Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Abstract

Background: Since 2019, several critical effects of the coronavirus pandemic have surfaced, including its psychological problems such as depression. The World Health Organization has approved a group of drugs and vaccines. However, the world still faces novel coronavirus mutations, requiring more ideas to investigate a drug, vaccine and phytochemical potential chemoprevention proposal. Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV)-2 co-operates directly with the Angiotensin-Converting Enzyme 2 (ACE2) to penetrate the target cells.Aims: We aim to introduce the possibility of studying seed oil extract as an anti-depression, anti-stress, anti-epinephrine receptor (PDB: 2rh1) and as potentially binding anti-angiotensinconverting enzyme 2 (ACE2) agent.

Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study

“…The results showed an improvement in the rats’ skin levels of collagenase, elastase, hyaluronidase, tyrosinase, nitric oxide (NO), malondialdehyde (MDA), and cyclooxygenase2 (COX-2) following PSOE treatment against phenobarbital and formaldehyde, with no effects in the group treated with PSOE alone. This agreed with our previous finding, where we observed no side effects on the biological profiles, including the liver and kidney profiles, DNA fragmentation, and histopathological markers at doses under 250 mL/kg following short- and long-term treatment with pomegranate seed oil extract [ 18 , 20 , 21 , 22 ]. Additionally, the results showed that the biochemical parameters in the humans were significantly ameliorated with PSOE treatment, compared with those in Group 1.…”

“…Additionally, these elements support both the immune and endocrine systems against opportunistic bacteria and fungi [ 1 , 51 , 53 ]. In both our past work and current studies, we found that pomegranate contains phytochemicals, including squalene, gamma-tocopherol, cis-11-eicosenamide, hexadecanamide, hydroxymethylfurfural, stigmastan-3,5-diene, oleamide, pentanoic acid, and octadecanoic acid, which have antiapoptotic, anti-inflammatory, antioxidant, antibacterial, and antifungal activities ( Table 2 ) [ 22 , 23 , 54 ]. Additionally, our previous findings indicated that the active phytochemicals in pomegranate could be used in schizophrenia and depression treatment, as a sedative agent, and to treat neurological stress through the downregulation of epinephrine, cortisol, and inflammatory cytokine receptors, in agreement with our current findings [ 22 , 23 , 54 ].…”

“…We crushed and extracted the pomegranate with a solvent (1: 4 w / v ) composed of hexane and ethanol (3:1). After soaking in the solvent for 20 min at room temperature (26 ± 3 °C), we separately concentrated the extracts in a 40–50 °C rotary evaporator, according to our previously reported extraction technique [ 22 ]. We obtained a total PSOE yield of 30% oil.…”

“…Moreover, pomegranate has been used to treat acute and chronic wounds, such as surgical wounds, burns, oral, stomatitis, and diabetic wounds, and gastric ulcers, producing results better than, or comparable to, those of commercial medicines, and with no adverse effects [ 19 ]. Recent studies have shown that pomegranate has antioxidant, anti-inflammatory, and antiapoptotic effects [ 18 , 20 , 21 , 22 ].…”

“…The compounds in PSOE include octadecenamide, tocopherol, oleamide, squalene, stigmas-3,5-diene, and other potential bioactive phytochemical mixtures. Most of the compounds identified in PSOE show antiapoptotic, anti-inflammatory, antioxidant, anticancer, anti-obesity, antimicrobial, and antidiabetic activities [ 22 ].…”