Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance

Weckesser, Steffi; Engel, Katharina; Simon-Haarhaus, Birgit; Wittmer, Annette; Pelz, Klaus; Schempp, Christoph M.

doi:10.1016/j.phymed.2006.12.013

Cited by 207 publications

(150 citation statements)

References 12 publications

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“…Há uma disposição mundial quanto ao uso de antimicrobianos naturais no combate a microrganismos causadores de doenças [39,40]. Neste sentindo, tanto S. aureus que pode provocar doenças, que vão desde uma simples infecção (espinhas, furúnculos e celulites) até infecções graves (pneumonia, meningite, endocardite, síndrome do choque tóxico, septicemia e outras) [41], E.coli que pode ocasionar doenças em superfícies mucosas ou ainda se disseminar através do organismo, implicando em processos de infecções gastrointestinais, urinárias e meningite [42,43], quanto outras bactérias patológicas avaliadas neste estudo, podem ser tratadas utilizando chás medicinais de S. purpurea ou associadas com antibióticos durante o tratamento, visto ser um hábito comum de muitas pessoas atualmente.…”

Section: Resultsunclassified

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Santos

Marisco

2017

Sci. Plena

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_____________________________________________________________________________O uso de plantas medicinais cada vez mais é mostrado como uma fonte alternativa para tratamento de doenças. Este trabalho visou determinar o nível genotóxico e citotóxico da infusão das folhas de Spondias purpurea L., investigar o potencial antimicrobiano e conhecer o perfil cromatográfico de compostos presentes na infusão. Foram realizados os testes Allium cepa e Artemia salina para avaliar a genotoxicidade e citotoxicidade, respectivamente. Os métodos de difusão em disco e concentração inibitória mínima (CIM) foram usados para determinar a atividade antibacteriana nas bactérias Staphylococcus epidermidis, S. aureus, Escherichia coli, Salmonella enterica sorotipo Choleraesuis, Pseudomonas aeruginosa e Klebsiella pneumoniae. No teste de A. cepa, a análise estatística não indicou diferenças significativas do índice mitótico entre os tratamentos e o controle. O teste de A. salina mostrou que a infusão apresentou toxicidade frente aos náuplios a partir da dose 10µg/mL. Em relação à atividade antibacteriana, houve presença de halos de inibição contra as bactérias S. aureus e E. coli, e quando submetidos ao CIM, a infusão apresentou atividade antibacteriana contra todas as bactérias testadas. Sendo assim, a partir desse estudo pode-se inferir que a infusão (chá) das folhas da planta S. purpurea se mostrou como uma fonte medicinal não genotóxica para o teste A. cepa, bem como uma possível fonte antitumoral indicada pelo teste A. salina, além de uma promissora fonte antibacteriana.Palavras-chaves: Genotoxicidade, Antimicrobiana, Seriguela.The use of medicinal plants is increasingly shown as an alternative source for the treatment of diseases. This study aimed to determine the level genotoxic and cytotoxic infusion of the leaves of Spondias purpurea L., study the antimicrobial potential and know the chromatographic profile of the compounds present in the infusion. Tests were performed Allium cepa and Artemia salina to assess the genotoxicity and cytotoxicity, respectively. The disk diffusion method and the minimum inhibitory concentration (MIC) they were used to determine the antibacterial activity in bacteria Staphylococcus epidermidis, S. aureus, Escherichia coli, Salmonella enterica serotype Choleraesuis, Pseudomonas aeruginosa e Klebsiella pneumoniae. On test A. cepa, statistical analysis indicated no significant differences in mitotic index between treatment and control. The test of A. salina showed that infusion toxicity has opposite from the nauplii dose 10mg / ml. With regard to antibacterial activity, there was the presence of halos of inhibition against the bacteria S. aureus e E. coli, and when subjected to MIC infusion showed antibacterial activity against all tested bacteria. Thus, from this study can be inferred that the infusions (tea) from the plant leaves S. purpurea showed as a non-genotoxic medicinal source for testing A. cepa, as well as a possible antitumor source indicated by the test A. salina, as well as a promising anti...

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Section: Resultsunclassified

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Santos

Marisco

2017

Sci. Plena

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“…For example, in a survey of 209 plants, Bishop and MacDonald (1951) reported that buckbean was one of the 10 most active species for antibacterial substances, while horsetail did not possess such properties. Specifically, buckbean extracts include aucubin, a defensive compound that can inhibit many strains of anaerobic bacteria (Weckesser et al, 2007). Marestail also contains aucubin as well as a verbascoside, another antimicrobial compound (Damtoft et al, 1994).…”

Section: Increased Organic Matter Simulationmentioning

confidence: 99%

Regulators of coastal wetland methane production and responses to simulated global change

et al. 2017

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Abstract. Wetlands are the largest natural source of methane (CH 4 ) emissions to the atmosphere, which vary along salinity and productivity gradients. Global change has the potential to reshape these gradients and therefore alter future contributions of wetlands to the global CH 4 budget. Our study examined CH 4 production along a natural salinity gradient in fully inundated coastal Alaska wetlands. In the laboratory, we incubated natural sediments to compare CH 4 production rates between non-tidal freshwater and tidal brackish wetlands, and quantified the abundances of methanogens and sulfate-reducing bacteria in these ecosystems. We also simulated seawater intrusion and enhanced organic matter availability, which we predicted would have contrasting effects on coastal wetland CH 4 production. Tidal brackish wetlands produced less CH 4 than non-tidal freshwater wetlands probably due to high sulfate availability and generally higher abundances of sulfate-reducing bacteria, whereas non-tidal freshwater wetlands had significantly greater methanogen abundances. Seawater addition experiments with freshwater sediments, however, did not reduce CH 4 production, perhaps because the 14-day incubation period was too short to elicit a shift in microbial communities. In contrast, increased organic matter enhanced CH 4 production in 75 % of the incubations, but this response depended on the macrophyte species added, with half of the species treatments having no significant effect. Our study suggests that CH 4 production in coastal wetlands, and therefore their overall contribution to the global CH 4 cycle, will be sensitive to increased organic matter availability and potentially seawater intrusion. To better predict future wetland contributions to the global CH 4 budget, future studies and modeling efforts should investigate how multiple global change mechanisms will interact to impact CH 4 dynamics.

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“…These compounds, together with other isoprenoids (sterol, isoprene, mono and diterpenes, tocopherols and carotenoids) are considered as anti-inflammatory agents ( Perez ET Al., 2007, Tawaha ET Al., 2007, Almela ET Al., 2006& Luis ET Al., 2007. Other compounds present in rosemary are the essential oils such as camphor, cineole, α-pinene, borneol which are largely used in traditional medicine, in perfumery and have also antimicrobial activity ( Marzouk ET Al., 2006, Weckessera ET Al., 2007, Gillij ET Al., 2008& Zaouali ET Al., 2008. In conclusion, we have found that extracts of R. offcinalis possesses significant hypolipidemic potential.…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

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The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(-68.57%), low density lipoprotein (LDL) (-56.34%), and triglycerides (TG) (-182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

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Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance

Cited by 207 publications

References 12 publications

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Regulators of coastal wetland methane production and responses to simulated global change

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

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