Screening of edible plants against possible anti-tumor promoting activity

Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, ofBoesenbergia pandurata

“…The propoitions of strongly active plants (35% of the total) and of the plants being more than "weakly active" (78%) were about 4 and 3 times higher, respectively, in this study than those previously reported in the screening test of common edible plants in Japan. 6 ) And yet, the experimental conditions in this study seemed to be more stricter than those used. before, because the relative amounts of extracts to the tumor promoter were 5 times less in the present assay than in the previous test.…”

Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine

“…Koshimizu et al (1988) conducted screening tests of the methanol extracts from 121 species of Japanese vegetables and fruits for inhibitory activity toward Epstein-Barr virus early antigen (EBV-EA) activation induced by a 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue 12-Ohexadecanoylphorbol-13-acetate (HPA). As a result, 26% of the total showed significant inhibitory activity (>30% at 200 µg ml -1 ).…”

“…Curcuma domestica, Kaempferia galanga and Languas galanga from the Zingiberaceae family have been reported to demonstrate anti-tumour promoter activity (Koshimizu et al, 1988;Nishino et al, 1990). Several other ginger species are used in Malaysian traditional medicine, but their anti-tumour promoter activity has not been previously investigated.…”

“…Ursolic acid and mokko lactone, isolated from green perrilla and edible burdok extracts respectively, were found to inhibit EBV-EA activation induced by HPA (Koshimizu et al, 1988), and proven to have anti-tumourpromoting activity in ICR mice skin (Koshimizu and Ohigashi, 1991). Several other active components from common food that inhibited the TPA-induced EBV-EA activation were also shown to inhibit skin tumour formation by TPA in 7,12-dimethylbenz[a]anthracene-initiated mice .…”

Medicinal properties of Zingiber officinale Roscoe - A Review

“…Ginger has been found to be anti-carcinogenic via multiple pathways [26,7] and reported to have colon cancer chemopreventive activity. Gingerol also inhibited the growth of human colorectal cancer cells [28].…”