Screening of Zingiberaceae extracts for antimicrobial and antioxidant activities

Habsah, M.; Amran, M.; Mackeen, Muhammad Mukram Mohamed; Lajis, Nordin Hj; Kikuzaki, Hiroe; Nakatani, Nobuji; Rahman, Azizah Abdul; Ghafar,; Ali, Abdul Manaf

doi:10.1016/s0378-8741(00)00223-3

Cited by 186 publications

(149 citation statements)

References 13 publications

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“…Olivaceous brown exudates appeared after 20 days of incubation at room temperature in all isolates. Zingiberaceae is the plant family which is widely distributed throughout in Southeast Asia and it presents significant resistance to both biotic and abiotic stresses (Habsah et al 2000). Z. Cassumunar is the plant in the family Zingiberaceae that is widely used in folklore remedies in many Asian countries.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Pansanit

Pripdeevech

2018

Mycology

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Forty-four endophytes were isolated from Zingiber cassumunar and identified morphologically. The ethyl acetate extracts of all endophytes were obtained. The ethyl acetate extracts were subjected to study antibacterial and antioxidant activities. The ethyl acetate extract of the Arthrinium sp. MFLUCC16-1053 showed activity against both gram-positive and gram-negative bacteria. Specifically, the minimum inhibition concentration against Staphylococcus aureus and Escherichia coli was 31.25 and 7.81 µg/mL, respectively. In addition, the crude extract showed highest antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenging at IC50 value of 28.47 µg/mL. Gas chromatography-mass spectrometry analysis revealed that the extract of the Arthrinium sp. MFLUCC16-1053 contains various antibacterial and antioxidant compounds which are β-cyclocitral, 3E-cembrene A, laurenan-2-one, sclareol, 2Z,6E-farnesol, cembrene, β-isocomene and γ-curcumene. The fungus Arthrinium sp. MFLUCC16-1053 was also identified by molecular and phylogenetic methods.

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Section: Resultsmentioning

confidence: 99%

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Pansanit

Pripdeevech

2018

Mycology

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“…This is the first research study on the effects of E. elatior on lead-induced changes in serum hepatotoxicity marker enzymes and hepatic oxidative stress markers. Habsah et al (2000) reported that crude dichloromethane and methanol extracts of E. elatior possessed antioxidant activity and antitumor promoting activity. Chan et al (2008) compared 26 different species of gingers for their antioxidative properties, and they have reported that, E. elatior ranked highest in TPC and ascorbic acid equivalent antioxidant capability (AEAC).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

et al. 2010

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-Lead is known to disrupt the biological systems by altering the molecular interactions, cell signaling, and cellular function. Exposure to even low levels of lead may have potential hazardous effects on brain, liver, kidneys and testes. The efficacy of Etlingera elatior (torch ginger) to protect hepatotoxicity induced by lead acetate was evaluated experimentally in male Sprague -Dawley rats. Rats were exposed to lead acetate in drinking water (500 ppm) for 21 days and the effects of concurrent treatment with extract of E. elatior on hepatic lipid hydroperoxides (LPO), protein carbonyl content (PCC), total antioxidants (TA), superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione STransferase (GST) levels and histopathological changes in liver were evaluated. There was a significant decrease in TA and other antioxidant enzymes (p < 0.05) and increase in LPO and PCC (p < 0.05) with lead acetate ingestion. Concurrent treatment with E. elatior extract significantly reduced the LPO and PCC (p < 0.05) in serum and increased the antioxidant enzyme levels (p < 0.05) in the liver. Significant histopathological changes were seen in hepatic tissue with chronic lead ingestion. Treatment with E. elatior significantly reduced these lead-induced changes in hepatic architecture. E. elatior has also reduced the blood lead levels (BLL). Thus, there has been extensive biochemical and structural alterations indicative of liver toxicity with exposure to lead and E. elatior treatment significantly reduced these oxidative damage. Our results suggest that E. elatior has a powerful antioxidant effect against lead-induced hepatotoxicity.

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“…The antibacterial action of the plant phenolic compounds is mediated through their reaction with the cell membrane, inactivation of essential enzymes and destruction or functional inactivation of genetic materials (Puupponen-Pimia et al, 2001;Vattem et al, 2004). The variety of vegetables have been investigated in an attempt to find natural antioxidants and to discover new chemical classes of antibacterial and anticancer agents (Essawi and Srour, 2000;Gnanamani et al, 2003;Habsah et al, 2000;Kudi et al, 1999;Nanasombat and Teckchuen, 2009).…”

Section: Introductionmentioning

confidence: 99%

High phenolics and antioxidants of some tropical vegetables related to antibacterial and anticancer activities

Daduang¹

2011

Afr. J. Pharm. Pharmacol.

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Phytochemicals play an important role in the decrease risk of free radicals associated diseases. In the present study, total phenolic contents, antioxidant, antibacterial and anticancer activities of thirty Thai vegetables have been evaluated. The results showed that phenolic contents of Thai vegetables were highly correlated with total antioxidant activities. Four vegetables in strains of Spondias pinnata Kurz., Careya sphaerica Roxb., Caesalpinia mimosoides Lamk. and Cratoxylum Subsp. Pruniflorum (Kurz.) Gogel. with high phenolic contents and total antioxidant activities, have strong antibacterial activities against Staphylococcus aureus, Salmonella typhimurium and Eschericia coli. Although, the extracted samples were non-cytotoxic as confirmed on the normal Vero cells, only C. mimosoides Lamk. extract had inhibitory effect on oral cavity cell line (IC 50 27.17 ± 5.44 µg/ml). Thus, this study suggested that some vegetables can be considered as possible therapeutic agents.

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Screening of Zingiberaceae extracts for antimicrobial and antioxidant activities

Cited by 186 publications

References 13 publications

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Antibacterial secondary metabolites from an endophytic fungus, Arthrinium sp. MFLUCC16-1053 isolated from Zingiber cassumunar

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

High phenolics and antioxidants of some tropical vegetables related to antibacterial and anticancer activities

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