Screening of 5′-Methylthioadenosine Nucleosidase Enzyme Inhibitors from Traditional Chinese Medicine and Small Molecular Compounds by Capillary Electrophoresis After Enzymatic Reaction at Capillary Inlet

Yu, Kaili; Yue, Mei-E; Xu, Jie; Jiang, Tianyue

doi:10.1007/s10337-020-03873-4

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Magnetic Microreactors1

Homogeneous Online Enzyme Reaction Studies1

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2021

2022

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Cited by 4 publications

(2 citation statements)

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“…Enzymes immobilized onto magnetic material can be combined with CE in an offline mode. This was shown by Liu et al for lipase [55] and Wang et al on separate studies. The latter group grafted xanthine oxidase onto magnetic microspheregold nanoparticles [83].…”

Section: Magnetic Microreactorssupporting

confidence: 59%

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Overview of in‐capillary enzymatic reactions using capillary electrophoresis

2021

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This review summarizes the research that has recently been performed on in‐capillary enzymatic reactions integrated with capillary electrophoresis. The manuscript is subdivided in homogeneous and heterogeneous approaches. The main homogeneous techniques are Electrophoretically Mediated Microanalysis, At‐inlet and Transverse Diffusion of Laminar Flow Profiles. The main heterogeneous ones are Immobilized MicroEnzyme Reactors with enzymes grafted on either non‐magnetic or magnetic particles. The overview covers the period from 2018 to early 2021. The applications range from drug discovery over natural products to food, beverage and pesticide analysis.

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Section: Magnetic Microreactorssupporting

confidence: 59%

“…The incubation buffer differed from the BGE in terms of buffer type, buffer concentration, and pH. A group of 21 Traditional Chinese medicine (TCM) natural extracts and 8 small molecular compounds were screened for inhibitory effects [55].…”

Section: Homogeneous Online Enzyme Reaction Studiesmentioning

confidence: 99%