Screening of new solvents for artemisininextraction process using ab initio methodology

Lapkin, Alexei; Peters, Martina; Greiner, Lasse; Chemat, Smaïn; Leonhard, Kai; Liauw, Marcel; Leitner, Walter

doi:10.1039/b922001a

Cited by 62 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are several variants of this process, hence the times and conditions are not shown. However, the analysis presented above is quite simplistic: it has already been shown that other molecules co-extracted along with artemisinin augment its equilibrium solubility [14]. Alternative commercially used hydrocarbon solvents in this extraction are toluene and hexane/ethyl acetate (95/5 v/v) mixed solvent.…”

Section: Industrial Extraction Processesmentioning

confidence: 99%

See 1 more Smart Citation

Green Extraction of Artemisinin from Artemisia annua L

Lapkin

2015

Green Extraction of Natural Products

Self Cite

View full text Add to dashboard Cite

Section: Industrial Extraction Processesmentioning

confidence: 99%

“…A computational study of different new solvents for extraction of artemisinin highlighted high solubility of artemisinin in several carbonate solvents [14]. From the point of view of clean processing, this is a highly attractive option.…”

Section: Alternative Solvents For Extraction Of Artemisininmentioning

confidence: 99%

Green Extraction of Artemisinin from Artemisia annua L

Lapkin

2015

Green Extraction of Natural Products

Self Cite

View full text Add to dashboard Cite

“…Derived from unimolecular QC calculations, σ ‐profiles can well characterize the electrostatic polarity and charge distribution of a solvent molecule. With the main advantage of providing fundamental information at the molecular level, σ ‐profiles have been successfully applied to a variety of areas, such as the interpretation of complex molecular interactions, stereoisomer differentiation, estimation of physical properties of ionic liquids, prediction of drug similarity, and so forth. More importantly, the molecule‐specific characteristics of σ ‐profile make it possible to get not only qualitative but also quantitative information on solvent properties and behaviors.…”

Section: Solvent Theoretical Descriptors and Reaction Rate Regressionmentioning

confidence: 99%

Integrated solvent and process design exemplified for a Diels–Alder reaction

et al. 2014

View full text Add to dashboard Cite

A new kind of solvent descriptor obtained from quantum chemical calculations is introduced. Group contributions to each solvent descriptor are regressed for 71 UNIFAC groups. A reaction kinetic model is built by correlating a set of experimentally determined reaction rate constants in various solvents with the corresponding theoretical solvent descriptors. Based on the kinetic model and the developed group contribution method, a computer-aided molecular design problem is formulated and optimal solvents to achieve highest reaction rates are identified. For considering the multiple and complicated effects of solvents on a chemical process, an integrated solvent and process design is performed. Solvent molecular structures and process operations are simultaneously optimized by the formulation and solution of a mixed-integer nonlinear program. The proposed design methodology is exemplified for a selected Diels-Alder reaction.

show abstract

“…One of the most remarkable examples of the potential of synthetic biology in human health is the development of the semi-synthetic antimalarial drug artemisinin. Artemisinin, a sesquiterpene lactone endoperoxide extracted from the sweet wormwood plant (Artemisia annua) whose discovery was awarded the 2015 Nobel Prize is known to be very efficient against multidrugresistant Plasmodium spp 22 . This compound has been traditionally obtained from 8 months A. annua plants using well-described extraction methods 23 .…”

Section: Unintentional Poisonings~5mentioning

confidence: 99%

The potential of synthetic biology for improving environmental quality and human health in developing countries

Niño

Islam

2017

revsal

View full text Add to dashboard Cite

Environmental quality is a major factor in global health that mainly affects the poorest populations. Vectorborne diseases, climate change, pollution and unintentional poisonings are recognized as the primary causes of environmental diseases burden in developing countries. The development and implementation of new technologies to reduce the impact of these risk factors on health in developing countries is a priority in the current research. In this regard, synthetic biology, a nearly new research area, has initiated a big revolution through the de novo design or rewiring of biological components, organisms, and functions with the aim to reduce the adverse effects of environmental risk factors on human health. Despite synthetic biology is well recognized for being a multidisciplinary area where biotechnologist, biologist, physicists, mathematicians and engineers play together, its integration with public health and other social sciences seems to be of relevance to apply these technologies into a practical context. In this review, we discuss the major advances in synthetic biology with potential to improve environmental quality and human health in developing countries.Keywords: Public health. Synthetic biology. Developing countries. Environmental diseases. RESUMENLa calidad ambiental es reconocida como uno de los factores con mayor impacto sobre la salud humana principalmente en los países en vías de desarrollo. Las enfermedades transmitidas por vectores, el cambio climático, la contaminación y las intoxicaciones no intencionales han sido reportados como las principales causas de enfermedades ambientales en estos países. El desarrollo y la implementación de nuevas tecnologías encaminadas a reducir el impacto de estos factores ambientales en la salud es una prioridad de la investigación actual. En ese sentido, la biología sintética ha iniciado una gran revolución al permitir el diseño de novo y el mejoramiento de diversos componentes biológicos, organismos y funciones biológicas que tienen el potencial de reducir los efectos adversos de estos factores en la salud humana de una manera más eficiente y económica. A pesar de que la biología sintética es reconocida como un área multidisciplinaria donde biotecnólogos, biólogos, físicos, matemáticos e ingenieros unen sus esfuerzos, su integración con el área de la salud pública y las ciencias sociales es muy importante para llevar estas tecnologías a la práctica. En esta revisión, nosotros discutimos los más importantes avances en biología sintética y su potencial para mejorar la calidad ambiental y la salud humana en países en vías de desarrollo.

show abstract

Screening of new solvents for artemisininextraction process using ab initio methodology

Cited by 62 publications

References 32 publications

Green Extraction of Artemisinin from Artemisia annua L

Green Extraction of Artemisinin from Artemisia annua L

Integrated solvent and process design exemplified for a Diels–Alder reaction

The potential of synthetic biology for improving environmental quality and human health in developing countries

Contact Info

Product

Resources

About