Potential and applications of capillary electrophoresis for analyzing traditional Chinese medicine: a critical review

Xu, Mengchang; Zhang, Hanyong; Tang, Tong Boon; Zhou, Ji; Zhou, Wenhu; Tan, Songwen; He, Binsheng

doi:10.1039/d1an00767j

“…Notably, the results of this study also showed that high NRS score was also a high risk factor for postoperative complications of bladder cancer ( P < 0.05). This indicates that the nutritional status of the body is closely related to the incidence of postoperative complications in patients with malignant tumors [ 18 , 19 ]. Further comparison of the severity of complications among patients with different NRS-2002 scores showed that the incidence of intestinal obstruction and the total incidence of complications in the NRS ≥3 group were significantly higher than those in the NRS <3 group ( P < 0.05), with no significant differences in other groups.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Nutritional Risk Assessment for Predicting Complications after Radical Cystectomy plus Urinary Diversion for Bladder Cancer

Wang

¹

,

Wang²,

Liu

³

et al. 2022

Emergency Medicine International

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Objective. To investigate the predictive value of preoperative nutritional risk assessment on the occurrence of complications after radical cystectomy plus urinary diversion for bladder cancer. Methods. Retrospective analysis of 178 patients with bladder cancer between July 2010 and March 2022 who underwent elective radical cystectomy plus urinary diversion was conducted. The occurrence of complications within 90 days after surgery was counted for all patients, and the postoperative complication rates of patients with and without nutritional risk were compared and analyzed. Also, logistic regression analysis was used to assess the relative risk coefficients of NRS-2002 and the occurrence of postoperative complications. Results. Comparison of clinicopathological characteristics and surgical conditions between the two groups showed that the proportion of combined diabetes mellitus, operative time, and postoperative hospital stay were higher in the nutritional risk group (NRS ≥3 score) than in the no nutritional risk group (NRS <3 score), while the preoperative blood albumin (ALB) level was lower than that in the no nutritional risk group (NRS <3 score). The results of multifactorial risk regression analysis showed that low preoperative ALB level and high NRS score were independent risk factors for postoperative complications in bladder cancer ( P < 0.05 ). Conclusion. The NRS-2002 nutritional risk score has good predictive value for the incidence of postoperative complications in patients with bladder cancer and provides a scientific basis for perioperative nutritional support.

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“…Fast-track intravenous anesthesia combined with spinal-epidural anesthesia or nerve block anesthesia is commonly used in clinical anesthesia. Spinal-epidural anesthesia can theoretically be used for all surgical anesthetics except those below the head and for postoperative analgesia, but its safety is unsatisfactory [ 12 ]. The results of this study showed that there was no statistical difference between the two groups in the one-time success rate of the operation, and all patients were successful at one time.…”

Section: Discussionmentioning

confidence: 99%

Safety of Different Anesthesia Methods Combined with Intravenous Fast Channel Anesthesia in Lower Extremity Orthopedic Surgery of the Elderly

Chen

¹

,

Yang

²

,

Hu

³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To compare the safety of different anesthesia methods combined with intravenous fast channel anesthesia in elderly lower extremity surgery and the effect on postoperative outcome. Methods. A total of 106 elderly patients who underwent lower extremity orthopedic surgery in our hospital from February 2018 to February 2021 were selected and randomly divided into the control group (n = 53) and the observation group (n = 53) according to random number table. All patients received intravenous fast-track anesthesia. On this basis, the control group received spinal-epidural anesthesia, and the observation group received iliac fascial space block on the affected side combined with sciatic nerve block. The operation conditions, blood pressure and heart rate changes, awakening time, postoperative ICU admission rate, and complications were compared between the two groups. Results. There was no statistical difference in the success rate of one-time operation between the two groups ( P > 0.05 ). The times of using analgesics and vasoactive drugs and the dosage of propofol in the observation group during the operation were lower than those in the control group, and the difference was statistically significant ( P < 0.05 ). At T2, T3, and T4, the levels of HR, DBP, and SBP in the observation group were lower than those in the control group, and the difference was statistically significant ( P < 0.05 ). After operation, the time of awakening, spontaneous breathing recovery, and extubation in the observation group were lower than those in the control group, and the difference were statistically significant ( P < 0.05 ). The incidence of complications in the observation group was lower than that in the control group, the cognitive impairment was the most significant one in the incidence of single complication, and the difference was statistically significant ( P < 0.05 ). Conclusion. Based on the combined intravenous fast channel anesthesia, the operation difficulty of the affected side iliac fascial space block combined with sciatic nerve block is the same as that of spinal-epidural anesthesia. It has a higher success rate of one operation, better analgesic and anesthetic effects during the operation, and little effect on blood flow of patients. It can maintain relatively stable heart rate and blood pressure and does not easily cause postoperative complications. Its safety is higher than that of spinal-epidural anesthesia.

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“…Acyclovir and ganciclovir both showed good effects on abnormally high proportion of abnormal lymphocytes, proportion of lymphocytes, and white blood cell count, but ganciclovir showed better effects. Ganciclovir has a broader antiviral spectrum than acyclovir, and the DNA polymerase of the EBV is highly sensitive to both triphosphates of acyclovir and ganciclovir [ 13 , 14 ]. Ganciclovir is converted into activated triphosphate by thymidine kinase action in infected cells, which competitively inhibits viral DNA polymerase, terminates EBV-DNA prolongation, and inhibits replication of its viral products.…”

Section: Discussionmentioning

confidence: 99%

Difference between Acyclovir and Ganciclovir in the Treatment of Children with Epstein–Barr Virus-Associated Infectious Mononucleosis

Zhang

¹

,

Zhu

²

,

Jin

³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the efficacy differences between acyclovir and ganciclovir in the treatment of children with Epstein–Barr virus (EBV)- associated infectious mononucleosis (IM). Methods. A total of 128 children with EBV-IM who were admitted to our hospital from February 2019 to February 2021 were selected and randomly divided into the acyclovir group (n = 64) and the ganciclovir group (n = 64) according to the random number table method. All the children were given symptomatic treatments such as protecting the liver and reducing fever. On this basis, the acyclovir group was given an intravenous drip of acyclovir, while the ganciclovir group was given an intravenous drip of ganciclovir. The treatment was continued for 7 days. After the treatment, the clinical efficacy, disappearance time of symptoms and signs, related blood routine indexes, EBV-DNA negative conversion rate, and the incidence of adverse reactions during the treatment were compared between the two groups. Results. After treatment, the total effective rate of the ganciclovir group (92.19%) was higher than that of the acyclovir group (73.44%) and the difference was statistically significant P < 0.05 . The disappearance time for the symptoms and signs of angina, fever, lymphadenopathy, hepatomegaly, and splenomegaly in the ganciclovir group was lower than that in the acyclovir group, and the difference was statistically significant P < 0.05 . After treatment, the levels of atypical lymphocyte proportion, lymphocyte proportion, and WBC count in the two groups were lower than those before treatment, the levels in the ganciclovir group were lower than those in the acyclovir group, and the difference was statistically significant P < 0.05 . After treatment, the EBV-DNA negative conversion rate (81.25%) in the ganciclovir group was higher than that in the acyclovir group (60.93%) and the difference was statistically significant P < 0.05 . During treatment, the incidence of adverse reactions in the ganciclovir group was significantly lower than that in the acyclovir group and the difference was statistically significant P < 0.05 . Conclusion. In the treatment of children with EBV-IM, the therapeutic effect of ganciclovir is obviously superior to that of acyclovir. Ganciclovir can quickly eliminate the symptoms of angina, fever, enlarged lymph nodes, and other signs in children, can improve abnormal blood indicators, and has a higher negative conversion rate of EBV and less adverse reactions.

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Potential and applications of capillary electrophoresis for analyzing traditional Chinese medicine: a critical review

Abstract: Capillary electrophoresis (CE) presents a promising prospect in analyzing traditional Chinese medicine (TCM) due to its low reagent consumption, high analysis speed, and enhanced efficiency. Herein, we review the employment...

Cited by 19 publications

References 121 publications

Preoperative Nutritional Risk Assessment for Predicting Complications after Radical Cystectomy plus Urinary Diversion for Bladder Cancer

Preoperative Nutritional Risk Assessment for Predicting Complications after Radical Cystectomy plus Urinary Diversion for Bladder Cancer

Safety of Different Anesthesia Methods Combined with Intravenous Fast Channel Anesthesia in Lower Extremity Orthopedic Surgery of the Elderly

Difference between Acyclovir and Ganciclovir in the Treatment of Children with Epstein–Barr Virus-Associated Infectious Mononucleosis

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