Screening for unilateral intracranial abnormalities using near infrared spectroscopy. A preliminary report

Francis, Sheeja V.; Ravindran, G.; Visvanathan, K; Ganapathy, K

doi:10.1016/j.jocn.2004.06.009

Cited by 17 publications

(18 citation statements)

References 15 publications

(12 reference statements)

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“…28 The profound effect that the presence of hematomas or intracranial mass lesions can have on the cerebral NIRS parameters yielded within the context of TBI has led to this modality being examined as a screening tool for the presence of these lesions since the early 1990s. [29][30][31][32][33][34] Primarily, these investigations examined the mean difference in optical density between each cerebral hemisphere (DOD) as a means of localizing pathology or predicting the presence of a localized hematoma or mass lesion. Within this area of study, work conducted by Robertson and coworkers 31 examined parameters retrieved from > 300 patients under observation after sustaining a TBI.…”

Section: Davies Et Almentioning

confidence: 99%

“…Unfortunately, as with many other monitoring modalities within the field of brain injury medicine, there is very limited evidence to support the ability of NIRS to predict outcome after injury. Although frequently referred to in limited clinical investigations, [17][18][19][29][30][31][32][33][34][35][36][37] no substantial prospective investigation provides useful information regarding how NIRS parameters can be used to predict the eventual impact of a particular injury. This in particular provides an opportunity for very meaningful investigations to be undertaken in the future.…”

Section: Davies Et Almentioning

confidence: 99%

See 1 more Smart Citation

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

Davies

Clancy

et al. 2015

Journal of Neurotrauma

123

101

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Cerebral near-infrared spectroscopy (NIRS) has long represented an exciting prospect for the noninvasive monitoring of cerebral tissue oxygenation and perfusion in the context of traumatic brain injury (TBI), although uncertainty still exists regarding the reliability of this technology specifically within this field. We have undertaken a review of the existing literature relating to the application of NIRS within TBI. We discuss current ''state-of-the-art'' NIRS monitoring, provide a brief background of the technology, and discuss the evidence regarding the ability of NIRS to substitute for established invasive monitoring in TBI.

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Section: Davies Et Almentioning

confidence: 99%

Section: Davies Et Almentioning

confidence: 99%

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

Davies

Clancy

et al. 2015

Journal of Neurotrauma

123

101

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“…In adults, NIRS technology can diagnose ICH on presentation, as well as late hematomas that develop (Francis et al, 2005;Gopinath et al, 1993Gopinath et al, ,1995Kahraman et al, 2006;Robertson et al, 1995Robertson et al, ,1997Zang et al, 2000). Although the type of hematoma (subdural [SDH] versus epidural [EDH]) cannot be determined, the presence of any hematoma would be useful to triage a patient for CT scanning.…”

Section: Introductionmentioning

confidence: 99%

“…The prior adult data (Francis et al, 2005;Gopinath et al, 1993Gopinath et al, ,1995Kahraman et al, 2006;Robertson et al, 1995Robertson et al, ,1997Zang et al, 2000) suggest that this goal is feasible with NIRS. In initial studies, the sensitivity for identification of traumatic extracerebral (EDH and SDH), and intracerebral hematomas, was 100% and 98%, respectively (Gopinath et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

The Utility of Near Infrared Spectroscopy in Detecting Intracranial Hemorrhage in Children

Salonia

Bell

Kochanek

et al. 2012

Journal of Neurotrauma

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A prospective case-control study was conducted in a tertiary care pediatric intensive care unit (PICU) to evaluate the use of near infrared spectroscopy (NIRS) for the detection of intracranial hemorrhage (ICH) in children. Subjects 0-14 years of age who had a computed tomography (CT) scan of the head performed as part of clinical care were eligible for enrollment. The children were stratified into two groups based on whether the CT was normal or abnormal. Children in the abnormal imaging cohort were further divided into those with ICH and those with other abnormalities of the brain parenchyma (contusions, diffuse axonal injury [DAI], or cerebral edema) or fractures. NIRS measurements were performed on all subjects within 24 h of head CT. The NIRS operator was blinded to the presence or absence of ICH. NIRS measurements were performed in eight different scalp locations (four bilaterally). A total of 103 measurements were made. The optical density (OD) was automatically calculated by comparing the reflected and diffused optical signal. A ΔOD>0.2 between hemispheres in any scalp location was considered abnormal. NIRS was performed in a total of 28 subjects: 7 had normal imaging and 21 had abnormal imaging. Of those with abnormal imaging, 12 had ICH. The sensitivity and specificity of NIRS at detecting ICH was 1.0 and 0.8, respectively. The positive and negative predictive values were 0.8 and 1.0, respectively. In conclusion, NIRS correctly identified all cases of ICH in this pilot study. Our preliminary results suggest that NIRS may be beneficial in the evaluation of a child with possible ICH.

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“…To enable early identification of intracranial hematomas in the field and emergency centers, a portable near-infrared (NIR) technology-based device has been used and proved high sensitivity and specificity in clinical trials for detecting hematomas larger than 3.5 mL and located within 2.5 cm depth [5][6][7][8] . More devices based on NIRS with different parameters (e.g., wavelengths, source-detector separations) are being developed for hematoma detection as well [9,10] .…”

Section: Introductionmentioning

confidence: 99%

Elucidation of the role of biological factors and device design in cerebral NIRS using an in vivo hematoma model based on high-intensity focused ultrasound

Wang

Huang

Myers

et al. 2016

Clinical and Translational Neurophotonics; Neural Imaging and Sensing; And Optogenetics and Optical Manipulation

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Near-Infrared Spectroscopy (NIRS) is an emerging medical countermeasure for rapid, field detection of hematomas caused by traumatic brain injury (TBI). Bench and animal tests to determine NIRS sensitivity and specificity are needed. However, current animal models involving non-invasively induced, localized neural damage are limited. We investigated an in vivo murine hematoma model in which cerebral hemorrhage was induced noninvasively by highintensity focused ultrasound (HIFU) with calibrated positioning and parameters. To characterize the morphology of induced hematomas, we used skull-intact histological evaluation. A multi-wavelength fiberoptic NIRS system with three source-detector separation distances was used to detect hematoma A 1.1 MHz transducer produced consistent small-tomedium hematoma localized to a single hemisphere, along with bruising of the scalp, with a low mortality rate. A 220 kHz transducer produced larger, more diffuse hematomas, with higher variability in size and a correspondingly higher mortality rate. No skin bruising or blood accumulation between the skin and skull was observed following injury application with the 220 kHz transducer. Histological analysis showed higher sensitivity for larger hematomas (>4x4 mm 2 ). NIRS optical density change after HIFU was able to detect all hematomas, with sensitivity dependent on wavelength and separation distance. While improvements in methods for validating cerebral blood distribution are needed, the HIFU hematoma model provided useful insights that will inform development of biologically relevant, performance test methods for cerebral NIRS systems.

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Screening for unilateral intracranial abnormalities using near infrared spectroscopy. A preliminary report

Cited by 17 publications

References 15 publications

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

The Utility of Near Infrared Spectroscopy in Detecting Intracranial Hemorrhage in Children

Elucidation of the role of biological factors and device design in cerebral NIRS using an in vivo hematoma model based on high-intensity focused ultrasound

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