Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, of<i>Boesenbergia pandurata</i>

Murakami, Akira; Kondo, Akira; Nakamura, Yoshimasa; Ohigashi, Hajime; Koshimįzu, Koichi

doi:10.1271/bbb.57.1971

Cited by 53 publications

(34 citation statements)

References 3 publications

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“…Plants are used as flavors (Murakami et al 1993), natural fragrances (Guterman et al 2002), colors (Siva 2007), biopesticides (Gakuya et al 2013), pharmaceuticals (Ramachandra Rao and Ravishankar 2002), and food additives (Amakura et al 2002). Plant cell cultures have been used for more than 20 years to produce a variety of natural products (Sahai and Knuth 1985) and, more recently, to produce foreign gene products (Hiatt et al 1989;Sijmons et al 1990;James et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Effect of methyl jasmonate and salycilic acid synergism on enhancement of bilobalide and ginkgolide production by immobilized cell cultures of Ginkgo biloba

Sukito¹,

Tachibana

2016

Bioresour. Bioprocess.

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Background: Bilobalide and ginkgolides are reported to be present only in Ginkgo biloba. However, only trace amounts of bilobalide and ginkgolides are contained in the ginkgo leaves. Nowadays, there has been considerable interest in plant cell cultures as a potential alternative to traditional agriculture for the industrial production of secondary metabolites. Much effort has been put into the use of in vitro cultures as one attractive biotechnological strategy for producing bilobalide and ginkgolides of commercial interest. The aim of this study was to enhance the production of bilobalide and ginkgolides A, B, and C in cell cultures of G. biloba using immobilized cell cultures and the process of elicitation.Results: Based on the effect of the immobilization components on the free cell suspension cultures, it was considered that the jute fiber acted as an elicitor and forced the cells to release the product into the culture media. The resulting biomass was approximately 1.4 times higher than in the cell suspension cultures, and the production of bilobalide and ginkgolides A, B, and C increased 5.0, 3.3, 6.1, and 4.1 times, respectively. Eliciting with methyl jasmonate (MJ) and salicylic acid (SA) in the immobilized cells enhanced bilobalide and ginkgolides A, B, and C, compared with the unelicited controls. The highest accumulation was observed using a combination of 0.1 mM MJ + 0.1 mM SA in the immobilized cells, which produced 1.78, 1.95, 2.05, and 2.95 times more bilobalide and ginkgolides A, B, and C, respectively, than the controls. Conclusions:The positive effects of immobilized cell cultures using jute fiber and the synergism effect of SA and MJ on immobilized cells of G. biloba appear to be the optimal conditions for continuous in vitro production for commercial purposes. This is the first report on analyzing the effects of jute fiber as immobilized cell material on G. biloba cell cultures and the synergism of MJ and SA on bilobalide and ginkgolide production.

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Section: Introductionmentioning

confidence: 99%

Effect of methyl jasmonate and salycilic acid synergism on enhancement of bilobalide and ginkgolide production by immobilized cell cultures of Ginkgo biloba

Sukito¹,

Tachibana

2016

Bioresour. Bioprocess.

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“…(Zingiberaceae), known as temu kunci in Indonesia or krachai in Thailand, has been used traditionally for food and also medicinal purposes for diarrhoea, and for its antimutagenic, antitumour, anti-inflammatory activities, etc. [10][11][12]. Flavonoids such as boesenbergin A, boesenbergin B, panduratin A, cardomin, cardomonin, pinostrobin, pinocembrin, alpinetin and 5-hydroxy-7-methoxyflavanone are recognised as the bioactive components of K. pandurata [13,14].…”

Section: Introductionmentioning

confidence: 99%

Isopanduratin A from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

Hwang

Chung

Baek

et al. 2004

International Journal of Antimicrobial Agents

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“…3 Cardamonin's name comes from the fact that it can be found in cardamom spice (Fig. 4), but since the first article where it was described, 22 it has been found in many other (some of them edible) plant species, such as Alpinia blepharocalyx, 23,24 Alpinia gagnepainii, 25 Alpinia conchigera, 26,27 Alpinia hainanensis, [28][29][30][31][32][33][34][35][36][37][38][39][40] Alpinia malaccensis, 41 Alpinia mutica, 42,43 Alpinia pricei, 44 Alpinia rafflesiana, [45][46][47][48] Alpinia speciosa, 22,49,50 Amomum subulatum, 51 Artemisia absinthium, 52 Boesenbergia pandurata, [53][54][55][56][57][58][59][60] Boesenbergia rotunda, 61,62 Carya cathayensis, 63 Cedrelopsis grevei, 64 Combretum apiculatum, 65 Comptonia pere...…”

Section: Sources Of Cardamoninmentioning

confidence: 99%

“…56 EBV, is a virus from the Herpesviridae family also named as human herpes virus 4 (HHV-4), which is widely known for causing infectious mononucleosis; however, it is now recognized that it is also implicated in the promotion of several types of neoplastic processes such as Hodgkin's lymphoma. An interesting IC 50 of 3.1 lM in studies on the inhibition of EBV activation, whereas an IC 50 of 1.5 lM was obtained for acetoxychavicol acetate considered by the authors as a ''highly potent EBV activation inhibitor.''…”

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confidence: 99%

An Overview on Cardamonin

Gonçalves

Valente

Rodrigues

2014

Journal of Medicinal Food

105

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Cardamonin, as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human health. In this study, research on cardamonin is reviewed, including its natural sources, health promoting aspects, and analytical methods for its determination. Therefore, this article hopes to aid current and future researchers on the search for reliable answers concerning cardamonin's value in medicine.

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Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, ofBoesenbergia pandurata

Cited by 53 publications

References 3 publications

Effect of methyl jasmonate and salycilic acid synergism on enhancement of bilobalide and ginkgolide production by immobilized cell cultures of Ginkgo biloba

Effect of methyl jasmonate and salycilic acid synergism on enhancement of bilobalide and ginkgolide production by immobilized cell cultures of Ginkgo biloba

Isopanduratin A from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

An Overview on Cardamonin

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