiu

Lee

et al. 2019

Case Reports in Infectious Diseases

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“…If treated in time, the cure rate is high but with a few sequelae. Delayed diagnosis and treatment can lead to serious complications, including disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and hemophagocytic lymphohistiocytosis (HLH) [4] . According to the latest statistics, in the absence of treatment for tsutsugamushi disease, the average mortality of patients can be as high as 70% [5] .…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of Severe Tsutsugamushi Disease Complicated with Hemophagocytic Lymphohistiocytosis

Huang

et al. 2021

PAR

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“… 1 A delay in the diagnosis and treatment can result in severe complications, including disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and hemophagocytic lymphohistiocytosis (HLH). 2 …”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis With Chloramphenicol

et al. 2016

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Scrub typhus is caused by Orientia tsutsugamushi. Any delay in diagnosis can result in delayed treatment and severe complications, including secondary hemophagocytic lymphohistiocytosis, which is rare but potentially fatal.In this paper, the authors present 3 cases of secondary hemophagocytic lymphohistiocytosis associated with scrub typhus, successfully treated with chloramphenicol without additional antineoplastic therapy. All patients cured and achieved complete resolution.This report highlights the effectiveness of chloramphenicol without the need for chemotherapy in the treatment of scrub typhus-associated hemophagocytic lymphohistiocytosis in a pediatric population under the age of 8 years.

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Scrub typhus, acute respiratory distress, and hemophagocytic lymphohistiocytosis

Cited by 4 publications

References 9 publications

Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome

Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome

Clinical Features of Severe Tsutsugamushi Disease Complicated with Hemophagocytic Lymphohistiocytosis

Successful Treatment of Scrub Typhus-Associated Hemophagocytic Lymphohistiocytosis With Chloramphenicol

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