Screening of lactic acid bacteria strains for their ability to bind phthalate monoesters in vitro and the binding characteristics

Zhu, Yongxu; Lai, Jinghui; Liao, Xu-duo; Liu, Shuliang

doi:10.1016/j.foodcont.2018.02.013

Cited by 18 publications

(6 citation statements)

References 55 publications

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“…Studies on experimental animals have shown that phthalates and bisphenol A interfere with the endocrine system inducing developmental and reproductive toxicity [31,32]. These substances are considered to have weak estrogenic and anti-androgenic properties, mostly by competing with endogenous steroid hormones binding to receptors [33,34].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.

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Section: Introductionmentioning

confidence: 99%

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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“…Both strains were activated twice in MRS broth in preparation for BPA removal assay. Cells were obtained in accordance with the protocol described by Zhu et al (2018). First, bacterial concentration curves of strains were determined by turbidimetric method and plate count method.…”

Section: Methodsmentioning

confidence: 99%

“…Both strains were activated twice in MRS broth in preparation for BPA removal assay. Cells were obtained in accordance with the protocol described by Zhu et al (2018).…”

Section: Strains and Culture Conditionsmentioning

confidence: 99%

“…LAB strains can not only confer fermentation products with pleasant sensory characteristics, but they can also have beneficial effects on human health (Zielińska and Kolożyn‐Krajewska 2018; Chiş et al 2020). Recently, several studies have demonstrated that LAB strains can remove mycotoxins (Ge et al 2017; Ondiek et al 2021), heavy metals (Dai et al 2019; Kinoshita 2019; Li et al 2021), phthalic acid esters (Zhao et al 2017; Zhu et al 2018), polycyclic aromatic hydrocarbons (Zhao et al 2013), heterocyclic amines (Khosravi‐Darani et al 2019) and cypermethrin ( Zhang et al 2021). Two strategies have been proposed to explain how LAB strains remove contaminants, that is biosorption and biodegradation.…”

Section: Introductionmentioning

confidence: 99%

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Cell components, interaction types and functional groups involved in the in vitro binding of bisphenol A by Lactiplantibacillus plantarum RS20D and DL7X

Lai

Zhu

Liao

et al. 2022

Journal of Applied Microbiology

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Aims:The current study aimed to evaluate the capacity of two Lactiplantibacillus plantarum strains to remove Bisphenol A (BPA) and to determine the preliminary removal mechanisms underlying this process. Methods and Results:The BPA removal capacity of L. plantarum RS20D and DL7X was assessed by HPLC analysis. The effect of various treatments (physical, chemical and enzymatic) on two strains were studied to understand which interaction types worked. The different cellular components of them were also subjected to binding assays. Additionally, Fourier-transform infrared spectroscopy (FTIR) was performed to identify the functional groups related to the BPA-binding process. Results show that various treatments enhanced the binding capacity of two strains, the effect of sodium dodecyl sulphate was the most outstanding (p < 0.05). Hydrogen bonding and hydrophobic interactions likely occurred. Peptidoglycans showed the highest binding capability, protoplasts and teichoic acids might also exert a binding effect.-OH, C=O, -CH, -NH, C-N, C-O and P=O participated in BPA binding by the two L. plantarum lines.Conclusions: Peptidoglycans, protoplasts and teichoic acid played a vital role in the binding of BPA.

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“…They have beneficial effects on the host by promoting a better microbial balance within the gut and by modulating the host immune system ( 84 – 87 ). These microorganisms, specifically lactic acid bacteria (LAB), have been reported to control hypertension, modify lipid profiles and hyperglycemia, and also suppress oxidative damage ( 88 , 89 ).…”

Section: Probiotics and Their Protective Effectsmentioning

confidence: 99%

Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?

et al. 2023

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Nanoplastics (NPs) and microplastics (MPs) made of polystyrene (PS) can be toxic to humans, especially by ingestion of plastic particles. These substances are often introduced into the gastrointestinal tract, where they can cause several adverse effects, including disturbances in intestinal flora, mutagenicity, cytotoxicity, reproductive toxicity, neurotoxicity, and exacerbated oxidative stress. Although there are widespread reports of the protective effects of probiotics on the harm caused by chemical contaminants, limited information is available on how these organisms may protect against PS toxicity in either humans or animals. The protective effects of probiotics can be seen in organs, such as the gastrointestinal tract, reproductive tract, and even the brain. It has been shown that both MPs and NPs could induce microbial dysbiosis in the gut, nose and lungs, and probiotic bacteria could be considered for both prevention and treatment. Furthermore, the improvement in gut dysbiosis and intestinal leakage after probiotics consumption may reduce inflammatory biomarkers and avoid unnecessary activation of the immune system. Herein, we show probiotics may overcome the toxicity of polystyrene nanoplastics and microplastics in humans, although some studies are required before any clinical recommendations can be made.

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Screening of lactic acid bacteria strains for their ability to bind phthalate monoesters in vitro and the binding characteristics

Cited by 18 publications

References 55 publications

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Cell components, interaction types and functional groups involved in the in vitro binding of bisphenol A by Lactiplantibacillus plantarum RS20D and DL7X

Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?

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