Screening of diseases transmissible by blood in recipients prior to transfusion at a university hospital in the northeast of Brazil

Carrazzone, Cristina F. V.; Verçosa, Alinne Fernanda Amaral; Lorena, Virgínia Maria Barros de; Melo, Myllena F. A. D.; Machado, Raquel C.; Pinto, Maria B. D. A.; Brito, Ana Maria de; Gomes, Yara M.

doi:10.1590/s1516-84842006000100007

Cited by 2 publications

(4 citation statements)

References 9 publications

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“…Even though in endemic areas it may be difficult to ascertain the actual source of the infection (Carneiro‐Proietti et al , 1998; Regan et al , 2000; Carrazzone et al , 2006), it may be sufficiently safe to say that the cases detected in this study are probably due to blood transfusion and the relatively low prevalence of HTLV infection in the general population, even if higher than Europe, United States and other states in Brazil.…”

Section: Discussionmentioning

confidence: 80%

“…In Brazil, few medical services investigate blood‐borne infectious diseases in blood recipients, before the first transfusion or periodically when multiple. In the Northeast of Brazil, according to Carrazzone et al . (2006), nearly 25% of blood recipients submitted to screening for blood‐transmitted diseases prior to transfusion showed positive test results for one or more blood‐borne infectious diseases, mainly HBV.…”

Section: Discussionmentioning

confidence: 99%

“…Since 1990, several studies have reported on the occurrence of HTLV‐1/2 infection in Brazil, and blood donor screening is mandatory since 1993 (De Oliveira et al , 1990; Carrazzone et al , 2006). The median seroprevalence in Brazilian blood donors was estimated to be 0·46%, with a heterogeneous geographical distribution: lower rates in the South region, increasing towards the North and Northeast.…”

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confidence: 99%

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Lookback study of HTLV‐1 and 2 seropositive donors and their recipients in Belo Horizonte, Brazil

Namen-Lopes

Martins

Drummond

et al. 2009

Transfusion Medicine

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The objective of this study was to perform lookback study in recipients of blood components from human T-lymphotropic virus (HTLV) seropositive donors. HTLV-1/2 may be transmitted by blood transfusion. Brazil is an endemic area for the virus and its screening in blood donors is mandatory since 1993. Hemominas Foundation (HF) is the public transfusion centre in Minas Gerais, Brazil. Data on HTLV-1/2 seropositive donors and recipients from 1993 to 2004 were obtained at HF and 24 contracting hospitals. From 1993 to 2004, HTLV-1/2 enzyme immunoassay (EIA) was performed in 918 678 donations of approximately 422 600 blood donor candidates. Of these, 456 donors (0.1%) were reactive and confirmed by Western blot (WB): 449 HTLV-1 and 7 HTLV-2. Sixty-six (14.5%) were repeat donors and had 194 blood cellular components produced from their previous donations. Of the distributed components, 119/146 (81.5%) had the recipient traced, with a total of 114 individuals. Of these, only 13 recipients were tested: six (46%) were HTLV-1 positive (four recipients of red cell units, two of platelets) and seven (54%) were negative (six of red cell units and one of platelets). Eleven did not respond and 62/114 (54.0%) were deceased. Another 28/114 (25.0%) could not be located. All six seropositive HTLV-1 recipients identified had no symptoms suggestive of HTLV-1-associated diseases. Acellular components, when used alone, were not associated with HTLV seropositivity. HTLV-1 transmission by cellular blood components occurred before screening for the virus was introduced. Haemovigilance was difficult to perform due to unavailability of computer systems before 1999 and to inadequate medical records at hospitals.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Lookback study of HTLV‐1 and 2 seropositive donors and their recipients in Belo Horizonte, Brazil

Namen-Lopes

Martins

Drummond

et al. 2009

Transfusion Medicine

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“…Several studies show that the infection is more prevalent in women and occurs in clusters of higher prevalence. [15][16][17] However, recent data from a representative national study of Brazilian blood donors were lacking. We present herein the results of a collaborative study in three blood centers from different geographic regions in Brazil.…”

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confidence: 99%

Human T-Lymphotropic Virus Type 1 and Type 2 Seroprevalence, Incidence, and Residual Transfusion Risk Among Blood Donors in Brazil During 2007–2009

Carneiro-Proietti

Sabino

Leão

et al. 2012

AIDS Research and Human Retroviruses

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Human T-lymphotropic virus type 1/2 (HTLV-1/2) infection is endemic in Brazil but representative donor prevalence and incidence data are lacking. All blood donations (2007)(2008)(2009)) from three blood centers in Brazil were studied. Samples reactive on one HTLV screening test (EIA) were retested with a different EIA; dual EIA reactivity correlated strongly with a confirmatory Western blot. Prevalence, incidence, and residual transfusion risk were calculated. Among 281,760 first-time donors, 363 were positive for HTLV on both EIAs (135 per 10 5 , 95% CI 122-150). Prevalence differed considerably by region, from 83 to 222 per 10 5 . Overall incidence rate was 3.6/10 5 person-years and residual transfusion risk was 5.0/10 6 per blood unit transfused. The logistic regression model showed significant associations with: age [adjusted odds ratio (aOR) = 5.23 for age 50 + vs. < 20], female sex (aOR = 1.97), black (aOR = 2.70 vs. white), and mixed skin colors (aOR = 1.78 vs. white), and inversely with education (aOR = 0.49, college vs. less than high school). HTLV testing with a dual-EIA strategy is feasible and can be useful in areas with low resources. Incidence and residual risk of HTLV-1 transmission by transfusion were relatively high and could be reduced by improving donor recruitment and selection in high prevalence areas. Blood center data may contribute to surveillance for HTLV infection.

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Screening of diseases transmissible by blood in recipients prior to transfusion at a university hospital in the northeast of Brazil

Abstract: Screening of diseases transmissible by blood in recipients prior to transfusion at a university hospital in the Northeast of Brazil Triagem de doenças transmissíveis por sangue em receptores de um hospital universitário no Nordeste do Brasil, antes da transfusão

Cited by 2 publications

References 9 publications

Lookback study of HTLV‐1 and 2 seropositive donors and their recipients in Belo Horizonte, Brazil

Lookback study of HTLV‐1 and 2 seropositive donors and their recipients in Belo Horizonte, Brazil

Human T-Lymphotropic Virus Type 1 and Type 2 Seroprevalence, Incidence, and Residual Transfusion Risk Among Blood Donors in Brazil During 2007–2009

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