Screening of plants acting against Heterometrus laoticus scorpion venom activity on fibroblast cell lysis

Uawonggul, Nunthawun; Chaveerach, Arunrat; Thammasirirak, Sompong; Arkaravichien, Tarinee; Chuachan, Chattong; Daduang, Sakda

doi:10.1016/j.jep.2005.08.003

Cited by 95 publications

(55 citation statements)

References 22 publications

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“…Calotropis does not act as an antidote for scorpion sting (Uawonggul et al .2006) but it was locally used in scorpion sting in study area. Acorus calamus was reported to be used as pesticide in study area and anticancer in the ayurveda but the experiment showed its insignificant inhibitory effect (Smit et al 1995).…”

Section: Discussionmentioning

confidence: 99%

“…The latex exhibits toxic irritation, inflammation and allergic reactions (Garg 1979, Tomar et al 1970 but it does not act as an antidote for scorpion stings (Uawonggul et al 2006). The flowers possess nematocidal activity (Iqbal et al 2005), analgesic (Pathak & Argal 2007) and antimycobacterial (Grange & Davey 1990) activities.…”

Section: Bombax Ceiba L Malvaceae; Bbu 105mentioning

confidence: 99%

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Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

319

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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Section: Discussionmentioning

confidence: 99%

Section: Bombax Ceiba L Malvaceae; Bbu 105mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

319

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“…Scorpion venom antidote (Uawonggul, et al, 2006), as emetic, diuretic, purgative, to treating debility, liver complaints, ringworm, leucoderma, leprosy, fever (Ghani, 1989;Mamun, et al, 2003), against nosebleed and high blood pressure (Prasad et al, 2005a).…”

Section: Aquaticamentioning

confidence: 99%

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Meira¹,

Silva²,

David³

et al. 2012

Rev. bras. farmacogn.

168

120

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Approximately 600-700 species of Ipomoea, Convolvulaceae, are found throughout tropical and subtropical regions of the world. Several of those species have been used as ornamental plants, food, medicines or in religious ritual. The present work reviews the traditional uses, chemistry and biological activities of Ipomoea species and illustrates the potential of the genus as a source of therapeutic agents. These species are used in different parts of the world for the treatment of several diseases, such as, diabetes, hypertension, dysentery, constipation, fatigue, arthritis, rheumatism, hydrocephaly, meningitis, kidney ailments and infl ammations. Some of these species showed antimicrobial, analgesic, spasmolitic, spasmogenic, hypoglycemic, hypotensive, anticoagulant, anti-infl ammatory, psychotomimetic and anticancer activities. Alkaloids, phenolics compounds and glycolipids are the most common biologically active constituents from these plant extracts.

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“…Various works have been carried out to identify the chemical constituents of the genus (Vera et al, 1993;Liu;Ruedi, 1996;Ngassoum et al, 2001;Abdel-Mogib et al, 2002;Kerntopf et al, 2002;Mendes et al, 2006), and to investigate their antioxidant (Burgi;Ruedi, 1993;Juch;Ruedi, 1997;Narukawa et al, 2001), antimicrobial (Rabe;Van Staden, 1998;Zollo et al, 1998;Mathpal et al, 2002;Rijo et al, 2002;Gaspar-Marques et al, 2006;Oliveira et al, 2007b) and pharmacological properties (Buznego;Perez-Saad, 1999;Cerqueira et al, 2004;Uawonggul et al, 2006). An extensive review of ethnobotanical uses of Plectranthus has been presented by Lukhoba et al (2006).…”

Section: Introductionmentioning

confidence: 99%

Stem and leaf anatomy of Plectranthus neochilus Schltr., Lamiaceae

Duarte¹,

Lopes²

2007

Rev. bras. farmacogn.

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RESUMO: "Anatomia caulinar e foliar de Plectranthus neochilus Schltr., Lamiaceae". Plectranthus neochilus Schltr. é uma erva aromática denominada boldo ou "boldo-gambá" e empregada no tratamento de insufi ciência hepática e dispepsia na medicina popular. Este trabalho investigou a anatomia caulinar e foliar, com a fi nalidade de contribuir na identifi cação dessa planta medicinal. O material botânico foi preparado de acordo com microtécnicas usuais. O caule tem secção transversal quadrangular e, em crescimento secundário no nível analisado, exibe epiderme unisseriada e numerosos tricomas. Os tricomas glandulares são capitados e peltados. Os primeiros têm pedicelo curto e unicelular ou longo e pluricelular e cabeça uni ou bicelular. Os peltados apresentam pedicelo curto e cabeça ovóide com oito células. Os tricomas tectores são pluricelulares, unisseriados e recobertos com cutícula granulosa. Observam-se colênquima angular, câmbio vascular formando fl oema em direção centrífuga e xilema para o centro, e calotas de fi bras perivasculares apostas ao fl oema. A lâmina foliar tem epiderme uniestratifi cada revestida por cutícula estriada, estômatos diacíticos em ambas as superfícies, numerosos tricomas similares aos do caule e mesofi lo homogêneo. A nervura central possui um ou dois feixes vasculares colaterais e o pecíolo apresenta vários feixes colaterais em arco aberto. Unitermos: Plectranthus neochilus, Lamiaceae, anatomia, boldo-gambá, tricomas.ABSTRACT: Plectranthus neochilus Schltr. is an aromatic herb named "boldo" or "boldogambá" and employed for treating hepatic insuffi ciency and dyspepsia in folk medicine. This paper has investigated its stem and leaf anatomy, in order to contribute for the medicinal plant identifi cation. The botanical material was prepared according to standard microtechniques. The stem has quadrangular transection and, in secondary growth at the level analyzed, shows uniseriate epidermis and numerous trichomes. The glandular ones are capitate and peltate. The former has short unicellular or long multicellular stalk and uni-or bicellular head. The latter presents short stalk and eight-celled ovoid head. The non-glandular trichomes are multicellular, uniseriate and coated with granular cuticle. It is observed angular collenchyma, cambia forming phloem outward and xylem inward, and perivascular fi ber caps next to the phloem. The blade has uniseriate epidermis coated with striate cuticle, diacytic stomata on both surfaces, numerous trichomes similar to the stem ones, and homogeneous mesophyll. The midrib shows one or two collateral bundles and the petiole has many of them distributed as an open arc.

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Screening of plants acting against Heterometrus laoticus scorpion venom activity on fibroblast cell lysis

Cited by 95 publications

References 22 publications

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Stem and leaf anatomy of Plectranthus neochilus Schltr., Lamiaceae

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