Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters

Husain, Islam; Dale, Olivia R.; Martin, Katherine; Gurley, Bill J.; Adams, Sebastian John; Avula, Bharathi; Chittiboyina, Amar G.; Khan, Ikhlas A.; Khan, Shabana I.

doi:10.1016/j.jep.2022.115822

Cited by 22 publications

(27 citation statements)

References 47 publications

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“…This study’s goal was to assess the HDI potential of plants that are frequently used as components in BDS and other herbal products. The findings suggest that long-term or excessive use of herbal preparations containing these plants may increase the risk of CYP- and P-gp-mediated HDIs, which could result in unpleasant side effects from the altered pharmacokinetics of concurrently taken medications [ 93 ].…”

Section: Herb–drug Interaction Of Citrus Lmentioning

confidence: 99%

Citrus Waste as Source of Bioactive Compounds: Extraction and Utilization in Health and Food Industry

et al. 2023

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The current research was conducted to extract the bioactive compounds from citrus waste and assess their role in the development of functional foods to treat different disorders. The scientific name of citrus is Citrus L. and it belongs to the Rutaceae family. It is one of the most important fruit crops that is grown throughout the world. During processing, a large amount of waste is produced from citrus fruits in the form of peel, seeds, and pomace. Every year, the citrus processing industry creates a large amount of waste. The citrus waste is composed of highly bioactive substances and phytochemicals, including essential oils (EOs), ascorbic acid, sugars, carotenoids, flavonoids, dietary fiber, polyphenols, and a range of trace elements. These valuable compounds are used to develop functional foods, including baked products, beverages, meat products, and dairy products. Moreover, these functional foods play an important role in treating various disorders, including anti-aging, anti-mutagenic, antidiabetic, anti-carcinogenic, anti-allergenic, anti-oxidative, anti-inflammatory, neuroprotective, and cardiovascular-protective activity. EOs are complex and contain several naturally occurring bioactive compounds that are frequently used as the best substitutes in the food industry. Citrus essential oils have many uses in the packaging and food safety industries. They can also be used as an alternative preservative to extend the shelf lives of different food products.

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Section: Herb–drug Interaction Of Citrus Lmentioning

confidence: 99%

Citrus Waste as Source of Bioactive Compounds: Extraction and Utilization in Health and Food Industry

et al. 2023

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“…They reported that this interaction affected the transcription of the genes responsible for the transport of endogenous and xenobiotic elements involved in diseases management. Further, despite the previously cited beneficial biological benefits of these bioactive ingredients or compounds, some authors have revealed that they can also have health side effects and cause drug interactions due to their capacity to downregulate the transcriptional activities of Cytochrome P450 enzymes and P-glycoprotein through their antagonist effects on various others receptors such as Pregnane Xenobiotic Receptor (PXR) and Constitutive androstane receptor (CAR) [ 80 , 81 ].…”

Section: Biological Activities Of V Sinuatummentioning

confidence: 99%

Bioactive Compounds of Verbascum sinuatum L.: Health Benefits and Potential as New Ingredients for Industrial Applications

et al. 2023

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Verbascum sinuatum (V. sinuatum) is a plant belonging to the Scrophulariaceae family that has been used as an ingredient in traditional medicine infusions for the treatment of many diseases. The aerial part of this plant is a source of bioactive compounds, especially polyphenols and iridoids. Moreover, antioxidant activity studies have shown that V. sinuatum phenolic and flavonoid composition is higher than those in other plants of the same genus. V. sinuatum bioactive compound composition could vary according to the harvesting location, growing conditions of the plants, sample preparation methods, type and concentration of the extraction solvent, and the extraction methods. The obtention of these compounds can be achieved by different extraction techniques, most commonly, maceration, heat assisted extraction, and infusion. Nevertheless, since conventional extraction techniques have several drawbacks such as long times of extraction or use of large amounts of solvents, the use of green extraction techniques is suggested, without affecting the efficiency of the extraction. Moreover, V. sinuatum bioactive compounds have several biological activities, such as antioxidant, anticancer, cardiovascular, antimicrobial, antidiabetic, and neuroprotective activities, that may be increased by encapsulation. Since the bioactive compounds extracted from V. sinuatum present good potential as functional food ingredients and in the development of drugs or cosmetics, this review gives an approach of the possible incorporation of these compounds in the food and pharmacological industries.

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“…Among the interactions that may improve or impair the chemotherapeutic activity of drugs is the up-regulation of receptors such as the pregnane-X-receptor (PXR), liver-X-receptor (LXR), retinoid-X-receptor (RXR), farnesoid-X-receptor (FXR), aryl hydrocarbon receptor (AhR), or constitutive androstane receptor (CAR), some of which are reported to increase the expression of ABC transporters [ 130 , 131 , 132 , 133 ]. In addition to the up-regulation of some ABC transporters, some of these receptors can also induce the expression of enzymes responsible for drug metabolization, such as cytochrome P450 (CYP)3A4 [ 131 , 134 ]. In HepG2 cells, various plant extracts were shown to increase PXR-mediated CYP3A4 gene induction [ 135 ].…”

Section: Natural Products As Potential Candidates To Overcome Colorec...mentioning

confidence: 99%

Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier

Martins-Gomes

Silva

2023

JoX

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The role of intestinal barrier homeostasis in an individual’s general well-being has been widely addressed by the scientific community. Colorectal cancer is among the illnesses that most affect this biological barrier. While chemotherapy is the first choice to treat this type of cancer, multidrug resistance (MDR) is the major setback against the commonly used drugs, with the ATP-binding cassette transporters (ABC transporters) being the major players. The role of P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), or breast cancer resistance protein (ABCG2) in the efflux of chemotherapeutic drugs is well described in cancer cells, highlighting these proteins as interesting druggable targets to reverse MDR, decrease drug dosage, and consequently undesired toxicity. Natural products, especially phytochemicals, have a wide diversity of chemical structures, and some particular classes, such as phenolic acids, flavonoids, or pentacyclic triterpenoids, have been reported as inhibitors of P-gp, MRP1, and ABCG2, being able to sensitize cancer cells to chemotherapy drugs. Nevertheless, ABC transporters play a vital role in the cell’s defense against xenobiotics, and some phytochemicals have also been shown to induce the transporters’ activity. A balance must be obtained between xenobiotic efflux in non-tumor cells and bioaccumulation of chemotherapy drugs in cancer cells, in which ABC transporters are essential and natural products play a pivotal role that must be further analyzed. This review summarizes the knowledge concerning the nomenclature and function of ABC-transporters, emphasizing their role in the intestinal barrier cells. In addition, it also focuses on the role of natural products commonly found in food products, e.g., phytochemicals, as modulators of ABC-transporter activity and expression, which are promising nutraceutical molecules to formulate new drug combinations to overcome multidrug resistance.

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Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters

Cited by 22 publications

References 47 publications

Citrus Waste as Source of Bioactive Compounds: Extraction and Utilization in Health and Food Industry

Citrus Waste as Source of Bioactive Compounds: Extraction and Utilization in Health and Food Industry

Bioactive Compounds of Verbascum sinuatum L.: Health Benefits and Potential as New Ingredients for Industrial Applications

Natural Products as a Tool to Modulate the Activity and Expression of Multidrug Resistance Proteins of Intestinal Barrier

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