Bioactive Compounds of Verbascum sinuatum L.: Health Benefits and Potential as New Ingredients for Industrial Applications

Abstract

Verbascum sinuatum (V. sinuatum) is a plant belonging to the Scrophulariaceae family that has been used as an ingredient in traditional medicine infusions for the treatment of many diseases. The aerial part of this plant is a source of bioactive compounds, especially polyphenols and iridoids. Moreover, antioxidant activity studies have shown that V. sinuatum phenolic and flavonoid composition is higher than those in other plants of the same genus. V. sinuatum bioactive compound composition could vary according to the harvesting location, growing conditions of the plants, sample preparation methods, type and concentration of the extraction solvent, and the extraction methods. The obtention of these compounds can be achieved by different extraction techniques, most commonly, maceration, heat assisted extraction, and infusion. Nevertheless, since conventional extraction techniques have several drawbacks such as long times of extraction or use of large amounts of solvents, the use of green extraction techniques is suggested, without affecting the efficiency of the extraction. Moreover, V. sinuatum bioactive compounds have several biological activities, such as antioxidant, anticancer, cardiovascular, antimicrobial, antidiabetic, and neuroprotective activities, that may be increased by encapsulation. Since the bioactive compounds extracted from V. sinuatum present good potential as functional food ingredients and in the development of drugs or cosmetics, this review gives an approach of the possible incorporation of these compounds in the food and pharmacological industries.

The Influence of Functional Composite Coatings on the Properties of Polyester Films before and after Accelerated UV Aging

“…This confirmed that F. betulina, Verbascum L., and U. tomentosa extracts were seen to be more active against viral particles than Achillea millefolium L., Hippophae rham-noides L., and Hypericum L. extracts. Verbascum L. exhibits antiviral properties [40,41] and its alcoholic extracts have even been used in therapy, improving the health of patients with COVID-19. Additionally, F. betulina and U. tomentosa extracts were also mentioned as antiviral materials [42][43][44].…”

Elucidating the chemical profile and biological studies of Verbascum diversifolium Hochst. extracts

“…Chemically, Verbascum plants are characterized by the presence of iridoid and neolignan type glycosides, oleanan type terpenes, flavonoids, polysaccharides, saponins, steroids and alkaloids ( Küçük et al, 2016 ; Blanco-Salas et al, 2021 ; Zengin et al, 2021 ; Zengin et al, 2023 ). They possessed versatile biological properties such as antioxidant, cytotoxic, antimicrobial and anti-inflammatory activities ( Tatli and Akdemir, 2006a ; Kahraman et al, 2012 ; Blanco-Salas et al, 2021 ; Donn et al, 2023 ). Moreover, bioactives of Verbascum species, including apigenin, verbascoside and chlorogenic acid were found to possess antioxidant, anticancer, anti-Alzheimer activities ( Bender et al, 2021 ; Zengin et al, 2023 ).…”

The Antifungal and Antiviral Activity of Coatings Containing Zinc Oxide Nanoparticles and Verbascum L. or Formitopsis betulina Extracts and Their Influence on the Quality of Strawberries after Storage

“…It is important that Verbascum L. has also been found to have antiviral properties. Its aqueous and alcoholic extracts have been used in therapy, improving the prognosis of persons with COVID-19 [12,13]. Birch polypore (Fomitopsis betulina) is an edible, medicinal mushroom (when young).…”

“…As an assumption [9,10,26], it might be predicted that the introduction of ZnO nanoparticles into the F. betulina, Verbascum L. or U. tomentosa extracts (separately) might lead to antifungal and antiviral activity of the layers on the packaging material surfaces. The coatings containing zinc oxide nanoparticles as an additive will be UV resistant due to their UV-shielding properties, and they will maintain the plant extracts' active compound effectiveness [12,[16][17][18][19][20]. As a conclusion [4][5][6], to analyze the antifungal properties of the coatings' selected strains, Candida albicans PCM 2566 and Fusarium oxysporum CCM F-545 were used.…”