Screening the optimal hierarchical micro/nano pattern design for the neck and body surface of titanium implants

Zhou, Ping; Mao, Feifei; He, Fei; Han, Yu; Li, Hongjiao; Chen, Jing; Wei, Shicheng

doi:10.1016/j.colsurfb.2019.03.045

Cited by 31 publications

(59 citation statements)

References 36 publications

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“…Missing teeth are usually replaced by oral implants 79 . In addition to treatment devices, micro/nanostructures can also help enhance the function of oral implants because natural bone tissues have a micro/nanoscale hierarchical structure with a mineral phase composed of calcium and phosphorus 80 . Therefore, oral implants with surface modifications promote the proliferation and osteogenic differentiation of osteoblasts for osseointegration in bone repair 81 .…”

Section: Treatment Of Oral Diseasesmentioning

confidence: 99%

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

et al. 2021

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Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few years. This review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and ophthalmology. We first summarize the recent progress in this field by examining the available materials and fabrication techniques, device design principles, mechanisms, and biosafety aspects of micro/nanodevices. Following a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment, we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions, including oral cancer, eye wrinkles, keratitis, and infections. Along with the identified key challenges, this review concludes with future directions as a small fraction of vast opportunities, calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology.

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Section: Treatment Of Oral Diseasesmentioning

confidence: 99%

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

et al. 2021

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“…The titanium (Ti) specimens with a diameter of 4 inches were mechanically polished using SiC sandpapers and followed by several cleaning processes using concentrated sulfuric acid, 5% dilute hydrochloric acid and ultrasonic cleaning machine as we recently reported [23] . Micron-scale patterns resemble cell morphology with a height of 2 µm, or 3.6 µm were prepared on the Ti surfaces through the photolithography and ICP etching technology.…”

Section: Fabrication Of Hierarchical Micron/nano Scale Patterns Mimicking Cell Morphology On Ti Surfacesmentioning

confidence: 99%

“…Moreover, these Ti discs were further decorated by nanotubes with a diameter of 85 nm or 55 nm using anodization technology. These preparation processes were the same as we recently described [23] . Finally, the Ti discs were cut into square discs with 3 mm diameter using a laser.…”

Section: Fabrication Of Hierarchical Micron/nano Scale Patterns Mimicking Cell Morphology On Ti Surfacesmentioning

confidence: 99%

“…Human osteoblast-like MG63 cells (MG63 for short), mouse L929 fibroblast cells (L929 for short), and human oral Squamous Cell Carcinoma-derived epithelial cell line (SCC for short) were maintained under standard conditions as mentioned previously [23] . After sterilizing by UV irradiation, Ti discs were placed into each well of 96-well cell culture plates.…”

Section: Cell Viability Assaymentioning

confidence: 99%

“…Moreover, anodization technology has been widely applied to fabricate TiO 2 nanotubes on Ti surfaces to regulate cell behavior by changing nanotubes diameter and cell types. Recently, we researched the effects of various hierarchical micron/nano scale patterns on the growth of implant-healing related cells and bacteria systematically [23] . However, only simple microgroove patterns with different widths and depths were studied.…”

Section: Introductionmentioning

confidence: 99%

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Screening the Optimal Patterned Surfaces Consisting of Cell Morphology Mimicking Micro-pillars and Nanotube Arrays for the Design of Titanium Implants

Zhou

Mao

et al. 2021

J Bionic Eng

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Micron/nano scale topographic modification has been a significant focus of interest in current titanium (Ti) surface design. However, the influence of micron/nano structured surface on cell or bacterium behavior on the Ti implant has rarely been systematically evaluated. Moreover, except for popular microgrooves, little work has been carried out on the reaction of cells to the bionic structure. In this study, several micro-pillars mimicking cell morphology were prepared on Ti surfaces by lithography and contact printing (ICP) method, and they were further decorated with nanotube arrays by anodization technology. These surface modifications remarkablly increased the surface roughness of pristine Ti surface from 91.17 nm ± 5.57 nm to be more than 1000 nm, and reduced their water contact angles from 68.3° ± 0.7° to be 16.9° ± 2.4°. Then, the effects of these hierarchical micron/nano scale patterns on the behaviors of MG63 osteoblasts, L929 fibroblasts, SCC epithelial cells and P. gingivalis were studied, aiming to evaluate their performance in osseointegration, gingival epithelial sealing and antibacterial ability. Through an innovative scoring strategy, our findings showed that square micro-pillars with 6 µm width and 2 µm height combined with 85 nm diameter nanotubes was suitable for implant neck design, while square micro-pillars with 3 µm width and 3.6 µm height combined with 55 nm diameter nanotubes was the best for implant body design. Our study reveals the synergistic effect of the hierarchical micron/nano scale patterns on MG63 osteoblasts, L929 fibroblasts, SCC epithelial cells and P. gingivalis functions. It provides insight into the design of biomedical implant surfaces.

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Multi‐objective design optimization of dental implant geometrical parameters

Moradi

Aein

Youssef

2021

Numer Methods Biomed Eng

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In‐silico investigations are becoming an integral part of the development of novel biomedical devices, including dental implants. Using computer simulations can streamline the process by tuning different geometrical and structural features, emphasizing the osseointegration of the implant design a priori, leading to the optimal designs in preparation for in‐vivo trails. This research aims to elucidate the interrelationship between 12 geometrical variables that holistically define the shape of the implant. The approach to achieve optimality hinged on coupling the finite element analysis results with the fractional factorial design method. The latter was used to determine the most influential variables during the screening process, followed by the parameter optimization process using the response surface method, regarding four different objectives, namely: bone‐implant contact area, volume of trabecular bone dead cells, volume of cortical bone dead cells, and axial displacement. This resulted in reducing the number of virtual experiments and substantially decreasing the computational cost without compromising the accuracy of the solution. It was found that the optimized values improved the performance significantly. The validity of all models was verified by comparing optimized responses with simulation results. A sensitivity analysis was performed on all five optimized models to address the effect of friction coefficient on the implant‐bone joint interaction. It was shown that the mechanical behavior of implant‐bone would be independent in higher friction coefficients. The significance of this study is demonstrated in determining the most effective and optimized values of all possible geometrical parameters considering their singular or interactive effects.

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Screening the optimal hierarchical micro/nano pattern design for the neck and body surface of titanium implants

Cited by 31 publications

References 36 publications

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

Screening the Optimal Patterned Surfaces Consisting of Cell Morphology Mimicking Micro-pillars and Nanotube Arrays for the Design of Titanium Implants

Multi‐objective design optimization of dental implant geometrical parameters

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