Screening of antimutagenicity via antioxidant activity in different extracts from the leaves of Acacia salicina from the center of Tunisia

Bouhlel, Inès; Mansour, Hédi Ben; Limem, Ilef; Sghaïer, Mohamed Ben; Mahmoud, Amor; Chibani, Jemni Ben; Ghedira, Kamel; Chekir‐Ghedira, Leila

doi:10.1016/j.etap.2006.07.001

Cited by 31 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These extracts exhibited an important free radical scavenging activity toward the 1,1-diphenyl-2-picrylhydrazyl (DPPH . ) free radical Bouhlel et al, 2007). These results suggested expanding our study in order to purify and test molecules obtained from the most active extract detected previously .…”

Section: Introductionmentioning

confidence: 70%

Antigenotoxic and antioxidant activities of isorhamnetin 3-O neohesperidoside fromAcacia salicina

Bouhlel

Skandrani

Nefatti

et al. 2009

Drug and Chemical Toxicology

Self Cite

View full text Add to dashboard Cite

Antioxidant activity of isorhamnetin 3-O neohesperidoside (I3ON), isolated from the leaves of Acacia salicina, was determined by the ability of this compound to inhibit lipid peroxidation and to protect against hydroxyl radical-induced DNA damage in pKS plasmid DNA and Escherichia coli cultures. Antigenotoxic activity was assessed by using the comet assay. The IC(50) value of the inhibitory activity toward lipid peroxidation by I3ON is 0.6 mM. This compound was also able to protect against hydroxyl radical-induced DNA damage in pKS plasmid DNA. Moreover, this compound induced an inhibitory activity toward H2O2-induced genotoxicity. The protective effect exhibited by this molecule was also determined by analysis of gene expression as a response to an oxidative stress, using a cDNA microarray. Transcription of several genes related to the antioxidant system (HMOX2 and TXNL) and to the DNA repair pathway (XPC, POLD1, POLD2, PCNA, DDIT3, APEX, and LIG4) were upregulated after incubation with I3ON. Taken together, these observations provide evidence that the I3ON, isolated from the leaves of A. salicina, is able to protect cells against oxidative stress.

show abstract

Section: Introductionmentioning

confidence: 70%

Antigenotoxic and antioxidant activities of isorhamnetin 3-O neohesperidoside fromAcacia salicina

Bouhlel

Skandrani

Nefatti

et al. 2009

Drug and Chemical Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The weak cytotoxic activities exhibited by some R. alaternus extracts against the two cell lines indicated that the compounds present in the extracts are non cytotoxic. However, since reactive oxygen radicals play an important role in carcinogenesis (Lee et al, 1998, Abdelwahed et al, 2007Bouhlel et al, 2007;Ben Mansour et al, 2007), it is possible to suggest that the presence of antioxidants in the active R. alaternus extracts (Chevolleau et al, 1992;Ben Ammar et al, 2005) may play some role in reducing cell number. High antibacterial and high cytotoxic activities were observed in the A 2 fraction compared to the aqueous extract A.…”

Section: Results Of These Experiments Shown Inmentioning

confidence: 99%

Antibacterial and cytotoxic activities of extracts from (Tunisian)Rhamnus alaternus (Rhamnaceae)

et al. 2007

Self Cite

View full text Add to dashboard Cite

The petroleum ether, chloroformic, ethyl acetate, methanolic, Total Oligomers Flavonoids (TOF) enriched extracts, water extract as well as its fractions A 1 , A 2 , A 3 obtained from aerial parts of Rhamnus alaternus, a Tunisian-Mediterranean medicinal species, were investigated for the contents of phenolic compounds, cytotoxic activity against the K562 human chronic myelogenous leukaemia cell line and L1210 leukaemia murine cells and for antibacterial activity against Gram positive and Gram negative bacterial reference strains. A pronounced cytotoxic effect on both the cell lines was shown in the TOF, ethyl acetate, methanolic, aqueous extracts and A 2 fraction, with respectively IC 50 values 75, 232, 298, 606 and 571 µg/ml on K562 cells and 198, 176, 767, 560 and 614 µg/ml on L1210 cell line. Significant activity against bacterial reference strains: Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Salmonella enteritidis and Salmonella typhimurium was shown with ethyl acetate, TOF extracts and A2 fraction. The antimicrobial and cytotoxic activities showed by R. alaternus depended on the chemical composition of the tested extracts.

show abstract

“…However, a comparative study of the same species, collected from two Tunisian regions (Monastir and Médenine), showed that the antioxidant activity is more extensive inside the plant samples collected from Medenine compared to those of Monastir. This result could be explained by the richness of phytosterols in Médenine plants, to which we have attributed the biological activities [25,28]. Furthermore, we have evaluated the ability of a hexane extract, prepared from fresh leaves of A. salicina on decreasing H 2 O 2 rate.…”

Section: Antioxidant Activities Of Phytosterol and Their Therapeutic mentioning

confidence: 88%

Activity of cholesterol oxidase immobilized on Layered Double Hydroxide nanomaterials for biosensor application: Acacia salicina scavenging power of hypercholesterolemia therapy

Temani¹,

Baccar²,

Mansour

2014

Microelectronic Engineering

Self Cite

View full text Add to dashboard Cite

Screening of antimutagenicity via antioxidant activity in different extracts from the leaves of Acacia salicina from the center of Tunisia

Cited by 31 publications

References 38 publications

Antigenotoxic and antioxidant activities of isorhamnetin 3-O neohesperidoside fromAcacia salicina

Antigenotoxic and antioxidant activities of isorhamnetin 3-O neohesperidoside fromAcacia salicina

Antibacterial and cytotoxic activities of extracts from (Tunisian)Rhamnus alaternus (Rhamnaceae)

Activity of cholesterol oxidase immobilized on Layered Double Hydroxide nanomaterials for biosensor application: Acacia salicina scavenging power of hypercholesterolemia therapy

Contact Info

Product

Resources

About