Isopanduratin A from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

Hwang, Jae Kwan; Chung, Jae Youn; Baek, Nam In; Park, Jung Hee

doi:10.1016/j.ijantimicag.2003.08.011

Cited by 72 publications

(48 citation statements)

References 21 publications

(21 reference statements)

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“…In numerous studies, active natural compounds have been compared with antibacterial compounds currently employed in dentistry, such as chlorhexidine and triclosan, in order to determine their relative effectiveness (Hwang et al, 2004). Taking into account some pre-set criteria from the relevant literature, agents with MIC values of isolated phytochemicals below 20 mg/mL may be considered useful for development products for application against oral infections.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Nikolić

Glamočlija

Ferreira³

et al. 2014

Industrial Crops and Products

307

160

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Aromatic plant species of genus Thymus are important medicinal plants, highly recommended due to a range of therapeutic properties of their essential oil (thyme oil): antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. Oil is also beneficial in boosting the immune system, and helps to fight colds, flu, infectious diseases and chills. It is proved to be a urinary antiseptic, being very helpful for cystitis and urethritis. Scientific validation of traditional uses, and phytochemical and bioactivity evaluation of essential oils from Thymus serpyllum, Thymus algeriensis and Thymus vulgaris was performed. GC/MS analysis revealed thymol as major component of T. algeriensis, T. vulgaris and T.serpyllum, with a contribution of 56.02%, 48.92% and 38.50%, respectively. The three essential oils (EOs) exhibited a significant antimicrobial activity against all the tested strains, T. serpyllum oil being the most potent (MIC 2.5-5 µg/mL, MBC 5-10 µg/mL; MIC 1-2 µg/mL, MFC 2-4 µg/mL). In addition, T. serpyllum oil revealed the highest antioxidant activity in all the assays and was also the most effective one against all the tested cell lines, presenting GI 50 values of 7.02-52.69 µg/mL. Moreover, the EOs did not show any toxicity, at the tested concentrations (<400 µg/mL), for porcine liver primary cell culture. In addition to their traditional use in food and cosmetics, the great potential of the tested Thymus essential oils for application in oral disease and anticancer treatments, encourage further investigation.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Nikolić

Glamočlija

Ferreira³

et al. 2014

Industrial Crops and Products

307

160

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“…Isopanduratin A, an active compound from this plant, demonstrated antibacterial activity against many streptococci including S. mutans, S. sobrinus, S. sanguinis, and S. salivarius [11]. The MIC of isopanduratin A on Streptococcus spp.…”

Section: Discussionmentioning

confidence: 99%

“…Panduratin A from this plant possessed a very good antibacterial activity against a number of staphylococci and enterococci clinical isolates and its activity was more powerful than many commonly used antibiotics [9,10]. Isopanduratin A from this plant demonstrated antibacterial activity against Streptococcus mutans, Streptococcus sobrinus, Streptococcus sanguinis, and Streptococcus salivarius [11].…”

Section: Introductionmentioning

confidence: 96%

Bactericidal, Bacteriolytic, and Antibacterial Virulence Activities of <i>Boesenbergia pandurata</i> (Roxb) Schltr Extract against <i>Streptococcus pyogenes</i>

Limsuwan¹,

Voravuthikunchai²

2014

Trop. J. Pharm Res

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“…Boesenbergia rotunda, Boesenbergia pandurata (Robx.) Schltr), lebih dikenal dengan nama Temu Kunci, merupakan salah satu spesies dari famili Zingiberaceae yang bagian rimpangnya telah banyak digunakan sebagai obat tradisional, seperti pengobatan asma, diare, gangguan pencernaan, gatal, dan demam (Hwang et al, 2004), serta untuk pengobatan karies gigi, gangguan kolik, infeksi jamur, batuk kering, rematik dan nyeri otot. Selain itu, rimpang segar memiliki aroma yang khas dan digunakan sebagai zat penyedap masakan (Trakoontivakorn et al, 2001).…”

Section: Pendahuluanunclassified

“…Ekstrak rimpang menunjukkan efek biologis, seperti antibakteri (Hwang et al, 2004), antiinflamasi (Tuchinda et al, 2002),…”

Section: Pendahuluanunclassified

IN VITRO ANTIBACTERIAL ACTIVITY OF CHALCONE DERIVATIVES FROM Kaempferia pandurata RHIZOMES AGAINST CLINICAL ISOLATE BACTERIA

Marliyana¹,

Syah²,

Mujahidin³

2017

ALCHEMY J.Pen.Kim

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ABSTRAKTelah dilakukan uji aktivitas secara in vitro terhadap bakteri isolat klinis dari senyawa turunan calkon yang berhasil diisolasi dari rimpang temu kunci (K. pandurata). Dua senyawa turunan calkon, panduratin A (1) dan 4-hidroksipanduratin A (2) telah berhasil diisolasi dari rimpang K. pandurata. Isolasi dilakukan dengan metode ekstraksi (maserasi), kromatografi kolom vakum cair dan kromatografi radial. Identifikasi struktur dilakukan dengan metode spektroskopi NMR ( 1 H NMR, 13 C NMR, 1D dan 2D) dan dibandingkan dengan data literatur yang telah dilaporkan. Uji aktivitas antibakteri dilakukan dengan metode mikrodilusi mengacu pada CLSI, terhadap delapan bakteri isolat klinis yaitu Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysentriae dan Vibrio cholerae. Senyawa 1 dan 2 menunjukkan aktivitas antibakteri yang signifikan terhadap bakteri uji, dengan aktivitas tertinggi terhadap S.aureus dan B. subtilis dengan nilai MIC sebesar 2,4-18,8 µg/mL dan MBC pada kisaran 4,8-37,5 µg/mL. Hasi uji antibakteri menunjukkan kedua senyawa tersebut potensial sebagai senyawa antibakteri terhadap bakteri isolat klinis.Kata kunci: antibakteri, bakteri isolat klinis, 4-hidroksipanduratin A, panduratin A. ABSTRACTIn vitro antibacterial activity of chalcone derivatives from "temu kunci" (K. pandurta) rhizomes against clinical isolate bacteria has been done. Two chalcone derivatives, panduratin A (1) and 4-hydroxypanduratin A (2) were isolated from Kaempferia pandurata rhizomes. Isolation of the chemical components were done with extraction (maceration), vacuum liquid chromatography and radial chromatography methods. The structures were determined by NMR spectroscopy ( 1 H-NMR, 13C-NMR, 1D and 2D), then compare with data from literatures. Antibacterial activity was carried out with reference to the CLSI microdilution method, against eight clinical isolate bacteria such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysentriae and Vibrio

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Isopanduratin A from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans

Cited by 72 publications

References 21 publications

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Bactericidal, Bacteriolytic, and Antibacterial Virulence Activities of <i>Boesenbergia pandurata</i> (Roxb) Schltr Extract against <i>Streptococcus pyogenes</i>

IN VITRO ANTIBACTERIAL ACTIVITY OF CHALCONE DERIVATIVES FROM Kaempferia pandurata RHIZOMES AGAINST CLINICAL ISOLATE BACTERIA

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