Season of birth as predictor of atopic manifestations

Nilsson, Lennart; Björkstén, Bengt; Hattevig, G.; Kjellman, Bengt; Sigurs, Nele; Kjellman, N.‐I. M.

doi:10.1136/adc.76.4.341

Cited by 76 publications

(70 citation statements)

References 24 publications

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“…We also found that sensitization to animal dander was more common among individuals born in January. Hwang et al [21] and Nilsson et al [22] have previously reported that the prevalence of immunoglobulin E antibodies to animal dander was higher in children born in autumn and winter. This may be, in part, explained by more frequent indoor contacts with animals during winters.…”

Section: Discussionmentioning

confidence: 97%

Analysis of inhalant allergen sensitivity by age groups in patients from Istanbul

Kepecci¹,

Kığ²

2018

biomedicalresearch

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Introduction: In this cross-sectional study, we aimed to evaluate the distribution of allergic sensitivity to the common inhalant allergens in different age groups. We also aimed to determine the factors that may be associated with sensitization in adults from the European region of Istanbul. Materials and method: Using SPSS statistical analysis software, we retrospectively evaluated Skin Prick Test (SPT) data from 2587 patients with symptoms similar to Allergic Rhinitis (AR). Results: Analysis of data revealed that that the frequency of sensitization to the common inhalant allergens significantly decreased by age. Animal dander was found to be the most common cause of allergic reactions among adult patients (p<0.05). When compared to the birth in other months, the frequency of sensitization to animal dander was significantly higher among individuals born in January (p<0.05). Gender-based analysis of the results revealed that the prevalence of sensitization to animal dander was significantly higher among females<45 y of age (p<0.05). The prevalence of sensitization to the inhalant allergens was found to be the lowest among elderly patients (42.9%; p<0.000). Conclusion: Personalized assessment of allergic conditions is important for planning a suitable treatment protocol for allergic diseases in the elderly. Our findings may contribute to design effective care plans and improve the environmental conditions for adult patients with symptoms similar to AR.

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Section: Discussionmentioning

confidence: 97%

Analysis of inhalant allergen sensitivity by age groups in patients from Istanbul

Kepecci¹,

Kığ²

2018

biomedicalresearch

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“…Hidetoshi et al (1999) reported that the OR of an asthma diagnosis increased with eotaxin quartile, with the highest quartile having an OR of 5.4 compared with the lowest eotaxin quartile, and plasma eotaxin levels were associated with asthma, independent of age, race, sex, or smoking status. Previously, Nilsson et al (1997) observed that the season of birth was a significant predictor of atopic manifestations as well as circulating IgE antibodies to mixed allergens among children aged 15 or younger. Potential explanations for the differences by birth season include seasonal differences in pregnant mothers' exposure to seasonal allergens, the baby's exposure during susceptible periods after birth, or later environmental influences during the baby's development of immunity.…”

Section: Discussionmentioning

confidence: 98%

“…Birth during late winter and spring is associated with childhood asthma (Lendor et al, 2006). The prevalence of IgE antibodies to allergens is higher among children born in the autumn and winter seasons (Nilsson et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Genetic Association between Eotaxin Genes and Asthma and Its Relationship to Birth Season in Korean Children

Ahn¹,

Bae²,

Kim³

et al. 2011

Genomics & Informatics

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Asthma is a chronic disease associated with airway constriction due to inflammation caused by eosinophils, mast cells, and T lymphocytes, leading to serious chronic illness in children. The eotaxin gene family has been shown to play an important role in the pathogenesis of asthma. We hypothesized that the distinctive variations among the four seasons in Korea may affect the expression of eotaxin polymorphisms, especially in children. We examined the possible effects of birth season (spring, March-May; summer, June-August; fall, September-November; and winter, December-February) on the phenotype of asthma in children. All SNP data sets of the eotaxin-2 and eotaxin-3 genes were collected from 78 asthma patients and 101 controls. Here, we investigated the effects of birth season on the expression of eotaxin-2 and eotaxin-3 in Korean children. Using the HAPLOTYPE procedure with the HTR method in SAS/Genetics, we showed that children born in spring and summer show significant haplotypes in both the eotaxin-2 and eotaxin-3 genes. Thus, the expression of polymorphisms in eotaxin-2 and eotaxin-3 may vary by season.

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“…The latter concept derives from a wide body of epidemiology demonstrating that exposure to relatively high levels of inhalant allergens during the first few months of life (exemplified by birth during the pollen season) is associated with markedly increased risk for expression of allergic respiratory disease in response to exposure to the same allergens in adult life (2,44), particularly in infants with positive atopic family history (45). These findings are not universally accepted, as some studies suggest that the highest risk is associated with birth 2 to 3 months before the peak of the pollen season (46), whereas others have failed to detect such relationships (47). However, it has been argued that these contrasting findings may be due to variations in the degree of fluctuation in aeroallergen levels throughout the year in different geographical areas.…”

Section: The Sensitization Window During Infancymentioning

confidence: 99%

Programming for Responsiveness to Environmental Antigens That Trigger Allergic Respiratory Disease in Adulthood Is Initiated during the Perinatal Period

Holt¹

1998

Environmental Health Perspectives

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Allergy to airborne environmental antigens (allergens) is a major cause of asthma in children and adults. This review argues that the development of allergen-specific immunologic memory of the type that predisposes to allergy development is the end result of a T-cell selection process operative during infancy, which is triggered via encounters between the immature immune system and incoming airborne allergens from the environment. In normal individuals this process leads to the development of allergen-specific T-memory cells that secure the T helper (Th)-1 pattern of cytokines, which actively suppress the growth of their allergy-inducing Th-2 cytokinesecreting counterparts. However, these protective allergen-reactive Th-1 memory cells fail to develop in some individuals, permitting the subsequent proliferation of allergen-specific Th-2 cells that can trigger allergic reactions. Recent evidence suggests that genetic predisposition to allergy may be due in part to hyperactivity of control mechanisms operative in utero and which normally protect the fetoplacental unit against the toxic effect of Th-1 cytokines.Environ Health Perspect 106(Suppl 3):795-800 (1998). http.//ehpnetl.niehs.nih.gov/docs/1998/Suppl-3/ 795-800holt/abstract. html

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Season of birth as predictor of atopic manifestations

Cited by 76 publications

References 24 publications

Analysis of inhalant allergen sensitivity by age groups in patients from Istanbul

Analysis of inhalant allergen sensitivity by age groups in patients from Istanbul

Genetic Association between Eotaxin Genes and Asthma and Its Relationship to Birth Season in Korean Children

Programming for Responsiveness to Environmental Antigens That Trigger Allergic Respiratory Disease in Adulthood Is Initiated during the Perinatal Period

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