Screening of Rh-Antibodies in Rh-Negative Female Infants With Rh-Positive Mothers

Hattevig, G.; Jonsson, Maria; Kjellman, Bengt; Kjellman, H; Messeter, Lisbeth; Tibblin, Elisabeth

doi:10.1111/j.1651-2227.1981.tb05737.x

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…They had a random heredity for allergy and they were followed prospectively for 12 years. This group was originally recruited to a study of Rh immunisation17but was also subject to an extensive follow up with regard to the appearance of allergic disease and IgE antibodies 18-20…”

Section: Methodsmentioning

confidence: 99%

Season of birth as predictor of atopic manifestations

Nilsson

Björkstén²,

Hattevig³

et al. 1997

Archives of Disease in Childhood

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The relation between month of birth, sensitisation, and manifestations of atopy was assessed in 209 children who were followed from birth to 12-15 years. Children born during the tree pollen season were less likely to develop allergic rhinoconjunctivitis, IgE antibodies to pollen, or a positive screening test for IgE antibodies (odds ratio 0.28, 0.41, 0.35, respectively) than children born during the rest of the year.

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Section: Methodsmentioning

confidence: 99%

Season of birth as predictor of atopic manifestations

Nilsson

Björkstén²,

Hattevig³

et al. 1997

Archives of Disease in Childhood

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“…To study properly factors influencing the increase of total IgE as well as the appearance of IgE antibodies to various antigen prospective studies are essential. We have previously analyzed Rh antibodies and dextran-reactive antibodies in a cohort of Rh-negative girls, followed from birth to 4 years of age (Hattevig et al, 1981(Hattevig et al, , 1983Bjorksten et al, 1982). In this prospective study we obtained a detailed history of feeding and allergy symptoms.…”

Section: Introductionmentioning

confidence: 99%

Clinical symptoms and IgE responses to common food proteins in atopic and healthy children

Hattevig

Kjellman

Johansson

et al. 1984

Clin Experimental Allergy

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181

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Summary The appearance of symptoms suggestive of allergy through the first 4 years of life was studied prospectively in eighty‐six healthy newborn babies. Blood samples were obtained at birth, at 3,8,25 and 48 months of age and analyzed for levels of total serum IgE and for IgE antibodies to some common foods. The occurrence of IgE antibodies was related to atopic manifestations and to a detailed history of infant feeding and family history of allergy. All infants with elevated cord blood IgE (more than 1.3 kU/1) developed manifestations of atopy. Specific IgE antibodies against egg, cow's milk and soy were demonstrated at 3, 8, 25 and 48 months in nine, twenty‐three, six and two children respectively. Egg was a more potent sensitizing agent than cow's milk, IgE antibodies to egg being present in thirty‐one samples, to cow's milk in eleven and to soy in five samples. Nine infants developed IgE antibodies to eggs or cow's milk before the introduction of these nutrients into the food. The IgE antibody levels were generally low in healthy non‐atopic children and did, with one exception, not reach RAST class 1. In contrast, the levels of IgE antibodies to egg or cow's milk were higher in eleven blood samples from atopic children. We conclude that transient low IgE antibody responses to food proteins appear relatively often even in healthy infants. High concentrations of IgE antibodies however are almost exclusively seen in infants with atopic disease. Sensitization may appear early in infancy sometimes even before the offending food has been introduced into the diet.

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“…All Rh-negative healthy female infants born from August 1977 to August 1978 to Rh-positive mothers were admitted to a previous ly reported study of Rh antibodies in healthy infants [6]. Venous blood samples were obtained at birth (cord blood), at 3.3 months (range 1.5-5.0 months) and at 8.4 months (7.5-12 months).…”

Section: Patientsmentioning

confidence: 99%

Dextran-Reactive Antibodies in Healthy Infants and Toddlers – Relation to Type of Feeding

Björkstén

Hattevig

Kjellman

et al. 1982

Int Arch Allergy Immunol

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The appearance of dextran-reactive antibodies (DRA) during the first 2 years of life was studied in 88 healthy newborn babies in an effort to provide information about the origin of DRA in normal persons. The results were related to type of feeding, immunizations and to blood group of infants and their mothers. No DRA were detected in cord sera by passive hemagglutination. At 3 months of age 42% had DRA, at 8 months 95 % and at 27 months 84%. The latter figure corresponds to previous reports of DRA in healthy adults. Peak titers were also seen at 8 months (mean 2 log titers at 3, 8 and 27 months; 2.1, 6.2 and 4.9, respectively). Breastfeeding influenced the time of appearance of DRA and the magnitude of the titers. Babies breast-fed at 3 months more often were DRA negative than those that had received cow’s milk-based formula at that time (p <0.005). However, in those breast-fed babies that were DRA positive the titers were higher than in the formula-fed infants (p <0.001). Other types of feeding e.g. juices did not influence the DRA levels. The appearance of DRA could not be explained by polyclonal stimulation of antibody production since changes of DRA titers in 11 tested patients could not be clearly related to similar changes of levels of antibodies to an unrelated hapten, trinitrophenyl. The study demonstrates that DRA appear during the first year of life, and that the appearance is influenced by exogenous factors. The most likely source of the antigen stimulation is the gastrointestinal flora which is altered by introduction of cow’s milk into the diet.

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Screening of Rh-Antibodies in Rh-Negative Female Infants With Rh-Positive Mothers

Cited by 9 publications

References 24 publications

Season of birth as predictor of atopic manifestations

Season of birth as predictor of atopic manifestations

Clinical symptoms and IgE responses to common food proteins in atopic and healthy children

Dextran-Reactive Antibodies in Healthy Infants and Toddlers – Relation to Type of Feeding

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