Identification of effective anti-HCV and anti-HIV royal jelly constituents and their acute toxicity evaluation in Albino rats

Habashy, Noha H.; Hamouda, Asmaa F.; Abu Serie, Marwa M.

doi:10.1016/j.fct.2023.114170

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…RJ can induce the production of all isotypes of antibodies, i.e., the poly-isotypic humoral immune response, indicating a better biological response [ 307 ]. In addition to RJ, purified MRJPs of Apis mellifera also showed powerful antiviral activity against HCV, HIV, and SARS-CoV-2 [ 305 , 306 , 307 , 308 , 309 , 310 , 311 ]. The antiviral effects of MRJP2 and its isoform X1 have been studied by the computational tools and 3D structure of the SARS-CoV-2 proteins (from the Protein Data Bank) which includes papain-like protease (non-structural protein nsp3), 3CL protease (nsp5), the nsp5-inhibitor complex, and RNA replicase (nsp9).…”

Section: Biological Function Of Royal Jellymentioning

confidence: 99%

Royal Jelly: Biological Action and Health Benefits

Oršolić,

Jazvinšćak Jembrek

2024

IJMS

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Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as a health-promoting food. This bee product is a mixture of important compounds, such as proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, and polyphenols, that underlie the remarkable biological and therapeutic activities of RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, the major royal jelly proteins, and specific peptides such as apisimin, royalisin, royalactin, apidaecin, defensin-1, and jelleins are characteristic ingredients of RJ. RJ shows numerous physiological and pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, and anti-tumor effects. Moreover, RJ may reduce menopause symptoms and improve the health of the reproductive system, liver, and kidneys, and promote wound healing. This article provides an overview of the molecular mechanisms underlying the beneficial effects of RJ in various diseases, aging, and aging-related complications, with special emphasis on the bioactive components of RJ and their health-promoting properties. The data presented should be an incentive for future clinical studies that hopefully will advance our knowledge about the therapeutic potential of RJ and facilitate the development of novel RJ-based therapeutic opportunities for improving human health and well-being.

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