Screening Mammography for Women Younger Than 50 Years—Reply

Alper, Philip R.

doi:10.1001/jama.282.13.1226

Cited by 5 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies of medical screening and choice have produced mixed economic results (O'Connor et al, 2003). And increased consumer demand for costly name-brand pharmaceuticals generated by direct-to-consumer advertising has clearly increased costs and put an economic strain on managed care plans (Alper, 1999).…”

Section: Does Shared Decision-making Improve Outcomes?mentioning

confidence: 99%

Shared Decision-Making and Evidence-Based Practice

Adams

Drake

2006

Community Ment Health J

250

209

View full text Add to dashboard Cite

Shared decision-making refers to a process of health care delivery in which practitioners and clients seeking help for problems or disorders collaborate to access relevant information and to enable client-centered selection of health care resources. Though nearly all clients express a desire for more information, preferences for participation in health care decisions vary by individual and by illness. Two common strategies to promote shared decision-making are communication training for clients and clinicians, and decision aids to provide targeted information and values clarification. Research in several areas of medicine shows that active client participation results in a variety of benefits, from increased satisfaction to decreased symptom burden. Many current mental health interventions promote client-centered care, client choice, and self-directed care, but research on shared decision-making in mental health for clients with severe and persistent mental illness is just beginning.

show abstract

Section: Does Shared Decision-making Improve Outcomes?mentioning

confidence: 99%

Shared Decision-Making and Evidence-Based Practice

Adams

Drake

2006

Community Ment Health J

250

209

View full text Add to dashboard Cite

show abstract

“…3 Editorials and letters [4][5][6][7] indicate that physicians are not always pleased with these marketing practices. 3 Editorials and letters [4][5][6][7] indicate that physicians are not always pleased with these marketing practices.…”

mentioning

confidence: 99%

Student Understanding of the Relationship Between the Health Professions and the Pharmaceutical Industry

Monaghan

Galt²,

Turner

et al. 2003

Teaching and Learning in Medicine

View full text Add to dashboard Cite

show abstract

GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells

et al. 2011

View full text Add to dashboard Cite

BackgroundGrowth-differentiation factor-15 (GDF-15) is a stress-responsive, transforming growth factor-β-related cytokine, which has recently been reported to be elevated in serum of patients with idiopathic pulmonary arterial hypertension (IPAH). The aim of the study was to examine the expression and biological roles of GDF-15 in the lung of patients with pulmonary arterial hypertension (PAH).MethodsGDF-15 expression in normal lungs and lung specimens of PAH patients were studied by real-time RT-PCR and immunohistochemistry. Using laser-assisted micro-dissection, GDF-15 expression was further analyzed within vascular compartments of PAH lungs. To elucidate the role of GDF-15 on endothelial cells, human pulmonary microvascular endothelial cells (HPMEC) were exposed to hypoxia and laminar shear stress. The effects of GDF-15 on the proliferation and cell death of HPMEC were studied using recombinant GDF-15 protein.ResultsGDF-15 expression was found to be increased in lung specimens from PAH patients, com-pared to normal lungs. GDF-15 was abundantly expressed in pulmonary vascular endothelial cells with a strong signal in the core of plexiform lesions. HPMEC responded with marked upregulation of GDF-15 to hypoxia and laminar shear stress. Apoptotic cell death of HPMEC was diminished, whereas HPMEC proliferation was either increased or decreased depending of the concentration of recombinant GDF-15 protein.ConclusionsGDF-15 expression is increased in PAH lungs and appears predominantly located in vascular endothelial cells. The expression pattern as well as the observed effects on proliferation and apoptosis of pulmonary endothelial cells suggest a role of GDF-15 in the homeostasis of endothelial cells in PAH patients.

show abstract

Screening Mammography for Women Younger Than 50 Years—Reply

Cited by 5 publications

References 5 publications

Shared Decision-Making and Evidence-Based Practice

Shared Decision-Making and Evidence-Based Practice

Student Understanding of the Relationship Between the Health Professions and the Pharmaceutical Industry

GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells

Contact Info

Product

Resources

About