Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia

Ramadhan, Rico; Kristanti, Alfinda Novi; Amirta, Rudianto; Kusuma, Irawan Wijaya; Phuwapraisirisan, Preecha; Haqiqi, Muhammad Taufiq; Saparwadi, Saparwadi

doi:10.13057/biodiv/d200705

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…The extraction of ten ethnomedicinal plants from East Kalimantan was performed according to the methods of Ramadhan et al (2019). In order to prepare crude methanol extract, a dried powder sample from ten ethnomedicinal plants was treated three times with methanol at room temperature for two days.…”

Section: Extraction Of Ethnomedicinal Plantsmentioning

confidence: 99%

“…In vitro rat α-glucosidase inhibition was assessed based on the previously described method by Ramadhan et al (2019) with minor modifications. The subsequent enzyme reactions were carried out in a buffer phosphate system, then all extracts were equipped and individually dissolved in DMSO (Dimethyl sulfoxide) with various final concentrations (0.0025-0.0625 mg/mL).…”

Section: Antidiabetic Activity Rat α-Glucosidase Inhibitory Activitymentioning

confidence: 99%

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The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

et al. 2022

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Abstract. Ramadhan R, Phuwapraisirisan P, Amirta R, Darmawan MFB, Ul-Haq K, Kusuma IW, Suwito H, Abdulgani N, Mukhdlor A, Saparwadi. 2022. The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers. Biodiversitas 23: 2225-2231. Ten ethnomedicinal plant extracts from East Kalimantan flora, traditionally used to treat blood sugar levels and other diabetes-related diseases, were examined in vitro for their antidiabetic and free radical scavenging activities by inhibiting rat alpha-glucosidase and several free radicals such as DPPH, ABTS, and Nitric oxide respectively. Out of the ten plant species investigated for their antidiabetic activity against maltase and sucrase rat alpha-glucosidase, three exhibited the strongest ?-glucosidaseinhibitory activity with maltose as a substrate, namely extracts of Garcinia nervosa, Syzygium caudatilimbum, and Shorea balangeran with IC50 values of 0.046; 0.037; 0.045 mg/mL. Meanwhile, quercetin as a positive control appeared to have a comparable IC50value. Furthermore, among the ten extracts, Syzygium caudatilimbum, Shorea balangeran, and Ixora javanica showed good inhibition against sucrase rat alpha-glucosidase. Moreover, the antioxidant test showed that the ten methanol extracts of plants from East Kalimantan have an antioxidant activity indicated by IC50values. The present study confirms that the ethnopharmacological use of selected plants from East Kalimantan might have potential as an antidiabetic and natural antioxidant.

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Section: Extraction Of Ethnomedicinal Plantsmentioning

confidence: 99%

Section: Antidiabetic Activity Rat α-Glucosidase Inhibitory Activitymentioning

confidence: 99%

The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

et al. 2022

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“…There has been no report of P. galeata as an antioxidant. However, a plant from the same genus, P. azurea exhibited radical scavenging activity against DPPH, ABTS, and nitric oxide (NO) (33).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Acetylcholinesterase Inhibitor Potentials of the Stem Extract of Pternandra galeata

Suciati

Inayah

Widyawaruyanti

et al. 2022

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Background: Pternandra galeata belongs to the family Melastomataceae. It is a native flowering plant in Borneo Island that serve as food for monkey habitat. There has been limited study on the medicinal and chemical properties of this plant. Objectives: We investigated the acetylcholinesterase inhibitory activity and evaluated the antioxidant activity of the ethanolic extract of Pternandra galeata stem. The total phenolic content in the sample was also determined. Methods: The acetylcholinesterase inhibitory assays were performed using Ellman’s method. Two different methods were used to evaluate the antioxidant activity of 2,2-diphenyl-1-picryl hydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The total phenolic content was determined by the Folin-Ciocalteu method by employing gallic acid as a reference. Results: The ethanolic extract of the P. galeata stems inhibited the AChE enzyme with an IC50value of 74.62 ± 0.89 µg/mL. The sample exhibited antioxidant activity in the DPPH assay with an IC50 value of 20.21 ± 0.08 µg/mL and 7.68 ± 0.09µg/mL in the ABTS scavenging assay. The total phenolic content was 164.71 ± 3.33 mg GAE/g extract. Conclusion: The ethanolic extract of the P. galeata stem can be a promising cholinesterase inhibitor and antioxidant for treating Alzheimer’s disease.

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“…The samples were divided into two groups; 15 subjects with EMNG results that did not support the diabetic neuropathy referred to as control group and 15 subjects with EMNG results that supported the diabetic neuropathy, hereinafter referred to as case/experimental group. The sampling conducted for 5 (five) months 7 .…”

Section: Methodsmentioning

confidence: 99%

Correlation between High Serum Uric Acid Levels with Occurrence of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes

2020

IJFMT

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Background: Diabetic Peripheral Neuropathy is a chronic microvascular complication of type 2 diabetes mellitus (T2DM) leads to increased risk of foot ulceration and morbidity.The increased serum uric acid (SUA) levels have been linked to macro vascular disease in T2DM. We found that the correlation between SUA levels and diabetic peripheral neuropathy has not been investigated.Objective: To determine the correlation between high serum uric acid levels and diabetic peripheral neuropathy. Method:The case-control design was used in this study and the sampling was done consecutively by following the inclusion and the exclusion criteria. The diabetic peripheral neuropathy was evaluated using EMNG and the serum were taken for uric acid levels examination. Chi square test was used for data analysis.Results: Thirty subjects were enrolled and divided into an experimental group of 15 subjects and a control group of 15 subjects as well. We found that the diabetic peripheral neuropathy did not show a significant correlation with high serum uric acid levels, p=0,136 and OR 3,143 (CI 95% 0,681-14,503). Conclusion:High serum uric acid levels did not have correlation with diabetic peripheral neuropathy.

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Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia

Cited by 7 publications

References 32 publications

The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

Antioxidant and Acetylcholinesterase Inhibitor Potentials of the Stem Extract of Pternandra galeata

Correlation between High Serum Uric Acid Levels with Occurrence of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes

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